Correlation and Predictive Value of Serum MiR-155，HBP and AECOPD Treatment Efficacy

Yang LI; Xueting YANG; Liling DING; Jie LONG

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Yang LI, Xueting YANG, Liling DING, Jie LONG. Correlation and Predictive Value of Serum MiR-155，HBP and AECOPD Treatment Efficacy[J]. Journal of Kunming Medical University.

Citation:

Yang LI, Xueting YANG, Liling DING, Jie LONG. Correlation and Predictive Value of Serum MiR-155，HBP and AECOPD Treatment Efficacy[J]. Journal of Kunming Medical University.

Yang LI, Xueting YANG, Liling DING, Jie LONG. Correlation and Predictive Value of Serum MiR-155，HBP and AECOPD Treatment Efficacy[J]. Journal of Kunming Medical University.

Citation:

Yang LI, Xueting YANG, Liling DING, Jie LONG. Correlation and Predictive Value of Serum MiR-155，HBP and AECOPD Treatment Efficacy[J]. Journal of Kunming Medical University.

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Correlation and Predictive Value of Serum MiR-155，HBP and AECOPD Treatment Efficacy

Department of Pharmacy，Yunnan First People’s Hospital/Affiliated Hospital of Kunming University of Science and Technology，Kunming Yunnan 650032，China

Received Date: 2025-09-26
Available Online: 2026-01-03

Abstract

Abstract

Objective To analyze the relationship between serum microRNA-155 （miR-155）, heparin-binding protein （HBP） and the therapeutic effect of acute exacerbation of chronic obstructive pulmonary disease （AECOPD） and its predictive value. Methods Two hundred and thirty patients with AECOPD who received treatment in the First People's Hospital of Yunnan from March 2023 to October 2024 were selected. According to the treatment effect after 10 days of treatment, they were divided into ineffective group （n = 60） and effective group （n = 170）. The general data, serum miR-155 and HBP levels before treatment were compared between the two groups. The influencing factors of ineffective treatment of AECOPD and the value of serum miR-155 and HBP in predicting ineffective treatment were analyzed. Results The levels of serum miR-155 and HBP in the ineffective group were higher than those in the effective group （P < 0.05）. The area under the curve （AUC） of serum miR-155 and HBP alone in predicting AECOPD treatment failure were 0.728 and 0.735, respectively. The AUC of miR-155 combined with HBP in predicting the ineffective treatment of AECOPD was 0.868, which was significantly higher than that of miR-155, HBP, APACHE II score, FEV1, PCT and hs-CRP alone （P < 0.05）. Conclusion The levels of serum miR-155 and HBP before treatment are independent influencing factors of ineffective treatment of AECOPD, which is helpful to predict the risk of ineffective treatment. The combination of serum miR-155 and HBP can improve the predictive value.
- Chronic obstructive pulmonary disease,
- Acute exacerbation,
- microRNA-155,
- Heparin-binding protein,
- Therapeutic effect,
- Prediction

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References(27)

References

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