The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia

Xueya CHEN; Jinmei XU; Zhi LI; Yan LIANG; Yufeng YAO; Fengquan HE; Zhiling YAN

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 >

Xueya CHEN, Jinmei XU, Zhi LI, Yan LIANG, Yufeng YAO, Fengquan HE, Zhiling YAN. The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia[J]. Journal of Kunming Medical University.

Citation:

PDF( 611 KB)

The Association of HOXD-AS2 and MIR3142HG Gene Polymorphisms with Cervical Intraepithelial Neoplasia

Xueya CHEN¹,
Jinmei XU²,
Zhi LI³,
Yan LIANG⁴,
Yufeng YAO¹,
Fengquan HE^{5
,
,},
Zhiling YAN^{2, 3
,
,}

1.
Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118
2.
Dept. of Gynaecologic Oncology，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118
3.
Dept. of Gynecology，The 1st People’s Hospital of Yuanmou County，Yuanmou Yunnan 651300
4.
College of Nursing Health Sciences，Yunnan Open University，Kunming Yunnan 650500
5.
Dept. of Gynaecology and Obstetrics Maternal，Maternal and Child Health Hospital of Honghe Prefecture，Honghe Yunnan 661199，China

Received Date: 2024-06-27
Available Online: 2024-11-06

Abstract

Abstract

Objective To explore the association of HOXD-AS2 and MIR3142HG gene polymorphism with cervical intraepithelial neoplasia （CIN）. Methods Two single nucleotide polymorphisms （SNPs） located in HOXD-AS2 （rs1348808） and located in MIR3142HG （rs2431099） were selected using bioinformatics tools. The two candidate SNPs were genotyped in 976 healthy individuals and 419 patients with CIN using the TaqMan probe method for genotyping, and the association with CIN were analyzed. Results rs1348808 C allele might be the protective factor for CIN3 as well as the progression from CIN2 to CIN3 （OR = 0.77, 95%CI: 0.63～0.94; OR = 0.57, 95%CI: 0.37～0.90）. Similarly, rs2431099 A allele might be the protective factor of CIN2 （OR = 0.50, 95%CI: 0.31～0.80）. Conclusion HOXD-AS2 and MIR3142HG gene polymorphisms might be associated with CIN.
- Cervical intraepithelial neoplasia,
- lncRNA,
- SNP,
- MAPK signaling pathway

FullText(HTML)

References(23)

