Prognostic Value of Soluble Growth Stimulating Express Gene 2 Protein and Growth Hormone/Insulin-Like Growth Factor in Peripheral Blood for Prostate Cancer

Yu WANG; Zhanfang GUO; Zhen ZHANG; Cunyuan DONG; Tao LIU

Article Contents

Article Navigation > Journal of Kunming Medical University > 2026 > Accepted Manuscript

Yu WANG, Zhanfang GUO, Zhen ZHANG, Cunyuan DONG, Tao LIU. Prognostic Value of Soluble Growth Stimulating Express Gene 2 Protein and Growth Hormone/Insulin-Like Growth Factor in Peripheral Blood for Prostate Cancer[J]. Journal of Kunming Medical University.

Citation:

PDF( 719 KB)

Prognostic Value of Soluble Growth Stimulating Express Gene 2 Protein and Growth Hormone/Insulin-Like Growth Factor in Peripheral Blood for Prostate Cancer

1.
Department of Nuclear Medicine
2.
Department of Ultrasound Medicine
3.
Department of Laboratory Medicine，Zhangjiakou First Hosptail，Zhangjiakou Hebei 075000，China

Received Date: 2026-01-15

Abstract

Abstract

Objective To explore the predictive value of soluble growth stimulating express gene 2 protein （sST2） and growth hormone （GH）/insulin-like growth factors （IGF-I） in peripheral blood for the prognosis of prostate cancer. Methods A total of 153 prostate cancer patients admitted to the Department of Urology at the First Hospital of Zhangjiakou from January 2022 to January 2023 were enrolled as study subjects. Based on the 2-year postoperative prognosis, patients were divided into a good prognosis group （n = 126） and a poor prognosis group （n = 27）. Clinical data were collected, and univariate analysis was conducted to identify adverse prognostic factors for prostate cancer. Multivariate logistic regression analysis was employed to determine independent risk factors for poor prognosis. ROC curve analysis was performed to assess the predictive value of serum sST2, GH, and IGF-I levels for poor prostate cancer prognosis. Results Among the 153 prostate cancer patients, 126 exhibited a favorable 2-year postoperative prognosis, while 27 had an unfavorable prognosis. Univariate analysis revealed that the unfavorable prognosis group had significantly higher proportions of Gleason score ≥7, preoperative PSA levels, sST2, GH, and IGF-I levels compared to the favorable prognosis group （P < 0.05）. Preoperative PSA levels, sST2, GH, and IGF-I were identified as independent risk factors for poor prostate cancer prognosis （P < 0.05）. The area under the receiver operating characteristic curve （AUC） of sST2, GH, and IGF-I alone, and in combination were 0.843 （95%CI: 0.761～0.926）, 0.768 （95%CI: 0.647～0.889）, 0.775 （95%CI: 0.674～0.875）, and 0.920 （95%CI: 0.844～0.996）, respectively. The combined AUC was significantly greater than the individual measurements （P < 0.05）. Conclusion sST2, GH, and IGF-I are independent risk factors for poor prostate cancer prognosis. Combined detection of three three biomarkers demonstrates high predictive efficacy for poor prostate cancer prognosis.
- Prostate cancer,
- Soluble growth stimulating gene 2 protein expression,
- Growth hormone,
- Insulin-like growth factor,
- Prognostic prediction

FullText(HTML)

References(22)

