The Relationship between Serum sTREM-1，CCR1，LGALS3BP Expression and HBV-DNA Load，Liver Function，and Degree of Liver Fibrosis in Patients with Chronic Hepatitis B

Ying ZHANG; Pan ZHANG; Jingni ZHANG

Article Contents

Article Navigation > Journal of Kunming Medical University > 2026 > Accepted Manuscript

Ying ZHANG, Pan ZHANG, Jingni ZHANG. The Relationship between Serum sTREM-1，CCR1，LGALS3BP Expression and HBV-DNA Load，Liver Function，and Degree of Liver Fibrosis in Patients with Chronic Hepatitis B[J]. Journal of Kunming Medical University.

Citation:

PDF( 1512 KB)

The Relationship between Serum sTREM-1，CCR1，LGALS3BP Expression and HBV-DNA Load，Liver Function，and Degree of Liver Fibrosis in Patients with Chronic Hepatitis B

1.
Department of Laboratory Medicine，Xi'an First Hospital，Xi'an Shanxi 710000
2.
Xi'an Red Cross Hospital Laboratory Department，Xi'an Shanxi 710061，China

Received Date: 2025-09-29
Available Online: 2026-07-03

Abstract

Abstract

Objective To explore the relationship between the expression of soluble triggering receptor expressed on myeloid cell-1 （sTREM-1）, CC chemokine receptor 1 （CCR1）, and lectin galectin-3 binding protein （LGALS3BP） in serum and the HBV-DNA load, liver function, and degree of liver fibrosis in patients with chronic hepatitis B （CHB）. Methods Retrospective inclusion of 120 CHB patients who visited Xi'an First Hospital from March 2024 to March 2025 as samples, and detection of serum HBV-DNA load in patients. ELISA was used to detect the serum levels of sTREM-1, CCR1, and LGALS3BP. Collect liver function [aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, gamma glutamyl transferase （GGT）, total bilirubin （TBIL）], serum indicators of liver fibrosis [hyaluronic acid （HA）, laminin （LN）, collagen type IV（IV-C）, procollagen III amino terminal peptide（PC-III）], and liver stiffness measurement（LSM） were collected. The differences in various indicators among patients with different HBV-DNA loads and degrees of liver fibrosis were compared, and Pearson or Spearman correlation analysis was used to explore the correlation between indicators. The diagnostic efficacy of sTREM-1, CCR1, LGALS3BP, and LSM for liver fibrosis using ROC curves was evaluated. Results Compared with the low HBV-DNA load group, the serum levels of sTREM-1, CCR1, LGALS3BP, liver function indicators （ALT, AST, GGT, TBIL）, liver fibrosis serological indicators （HA, LN, IV-C, PC-III）, and LSM were significantly increased in the medium and high load groups （P < 0.05）. Pearson correlation analysis showed that sTREM-1, CCR1, LGALS3BP were positively correlated with HBV-DNA load, ALT, AST, GGT, TBIL, HA, LN, IV-C, and PC-III（r > 0, P < 0.05）, and there was a positive correlation （r > 0, P < 0.05）. As the degree of liver fibrosis worsened, the levels of HBV-DNA load, sTREM-1, CCR1, LGALS3BP, and LSM increased （P < 0.05）. ROC curve analysis showed that single indicators sTREM-1, CCR1, and LGALS3BP had a good predictive value for liver fibrosis, and the combined diagnostic efficacy of the three parameters was comparable to LSM. Conclusion The levels of serum sTREM-1, CCR1, and LGALS3BP are closely related to HBV-DNA load, liver function damage, degree of liver fibrosis, and LSM in CHB patients.

FullText(HTML)

References(25)

