Clinical Efficacy of Short-term Spinal Cord Stimulation and Dorsal Root Ganglion Stimulation in the Treatment of Herpes Zoster-related Neuralgia and Improvement of Sleep Quality

Wenbiao HAN; Wenjuan HAN; Hongchen SHI; Liqin GAO; Xiaohui LIU; Junpeng LIU; Yunpeng MA

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Wenbiao HAN, Wenjuan HAN, Hongchen SHI, Liqin GAO, Xiaohui LIU, Junpeng LIU, Yunpeng MA. Clinical Efficacy of Short-term Spinal Cord Stimulation and Dorsal Root Ganglion Stimulation in the Treatment of Herpes Zoster-related Neuralgia and Improvement of Sleep Quality[J]. Journal of Kunming Medical University.

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Clinical Efficacy of Short-term Spinal Cord Stimulation and Dorsal Root Ganglion Stimulation in the Treatment of Herpes Zoster-related Neuralgia and Improvement of Sleep Quality

1.
Department of Pain Management
2.
Department of Psychiatry and Psychology
3.
Department of Plastic Surgery，The Second Hospital of Hebei Medical University，Shijiazhuang Hebei 050000，China

Abstract

Abstract

Objective To explore the clinical efficacy and impact on sleep quality of short-term spinal cord stimulation （stSCS） and short-term dorsal root ganglion stimulation （stDRG） in treating zoster associated neuralgia （ZAN）. Methods A total of 124 patients with ZAN diagnosed and treated at the Second Hospital of Hebei Medical University between September 2022 and May 2024 were selected and divided into Group A （stSCS） and Group B （stDRG） according to different treatment modalities, with 62 cases in each group. After propensity score matching （PSM） to balance covariates between groups, clinical efficacy was compared. Changes in visual analogue scale （VAS）, pain-DETECT questionnaire （PD-Q）, Hamilton anxiety scale （HAMA）, Hamilton depression scale （HAMD） scores, inflammatory indicators, phosphatidylinositol-3-kinase （PI3K）/protein kinase B （AKT）/mammalian target of rapamycin （mTOR） signaling pathway indicators and polysomnography parameters before and after treatment were analyzed, and the correlation between each indicator and PSOI score was explored. Results There was no statistically significant difference in clinical efficacy, long-term recurrence rate and adverse reactions between the two groups （P > 0.05）. Difference-in-differences （DID） analysis showed no significant baseline differences in VAS, PD-Q, HAMA, and HAMD scores between groups （P > 0.05）; all scores significantly improved over time, and the net effects of different treatment methods on each score were evident （P < 0.05）. Repeated-measures ANOVA showed that the inflammatory indicators, PI3K/AKT/mTOR signaling pathway indicators, and polysomnography parameters in both groups changed significantly over time, with evident between-group and interaction effects （P < 0.05）. earson correlation analysis demonstrated stable correlations between PSQI, VAS, PD-Q, HAMA, and HAMD scores and inflammatory markers, PI3K/AKT/mTOR signaling pathway indicators, and polysomnography parameters （P < 0.05）. Conclusion Both stSCS and stDRG can effectively improve quality of life of ZAN patients, with stSCS demonstrating greater advantages in sustained analgesic efficacy and stable sleep-improving effects.

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References(28)

References

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