Correlation and Diagnostic Performance of Inflammatory Cytokines in Relation to Bone Mineral Density and β-CTX in Postmenopausal Women with Type 2 Diabetes Mellitus

Kaige ZHANG; Ruonan LI; Jialin CHEN; Deping FENG; Yu LIU

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Kaige ZHANG, Ruonan LI, Jialin CHEN, Deping FENG, Yu LIU. Correlation and Diagnostic Performance of Inflammatory Cytokines in Relation to Bone Mineral Density and β-CTX in Postmenopausal Women with Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University.

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Correlation and Diagnostic Performance of Inflammatory Cytokines in Relation to Bone Mineral Density and β-CTX in Postmenopausal Women with Type 2 Diabetes Mellitus

Kaige ZHANG^{1, 2},
Ruonan LI^{2
,
,},
Jialin CHEN¹,
Deping FENG^{1, 2},
Yu LIU^{1, 2}

1.
Clinical Medical College，Dali University，Dali Yunnan 671003
2.
Department of Endocrinology，The Third People’s Hospital of Yunnan，Kunming Yunnan 650011，China

Received Date: 2024-11-04

Abstract

Abstract

Objective To analyze the correlation between inflammatory factors and bone mineral density （BMD） as well as β-C-terminal telopeptide of type I collagen （β-CTX） in postmenopausal patients with type 2 diabetes mellitus （T2DM）, and to evaluate the diagnostic efficacy of the inflammatory factors in postmenopausal T2DM patients with osteoporosis （OP）. Methods A total of 538 postmenopausal women with T2DM, hospitalized in the Department of Endocrinology at the Third People's Hospital of Yunnan Province from October 1, 2023 to August 31, 2024, were screened, and 181 were ultimately included in the study. Based on bone mineral density, they were divided into the osteopenia group （86 patients, -2.5<T<-1.0） and the osteoporosis group （95 patients, T≤-2.5）. Demographic data, inflammation-related indicators, bone metabolism markers, and other clinical parameters were collected and recorded. Results （1） The differences were statistically significant in age, duration of T2DM, body mass index （BMI）, C-reactive protein （CRP）, interleukin-6 （IL-6）, neutrophil-to-lymphocyte ratio （NLR）, monocyte-to-lymphocyte ratio （MLR）, systemic immune-inflammation index （SII）, β-CTX, parathyroid hormone （PTH）, and BMD at various sites between the two groups （P < 0.05）; （2） Spearman correlation analysis results indicated that CRP, IL-6, NLR, MLR, and SII were negatively correlated with bone mineral density （P < 0.05）, and in the osteoporosis group, CRP and IL-6 were positively correlated with β-CTX （P < 0.05）; （3） Multifactorial binary logistic regression analysis showed that CRP, IL-6, SII, age, and β-CTX were independent risk factors for the occurrence of OP in both groups （OR > 1, B > 0）, while BMI was an independent protective factor for the occurrence of OP （OR < 1, B < 0）; （4） ROC curve analysis showed that CRP, IL-6, NLR, MLR, and SII all demonstrated diagnostic efficacy for postmenopausal T2DM patients with osteoporosis, among which the combined detection model of CRP, IL-6, and SII exhibited the highest diagnostic efficacy. Conclusion Inflammatory markers are correlated with bone mineral density and β-CTX levels, and may have predictive value for diagnosing osteoporosis in postmenopausal T2DM patients.
- Inflammatory factors,
- Postmenopausal type 2 diabetes mellitus,
- Osteoporosis,
- Correlation,
- Diagnostic efficacy

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References(38)

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