References

[1]	Wang J, Zhu L, Zhang S, et al. Clinical outcomes of treatment-naïve HBeAg-negative patients with chronic hepatitis B virus infection with low serum HBsAg and undetectable HBV DNA[J]. Emerg Microbes Infect, 2024, 13(1): 2339944. doi: 10.1080/22221751.2024.2339944
[2]	马世河, 刘文艳, 陈冲, 等. 血清GP73水平联合腹部超声检查对慢性乙型肝炎肝纤维化程度的评估价值[J]. 山东医药, 2022, 62(1): 25-29.
[3]	黄平, 曾霞, 张亚萍, 等. 肝静脉波形分型联合肝脏超声半定量评分对慢性乙型肝炎患者肝纤维化程度评估价值研究[J]. 实用肝脏病杂志, 2022, 25(2): 187-190.
[4]	Deghdegh K, Boukadoum N, Terra B, et al. Characteristics of bronchiectasis asociated with chronic obstructive pulmonary disease[J]. Open Respir Med J, 2022, 16: e187430642203311.
[5]	吴清艳, 陈柳虹, 王日, 等. HBeAg(+)与(-)HBV感染者HBV-DNA 载量及其与肝纤维化和MELD评分的关系[J]. 中华医院感染学杂志, 2023, 33(14): 2096-2099.
[6]	Wong G L, Lemoine M. The 2024 updated WHO guidelines for the prevention and management of chronic hepatitis B: Main changes and potential implications for the next major liver society clinical practice guidelines[J]. J Hepatol, 2025, 82(5): 918-925. doi: 10.1016/j.jhep.2024.12.004
[7]	Chen J, Huang Z B, Li H, et al. Early diagnostic diomarkers of sepsis for patients with acute-on-chronic liver failure: A multicenter study[J]. Infect Dis Ther, 2021, 10(1): 281-290. doi: 10.1007/s40121-020-00362-x
[8]	Tian Q, Yan Z, Guo Y, et al. Inflammatory role of CCR1 in the central nervous system[J]. Neuroimmunomodulation, 2024, 31(1): 173-182. doi: 10.1159/000540460
[9]	Kim D H, Sung M, Park M S, et al. Galectin 3-binding protein (LGALS3BP) depletion attenuates hepatic fibrosis by reducing transforming growth factor-β1 (TGF-β1) availability and inhibits hepatocarcinogenesis[J]. Cancer Commun, 2024, 44(10): 1106-1129. doi: 10.1002/cac2.12600
[10]	中华医学会肝病学分会. 慢性乙型肝炎防治指南(2015 年版)[J/OL]. 中华实验和临床感染病杂志(电子版) 2015, 19(5 ): 1-19.
[11]	陈春燕, 樊子勉. 慢性乙型肝炎者外周血 SAA/CRP、NLR 水平与HBV-DNA 载量、病情程度的相关性分析[J]. 昆明医科大学学报, 2024, 45(5): 144-150.
[12]	王慧, 郝泉水, 肖华, 等. 乙型肝炎患者血清lncRNA XIST 表达与 HBV-DNA 载量、肝纤维化的关系[J]. 中国现代医学杂志, 2025, 35(2): 78-82. doi: 10.3969/j.issn.1005-8982.2025.02.014
[13]	中华医学会肝病学分会, 中华医学会消化病学分会, 中华医学会感染病学分会. 肝纤维化诊断及治疗共识(2019年)[J]. 中华肝脏病杂志, 2019, 27(9): 657-667. doi: 10.3760/cma.j.issn.1007-3418.2019.09.001
[14]	丁艺文, 操焕坤, 宗方, 等. 二维超声剪切波弹性成像和血清学指标评分诊断慢性乙肝患者肝纤维化的价值[J]. 浙江医学, 2023, 45(18): 1937-1942.
[15]	Berzigotti A, Tsochatzis E, Boursier J, et al. EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis–2021 update[J]. J Hepatol, 2021, 75(3): 659-689. doi: 10.1016/j.jhep.2021.05.025
[16]	Chen Y C, Hsu C W, Chien R N. Higher HBeAg-reversion virological relapse and lower sustained remission after treatment cessation in tenofovir-treated HBeAg-positive patients[J]. J Med Virol, 2023, 95(11): e29213. doi: 10.1002/jmv.29213
[17]	Lai X, Chen H, Dong X, et al. AST to ALT ratio as a prospective risk predictor for liver cirrhosis in patients with chronic HBV infection[J]. Eur J Gastroenterol Hepatol, 2024, 36(3): 338-344. doi: 10.1097/MEG.0000000000002708
[18]	易爱芬, 高明. 不同Child-Pugh分级的慢性乙型肝炎合并肝硬化患者糖代谢和胰岛素分泌情况及与炎症反应相关性研究[J]. 黑龙江医学, 2023, 47(6): 663-665. doi: 10.3969/j.issn.1004-5775.2023.06.005
[19]	Dholariya S, Parchwani D N, Singh R, et al. Utility of P-SEP, sTREM-1 and suPAR as novel sepsis biomarkers in SARS-CoV-2 infection[J]. Indian J Clin Biochem, 2022, 37(2): 131-138. doi: 10.1007/s12291-021-01008-6
[20]	Khanam A, Tang L S Y, Kottilil S. Programmed death 1 expressing CD8⁺CXCR5⁺ follicular T cells constitute effector rather than exhaustive phenotype in patients with chronic hepatitis B[J]. Hepatology, 2022, 75(3): 690-708. doi: 10.1002/hep.32210
[21]	El Bannoudi H, Cornwell M, Luttrell-Williams E, et al. Platelet LGALS3BP as a mediator of myeloid inflammation in systemic lupus erythematosus[J]. Arthritis Rheumatol, 2023, 75(5): 711-722. doi: 10.1002/art.42382
[22]	何迪, 陈鹏, 刘锋, 等. 肝纤维化病因与机制研究进展[J]. 昆明医科大学学报, 2022, 43(11): 165-171. doi: 10.12259/j.issn.2095-610X.S20221122
[23]	Yu S M, Li H, Deng G H, et al. sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis[J]. World J Gastroenterol, 2024, 30(9): 1177-1188. doi: 10.3748/wjg.v30.i9.1177
[24]	Peng W, Yang Y, Lu H, et al. Network pharmacology combines machine learning, molecular simulation dynamics and experimental validation to explore the mechanism of acetylbinankadsurin A in the treatment of liver fibrosis[J]. J Ethnopharmacol, 2024, 323: 117682. doi: 10.1016/j.jep.2023.117682
[25]	Sun B, Abadjian L, Monto A, et al. Hepatitis C virus cure in human immunodeficiency virus coinfection dampens inflammation and improves cognition through multiple mechanisms[J]. J Infect Dis, 2020, 222(3): 396-406. doi: 10.1093/infdis/jiaa109

