The Role of Intestinal Flora and Its Metabolites in The Development of Atherosclerosis

Aiyun WANG; Yuting WANG; Jing CAI; Ruoyan NI; Caiying LUO; Zhuo YU; Peng CHEN

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Aiyun WANG, Yuting WANG, Jing CAI, Ruoyan NI, Caiying LUO, Zhuo YU, Peng CHEN. The Role of Intestinal Flora and Its Metabolites in The Development of Atherosclerosis[J]. Journal of Kunming Medical University.

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Aiyun WANG, Yuting WANG, Jing CAI, Ruoyan NI, Caiying LUO, Zhuo YU, Peng CHEN. The Role of Intestinal Flora and Its Metabolites in The Development of Atherosclerosis[J]. Journal of Kunming Medical University.

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The Role of Intestinal Flora and Its Metabolites in The Development of Atherosclerosis

Aiyun WANG^{1, 2},
Yuting WANG^{1, 2},
Jing CAI^{1, 2},
Ruoyan NI^{1, 2},
Caiying LUO^{1, 2},
Zhuo YU^{3
,
,},
Peng CHEN^{1, 2
,
,}

1.
School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Medical University
2.
College of Modern Biomedical Industry，Kunming Medical University，Kunming Yunnan 650500
3.
Dept. of Cardiology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2024-09-23
Available Online: 2024-12-10

Abstract

Abstract

Intestinal flora and their metabolites play an important role in the occurrence and development of cardiovascular diseases such as atherosclerosis （AS）, and have become an important target for the prevention and treatment of AS. In this paper, we focus on the intestinal microecological environment and focus on the relationship between intestinal flora metabolites such as trimethylamine oxide （TMAO）, short-chain fatty acids （SCFA）, phenylacetylglutamine （PAG）, lipopolysaccharides （LPS）, and bile acids （BA）, and AS. At the same time, we also discuss the therapeutic strategies of AS that start from adjusting the intestinal flora and its metabolites, with the hope of opening up a new avenue of AS prevention and treatment. We hope to open up new avenues for the prevention and treatment of AS.
- Intestinal flora,
- Metabolites,
- Atherosclerosis,
- Treatment

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References(40)

References

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