References

[1]	Arbyn M,Ronco G,Anttila A,et al. Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer[J]. Vaccine,2012,30(Suppl 5):F88-F99.
[2]	赵超,毕蕙,赵昀,等. 子宫颈高级别上皮内病变管理的中国专家共识[J]. 中国妇产科临床杂志,2022,23(2):220-224.
[3]	Mccredie M R,Sharples K J,Paul C,et al. Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: A retrospective cohort study[J]. Lancet Oncol,2008,9(5):425-434. doi: 10.1016/S1470-2045(08)70103-7
[4]	Zheng R,Zhang S,Zeng H,et al. Cancer incidence and mortality in China,2016[J]. Journal of the National Cancer Center,2022,2(1):1-9. doi: 10.1016/j.jncc.2022.02.002
[5]	Kawase K,Taguchi A,Ishizaka A,et al. Allelic loss of HLA class I facilitates evasion from immune surveillance in cervical intraepithelial neoplasia[J]. HLA,2024,103(6):e15509. doi: 10.1111/tan.15509
[6]	Hangauer M J,Vaughn I W,Mcmanus M T. Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs[J]. PLoS Genet,2013,9(6):e1003569. doi: 10.1371/journal.pgen.1003569
[7]	Kaewsapsak P,Shechner D M,Mallard W,et al. Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking[J]. Elife,2017,6(1):e29224.
[8]	Melé M,RInn J L. "Cat's cradling" the 3D genome by the act of lncRNA transcription[J]. Mol Cell,2016,62(5):657-664. doi: 10.1016/j.molcel.2016.05.011
[9]	Lee S,Kopp F,Chang T C,et al. Noncoding RNA NORAD regulates genomic stability by sequestering PUMILIO proteins[J]. Cell,2016,164(1-2):69-80. doi: 10.1016/j.cell.2015.12.017
[10]	Benoit bouvrette L P,Cody N A L,Bergalet J,et al. CeFra-seq reveals broad asymmetric mRNA and noncoding RNA distribution profiles in Drosophila and human cells[J]. RNA,2018,24(1):98-113. doi: 10.1261/rna.063172.117
[11]	Dai J,Zhang S,Shi Y,et al. rs217727 of lncRNA H19 is associated with cervical cancer risk in the Chinese Han population[J]. Pharmgenomics Pers Med,2023,16(1):933-948.
[12]	Liu Y,Zhang Q,Ni R. Association between genetic variants (rs920778,rs4759314,and rs217727) in LncRNAs and cervical cancer susceptibility in Chinese population: A systematic review and meta-analysis[J]. Front Genet,2022,13(1):988207.
[13]	中华医学会. 临床诊疗指南: 妇产科学分册 [M]. 北京: 人民卫生出版社,2007: 65-67.
[14]	Yang J,Yan Z,Wang Y,et al. Association study of relationships of polymorphisms in the miR-21,miR-26b,miR-221/222 and miR-126 genes with cervical intraepithelial neoplasia and cervical cancer[J]. BMC Cancer,2021,21(1):997. doi: 10.1186/s12885-021-08743-2
[15]	Shi Y Y,He L. SHEsis,a powerful software platform for analyses of linkage disequilibrium,haplotype construction,and genetic association at polymorphism loci[J]. Cell Res,2005,15(2):97-98. doi: 10.1038/sj.cr.7290272
[16]	Solé X,Guinó E,Valls J,et al. SNPStats: A web tool for the analysis of association studies[J]. Bioinformatics,2006,22(15):1928-1929. doi: 10.1093/bioinformatics/btl268
[17]	Qi Y,Wang Z,Wu F,et al. Long noncoding RNA HOXD-AS2 regulates cell cycle to promote glioma progression[J]. J Cell Biochem,2019,120(5):8343-8351. doi: 10.1002/jcb.28117
[18]	Zhang Y,Ma H. LncRNA HOXD-AS2 regulates miR-3681-5p/DCP1A axis to promote the progression of non-small cell lung cancer[J]. J Thorac Dis,2023,15(3):1289-1301. doi: 10.21037/jtd-23-153
[19]	Paterson M R,Kriegel A J. MiR-146a/b: A family with shared seeds and different roots[J]. Physiol Genomics,2017,49(4):243-252. doi: 10.1152/physiolgenomics.00133.2016
[20]	Guo X,Zhang M,Li Q,et al. Evaluation of genetic variants in MIR3142HG in susceptibility to and prognosis of glioma[J]. Am J Clin Oncol,2020,43(1):1-8. doi: 10.1097/COC.0000000000000587
[21]	Chen Y,Zhao Y,Lu R,et al. Identification and validation of a novel genomic instability-associated long non-coding RNA prognostic signature in head and neck squamous cell carcinoma[J]. Front Cell Dev Biol,2021,9(1):787766.
[22]	Järvelin A I,Noerenberg M,Davis I,et al. The new (dis)order in RNA regulation[J]. Cell Commun Signal,2016,14(1):9. doi: 10.1186/s12964-016-0132-3
[23]	Hentze M W,Castello A,Schwarzl T,et al. A brave new world of RNA-binding proteins[J]. Nat Rev Mol Cell Biol,2018,19(5):327-341. doi: 10.1038/nrm.2017.130

Relative Articles(20)