References

[1]	张灿峰, 刘嘉欣, 杨文博. miR-296-5p、Skp2、RPL6与前列腺癌病理特征的关系及对手术预后的影响[J]. 重庆医科大学学报, 2025, 50(2): 198-203.
[2]	Chen H, Pang B, Zhou C, et al. Prostate cancer-derived small extracellular vesicle proteins: The hope in diagnosis, prognosis, and therapeutics[J]. J Nanobiotechnol, 2023, 21(1): 480. doi: 10.1186/s12951-023-02219-0
[3]	朱文雄, 徐文静, 张熙, 等. 基于非经典Wnt信号通路探究益肾通癃汤对雄激素非依赖性前列腺癌荷瘤裸鼠细胞增殖与凋亡的影响[J]. 国际中医中药杂志, 2025, 47(10): 1404-1411.
[4]	Vazquez-Urrutia J R, Torres-Bustamante M I, Cerda-Cruz C R, et al. The role of miRNAin prostate cancer diagnosis, prognosis and treatment response: A narrative review[J]. Future Oncol, 2023, 19(1): 77-93. doi: 10.2217/fon-2022-0891
[5]	陈少秀, 饶红, 陈德森. 淫羊藿苷对BALB/c-nu裸小鼠雄激素依赖性前列腺癌雄激素受体信号转导通路的影响[J]. 长春中医药大学学报, 2018, 34(3): 436-438. doi: 10.13463/j.cnki.cczyy.2018.03.009
[6]	江琴, 周敏, 王媛, 等. 全身免疫炎症指数和预后营养指数对晚期前列腺癌病人预后的预测价值[J]. 护理研究, 2025, 39(3): 353-360.
[7]	赵涛, 廖度悟, 杨剑波, 等. 前列腺癌组织中RBMS1的表达与患者临床病理特征及预后的关系[J]. 河北医学, 2025, 31(2): 286-290.
[8]	Boyer M J, Carpenter D J, Gingrich J R, et al. Genomic classifiers and prognosis of localized prostate cancer: A systematic review[J]. Prostate Cancer Prostatic Dis, 2025, 28(1): 103-111. doi: 10.1038/s41391-023-00766-z
[9]	马婧, 宋争放, 王霄. 前列腺癌美国、欧洲、日本指南与中国诊疗指南对比研究[J]. 四川医学, 2022, 43(5): 511-514.
[10]	Ye L, Sanders A J, Jiang W G. Transglutaminase-4 (prostate transglutaminase), a potential biological factor and clinical indicator for the diagnosis and prognosis of prostate cancer[J]. Anticancer Res, 2023, 43(1): 291-296. doi: 10.21873/anticanres.16162
[11]	贾媛, 王洪福, 刘楠, 等. 前列腺癌组织中ABCC4、miR-125b-5p表达水平与患者术后预后的关系[J]. 国际检验医学杂志, 2024, 45(10): 1159-1164+1170. doi: 10.3969/j.issn.1673-4130.2024.10.002
[12]	张丽, 杜波, 杜凌云. 前列腺健康指数、PSAD和血清GPC-3对行前列腺癌根治术患者预后的预测价值[J]. 临床和实验医学杂志, 2024, 23(22): 2401-2404.
[13]	兰乐健, 尤升杰, 桂志红, 等. 碱性磷酸酶、乳酸脱氢酶及Gleason分级用于评估低风险转移性激素敏感型前列腺癌预后的价值[J]. 中国性科学, 2024, 33(4): 34-37.
[14]	Franzese C, Cozzi L, Badalamenti M, et al. Radiomics-based prognosis classification for high-risk prostate cancer treated with radiotherapy[J]. Strahlenther Und Onkol, 2022, 198(8): 710-718. doi: 10.1007/s00066-021-01886-y
[15]	郭晓翔, 朱海松, 张超, 等. 血清前列腺特异性抗原和α-甲酰辅酶A消旋酶水平对前列腺癌根治术后患者预后的预测价值[J]. 新乡医学院学报, 2023, 40(11): 1056-1060.
[16]	Wang X, Jordahl K M, Zhu C, et al. Methylation subtypes of primary prostate cancer predict poor prognosis[J]. Cancer Epidemiol Biomarkers Prev., 2022, 31(7): 1473-1482. doi: 10.1158/1055-9965.EPI-22-0007
[17]	孙琦景, 吴春磊, 何岩, 等. 前列腺癌患者miRNA-218表达水平与临床-病理特征及预后的关系[J]. 中国性科学, 2024, 33(5): 22-26. doi: 10.3969/j.issn.1672-1993.2024.05.006
[18]	王潇然, 陆巍, 于欣, 等. NRG1、HER3在前列腺癌组织中的表达及其与临床病理特征和预后的关系[J]. 疑难病杂志, 2024, 23(1): 63-67. doi: 10.3969/j.issn.1671-6450.2024.01.011
[19]	Zhou S, Sun L, Mao F, et al. Sphingolipids in prostate cancer prognosis: Integrating single-cell and bulk sequencing[J]. Aging, 2024, 16(9): 8031-8043. doi: 10.18632/aging.205803
[20]	Rocca C, Rocca G, Zampieri P, et al. Somatic and germline variants affect prognosis and susceptibility in prostate cancer[J]. Anticancer Res, 2023, 43(7): 2941-2949. doi: 10.21873/anticanres.16465
[21]	程元辉, 刘峰, 江琴, 等. 预后营养指数和HALP评分与中晚期前列腺癌病人预后的关系: 一项多中心回顾性研究[J]. 肠外与肠内营养, 2024, 31(4): 239-244, 251.
[22]	Pirouzpanah M B, Babaie S, Pourzeinali S, et al. Harnessing tumor-derived exosomes: A promising approach for the expansion of clinical diagnosis, prognosis, and therapeutic outcome of prostate cancer[J]. BioFactors, 2024, 50(4): 674-692. doi: 10.1002/biof.2036