Relative Articles(20)

Relative Articles

[1]	Rui YIN, Guowei MA, Wenxi YUE, Haixia GU, Ying ZHOU, Jie CHEN. Efficacy of Nucleotide Analog Monotherapy and Combination Therapy with Interferon in Treating Chronic Hepatitis B. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20250610
[2]	Yixin WANG, Fang WANG, Xiangyan WEI, Haiyang JIANG, Airong CHEN. Study on Predictive Parameters of Liver Fibrosis Risk in Patients with Metabolic Dysfunction-associated Fatty Liver Disease Complicated with Chronic Hepatitis B. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20251015
[3]	Chunyan CHEN, Zimian FAN. Correlation Analysis of Peripheral Blood SAA/CRP and NLR Levels with HBV-DNA Lload and Degree of Disease in CHB Patients. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240522
[4]	Siqi LI, Wenlin TAI. Significance of CXCL10 as a Biomarker of Liver Cirrhosis. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20220711
[5]	Di HE, Peng CHEN, Feng LIU, Yang XU, Lei HAN, Wenjing DING. Progress in Etiology and Pathogenesis of Liver Fibrosis. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20221122
[6]	Zhi-rong ZHAO, Hai-wen LI, Ni-hong LU, Ling SHEN, Xiao-fei LI, Yong-rui YANG. A Clinical Study on the Use of Propofol Tenofovir in the Treatment of Chronic Hepatitis B. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210141
[7]	Qin XIE, Yan-ping LIANG, Yin ZHANG, Zeng-hui XU, Li-ying YOU. Efficacy of Multiple Non-invasive Diagnostic Models in the Diagnosis of Hepatic Fibrosis in Patients with Chronic Liver Diseases. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210719
[8]	Li-xian YUAN, Hong-tao ZHANG, Rui LI, Kun-rui CHEN, Kun-qian CHEN, An-shu XU. Diagnostic Efficacy of Serum PIVKA-Ⅱ Detection in Primary Hepatocellular Carcinoma. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20201223
[9]	Zhao Heng , Xu Bin , Zhao Guang Zhou , Li Rong Jie , Zhou Bai Ling , Liu Ye , Shi Shu Lan . . Journal of Kunming Medical University,
[10]	Xie Wei , Zhao Chuan , Wang Rong , Wang Wen Ping , Tu Hong . . Journal of Kunming Medical University,
[11]	Chen Zhi Bin , Mo Yan Ping , Yang Yu , Chen Can Kun , Yang Jing Yi , Wan Rui Xue , Fan Zhi Xiang , Long Li . 趋化因子受体CX3CR1基因T280M多态性在云南彝族人群中的分布. Journal of Kunming Medical University,
[12]	Yang Ke , Dan Zu Jian , Zhou Qiong Hua , Wang Jun Feng . Relationship between Soluble Cytokine Receptors, Matrix Metalloproteinases and Pancreatic Cancer. Journal of Kunming Medical University,
[13]	Sun Yue , Wei Jia , Lu Yong Ping , Wang Jin , Zou Yu , Wang Yu Xue , Yang Mi . Quantitative Analysis on Staging of Chronic Viral Hepatitis B and Hepatic Fibrosis by Real-time Shear Wave Elastography. Journal of Kunming Medical University,
[14]	Ning Lin . . Journal of Kunming Medical University,
[15]	He Min . . Journal of Kunming Medical University,
[16]	Liu Dong . . Journal of Kunming Medical University,
[17]	Li Ming Ming . . Journal of Kunming Medical University,
[18]	Su Ying . . Journal of Kunming Medical University,
[19]	Zeng Jin . . Journal of Kunming Medical University,
[20]	Li Wu . . Journal of Kunming Medical University,