Relative Articles

[1]	Feifei XIE, Yinzi XIN, Min XU, Jinghan LI, Wei WANG. Mechanisms of Long Non-Coding RNAs in Cartilage Development and Related Diseases. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20241001
[2]	Chao HONG, Xudong XIANG, Yingfu LI, Yang CAO, Xueya CHEN, Shuai LI, Anhao XING, Mu LIN, Qianli MA. Association of Polymorphisms in the 3' UTR of Genes in the ERK1/2 Signaling Pathway with Non-small Cell Lung Cancer. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240302
[3]	Ni GUO, Cheng ZHANG, Chao HONG, Weipeng LIU, Yufeng YAO, Zhiling YAN. Correlation of KRAS Gene 3′ UTR Polymorphisms with Cervical Cancer and Cervical Intraepithelial Neoplasia in Chinese Han Population in Yunnan Province. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240203
[4]	Zhixin NIU, Lihua TANG, Lei SHI, Chao HONG, Yufeng YAO, Zhiling YAN. Correlation of MAPK1 and NRAS Gene Polymorphisms with Cervical Intraepithelial Neoplasia in Yunnan Han Population. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240502
[5]	Tiantian CHENG, Wensa YIN, Jia WANG, Yumei LU, Xuanyu CHEN, Shengjie NIE, Linlin LIU. Association between TMTC1 Gene Polymorphisms and Schizophrenia. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20231014
[6]	Rongshuang WU, Jiangli PENG, Yonggang CHEN, Jie CHEN, Guowei MA, Xianrui LI, Xie LI, Chunhong YU. Associations between SLC2A9 Single Nucleotide Polymorphisms and Susceptibility to Pyrazinamide Induced Hyperuricemia. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20230409
[7]	Shujin LI, Yanfei YANG, Min SU, Yu LING, Yanqiong RAO, Jihua CUI. Single Nucleotide Polymorphisms in Children with Attention Deficit Hyperactivity Disorder Comorbid Emotion Problems. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20230420
[8]	Jun GU, Zexi HE, Ting LUAN, Haifeng WANG, Jiansong WANG, Mingxia DING. Research Progress of Exosomes-derived Long Non-coding RNA in Bladder Cancer. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20220110
[9]	Fangyuan GUO, Wenliang LI, Fan XU, Xiangqun WEI. The Expression and Clinical Significance of Non-coding RNA in Cervical Cancer. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20220527
[10]	Dong-yun LI, Shun-kui GANG, Jie LI, Ming-xing ZHANG, Lei LI. Association of ABCG2，SLC2A9，SLC17A3 and PRKG2 SNPs Variants with Gout in the Hani Population in China. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210320
[11]	Ding-ji TAN, Hong-li YIN, Rui ZHU, Xi ZHANG, Xin YU, Yong FEI, Xin LI, Ming DUAN, Liang HE, Hong-ying YANG. Analysis of Vaginal Microecological in Women with Cervical Intraepithelial Neoplasia and Cervical Cancer. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210821
[12]	Teng-fei ZHANG, Yue-feng HE, Lei ZHANG, Li ZHANG, Kai-yun YANG, Lian-qing LIU, Hui TAN. Expression of Long Non-coding RNA APTR，HEIH，FAS-ASA1，FAM83H-AS1，DICER1-AS1，PR-lncRNA in Lung Cancer. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210409
[13]	Zhu Sheng Zhang . Clinical Analysis of Liquid-based Cervical Cytology Examination in Cervical Cancer Screening in the South of GuiZhou. Journal of Kunming Medical University,
[14]	Hong Chao . The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer. Journal of Kunming Medical University,
[15]	Li Die Mei . The Clinical Value of Loop Electrosurgical Excision Procedure in Treating Cervical Intraepithelial Neoplasia. Journal of Kunming Medical University,
[16]	Xiang Xi . The Correlation between Vitamin D Receptor Gene FokI Single Nucleotide Polymorphism and Diabetic Kidney Disease. Journal of Kunming Medical University,
[17]	Liu Li Li . . Journal of Kunming Medical University,
[18]	Yang Xiao Lei . . Journal of Kunming Medical University,
[19]	Yang Zhi Ling . . Journal of Kunming Medical University,
[20]	Huang Ya . . Journal of Kunming Medical University,