Relative Articles(20)

Relative Articles

[1]	Haiying ZHAO, Jianrong LIU, Yang XIANG. Effects of Erianin on Ferroptosis in Prostate Cancer Cells via the Keap1/Nrf2/HO-1 Signaling Pathway. Journal of Kunming Medical University,
[2]	Liyue REN, Mingzhi ZHAO, Sijie WANG, Qin LIU, Jiajia LIU. Network Pharmacological Study on Active Compounds of Astragalus and Magnolia officinalis Against Prostate Cancer. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20250907
[3]	Wei WANG, Sheng LIU, Hongqing ZHOU, Mingsheng LIU, Pingbo XIE, Feng GUO, Guanyu CHEN. Clinical Efficacy of Immediate Radical Surgery for Locally Advanced Prostate Cancer. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20250106
[4]	Jiantong ZHANG, Zhenzhuang GAO, Zhixiu WANG, Lina SUN. Investigating the Effect of Dihydroartemisinin on Proliferation and Metastasis of Prostate Cancer Cells based on the SPOP/HnRNPK Pathway. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20251104
[5]	Bin ZHAO, Yuanpeng DUAN, Guoying ZHANG, Chengwei BI, Libo YANG, Zhiyu SHI, Yong YANG, Jianpeng ZHANG, Ting GAO. CircRNA EZH2 Promotes Proliferation and Migration of Prostate Cancer Cells by Regulating miR-30c-5p. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20220731
[6]	Jun ZHONG, Jing-yun FU. The Pathogenesis of Acromegaly Complicated with Diabetes Mellitus. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210529
[7]	Sun Jian Wei , Wang Jian Song , Liu Zi Chao , Zheng Li Min . . Journal of Kunming Medical University,
[8]	Li Hui , Ping Qin Rong , Shi Yun Qiang , Wang Chun Hui , Yang Yang , Hu Li Bing , Bi Xiao Fang , Li Jian , Zhong Yi Ming . . Journal of Kunming Medical University,
[9]	Ran Zhen , Zhu Yun Sha , Hai Bing , Zhang Jing Song . Relationship between the Proportion of Tumor Infiltrating Lymphocytes in Tumor Mass and Postoperative Recurrence of Prostate Carcinoma. Journal of Kunming Medical University,
[10]	Zhao Bin , Li Rui Qian , Zhang Guo Ying , Lei Yong Hong , Wang Qi Lin , Liu Zhi Min . Overexpression of miR-4328 Inhibits the Proliferation, Migration and Epithelial Mesenchymal Transition of Prostate Cancer Cells. Journal of Kunming Medical University,
[11]	Ma Yin Rui . . Journal of Kunming Medical University,
[12]	Zhang Jing Song . . Journal of Kunming Medical University,
[13]	Shen Hong . . Journal of Kunming Medical University,
[14]	Lei Jing . . Journal of Kunming Medical University,
[15]	Du Xiong . . Journal of Kunming Medical University,
[16]	Liu Peng Jie . . Journal of Kunming Medical University,
[17]	Sun Jian Wei . . Journal of Kunming Medical University,
[18]	Liu Xiao Dong . . Journal of Kunming Medical University,
[19]	Yang Xiao Ling . . Journal of Kunming Medical University,
[20]	He Bao Li . . Journal of Kunming Medical University,