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Tianyi GUO, Ran YANG, Xinwei HUANG. Dual Effects of Intratumoral Microbial Metabolism on Tumors[J]. Journal of Kunming Medical University.
Citation: Tianyi GUO, Ran YANG, Xinwei HUANG. Dual Effects of Intratumoral Microbial Metabolism on Tumors[J]. Journal of Kunming Medical University.
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Dual Effects of Intratumoral Microbial Metabolism on Tumors

  • 1.

    The Second School of Clinical Medicine

  • 2.

    School of Life Sciences and Laboratory Medicine，Kunming Medical University，Kunming Yunnan 650500

  • 3.

    Experimental Center，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

  • Received Date: 2026-04-14
    Abstract
  • Research has confirmed that tumor tissues are not in a sterile state, but rather host microbial communities with tumor-specific characteristics. These intratumoral microorganisms not only directly promote or inhibit tumorigenesis themselves, but can also influence tumor development and therapeutic responses through their active metabolic activities. This review examines the effects and mechanisms of intratumoral microbial metabolism on tumors from both pro-tumoral and anti-tumoral perspectives, and summarizes novel strategies for tumor prevention and treatment based on intratumoral microbial metabolism. The precise regulatory network of intratumoral microbial metabolism on tumors requires further investigation. Elucidating its dual effects and molecular mechanisms on tumors is expected to provide new directions for tumor prevention and treatment.
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