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Rui YANG, Mou WANG, Yifan YANG, Tao DING, Shengliu SHI, Jing XU. The Moderating Effect of Pain Frequency on Sleep Quality and Anxiety in Young Adults with Chronic Low Back Pain[J]. Journal of Kunming Medical University.
Citation: Rui YANG, Mou WANG, Yifan YANG, Tao DING, Shengliu SHI, Jing XU. The Moderating Effect of Pain Frequency on Sleep Quality and Anxiety in Young Adults with Chronic Low Back Pain[J]. Journal of Kunming Medical University.

The Moderating Effect of Pain Frequency on Sleep Quality and Anxiety in Young Adults with Chronic Low Back Pain

  • Received Date: 2025-08-06
  •   Objective  To investigate the correlation between sleep quality and anxiety symptoms in young adults with chronic low back pain (CLBP), and to analyze the moderating effect of pain frequency in the sleep-anxiety relationship.   Methods  A cross-sectional study design was employed, and a questionnaire survey was conducted among 150 young CLBP patients (aged 18 ~ 44 years) who attended the Rehabilitation Medicine Department of the First Affiliated Hospital of Kunming Medical University from September 2024 to May 2025. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), while anxiety levels were measured with the Self-rating Anxiety Scale (SAS). Statistical analyses included non-parametric tests, Spearman correlation analysis, and Process macro (version 4.2).   Results  A significantly positive correlation was demonstrated between the total PSQI score and the total SAS score (rs = 0.385, P < 0.01). Low back pain frequency demonstrated significantly positive correlations with both the PSQI total score (rs = 0.399) and the sleep disturbance dimension (rs = 0.490, P < 0.01). No statistically significant differences in sleep or anxiety were found based on gender or age (P > 0.05). Hierarchical regression analysis revealed that the interaction term between PSQI and low back pain frequency had a significant positive predictive effect on SAS (β = 0.133, P < 0.05). PSQI scores significantly predicted SAS scores across different levels of low back pain frequency (95% CI did not include 0).   Conclusions  Sleep quality is correlated with anxiety in young adults with CLBP, and pain frequency plays a moderating role in the sleep-anxiety relationship. Increased frequency of low back pain may exacerbate sleep problems, thereby contributing to anxiety. This suggests that pain frequency should be regarded as an important early warning indicator in clinical intervention.
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  • [1]
    Kechagias D, Chatzipapas C, Karaglani M, et al. Efficacy of bioelectrical impedance analysis for the evaluation of physical impairment in chronic low back pain. results from a cohort study[J]. Folia Med, 2021, 63(6): 919-927. doi: 10.3897/folmed.63.e59311
    [2]
    Goodin B R, Overstreet D S, Penn T M, et al. Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain[J]. Clin Epigenetics, 2022, 14(1): 45. doi: 10.1186/s13148-022-01265-z
    [3]
    Calvo-Muñoz I, Kovacs F M, Roqué M, et al. Risk factors for low back pain in childhood and adolescence: A systematic review[J]. Clin J Pain, 2018, 34(5): 468-484. doi: 10.1097/AJP.0000000000000558
    [4]
    Wang L Y, Fu T S, Tsia M C, et al. The associations of depression, anxiety, and insomnia at baseline with disability at a five-year follow-up point among outpatients with chronic low back pain: A prospective cohort study[J]. BMC Musculoskelet Disord, 2023, 24(1): 565. doi: 10.1186/s12891-023-06682-6
    [5]
    Xu C, Fu Z, Wang J, et al. Differences and correlations of anxiety, sleep quality, and pressure-pain threshold between patients with chronic low back pain and asymptomatic people[J]. Pain Res Manag, 2022, 2022: 8648584.
    [6]
    Burgess H J, Burns J W, Buvanendran A, et al. Associations between sleep disturbance and chronic pain intensity and function: A test of direct and indirect pathways[J]. Clin J Pain, 2019, 35(7): 569-576. doi: 10.1097/AJP.0000000000000711
    [7]
    Yoo Y M, Kim K H. Current understanding of nociplastic pain[J]. Korean J Pain, 2024, 37(2): 107-118. doi: 10.3344/kjp.23326
    [8]
    Čeko M, Baeuerle T, Webster L, et al. The effects of virtual reality neuroscience-based therapy on clinical and neuroimaging outcomes in patients with chronic back pain: A randomized clinical trial[J]. Pain, 2024, 165(8): 1860-1874. doi: 10.1097/j.pain.0000000000003198
    [9]
    国家卫生健康委能力建设和继续教育中心疼痛病诊疗专项能力提升项目专家组, 程志祥, 刘先国, 等. 中国慢性腰背痛诊疗指南(2024版)[J]. 中华疼痛学杂志, 2024, 20(01): 4-22. doi: 10.3760/cma.j.issn.1000-8039.2024.08.110
    [10]
    Buysse D J, Reynolds C F, Monk T H, et al. The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research[J]. Psychiatry Res, 1989, 28(2): 193-213. doi: 10.1016/0165-1781(89)90047-4
    [11]
    路桃影, 李艳, 夏萍, 等. 匹兹堡睡眠质量指数的信度及效度分析[J]. 重庆医学, 2014, 43(3): 260-263. doi: 10.3969/j.issn.1671-8348.2014.03.002
    [12]
    Ghrouz A K, Noohu M M, Dilshad Manzar M, et al. Physical activity and sleep quality in relation to mental health among college students[J]. Sleep Breath, 2019, 23(2): 627-634. doi: 10.1007/s11325-019-01780-z
    [13]
    Zung W W. A rating instrument for anxiety disorders[J]. Psychosomatics, 1971, 12(6): 371-379. doi: 10.1016/S0033-3182(71)71479-0
    [14]
    王芳芳. 焦虑自评量表在中学生中的测试[J]. 中国学校卫生, 1994, 15(3): 202-203.
    [15]
    Xu J, Wei Y. Social support as a moderator of the relationship between anxiety and depression: An empirical study with adult survivors of Wenchuan earthquake[J]. PLoS One, 2013, 8(10): e79045. doi: 10.1371/journal.pone.0079045
    [16]
    Sessler K, Blechschmidt V, Hoheisel U, et al. Spinal cord fractalkine (CX3CL1) signaling is critical for neuronal sensitization in experimental nonspecific, myofascial low back pain[J]. J Neurophysiol, 2021, 125(5): 1598-1611. doi: 10.1152/jn.00348.2020
    [17]
    Jefferson T, Kelly C J, Martina M. Differential rearrangement of excitatory inputs to the medial prefrontal cortex in chronic pain models[J]. Front Neural Circuits, 2021, 15: 791043. doi: 10.3389/fncir.2021.791043
    [18]
    Faria V, Ahs F, Appel L, et al. Amygdala-frontal couplings characterizing SSRI and placebo response in social anxiety disorder[J]. Int J Neuropsychopharmacol, 2014, 17(8): 1149-1157. doi: 10.1017/S1461145714000352
    [19]
    Presto P, Mazzitelli M, Junell R, et al. Sex differences in pain along the neuraxis[J]. Neuropharmacology, 2022, 210: 109030. doi: 10.1016/j.neuropharm.2022.109030
    [20]
    Bautista-Abad Á, García-Magro N, Pinto-Benito D, et al. Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input[J]. Geroscience, 2024, 46(6): 6459-6472. doi: 10.1007/s11357-024-01268-z
    [21]
    Ferrari E, Cravello L, Muzzoni B, et al. Age-related changes of the hypothalamic-pituitary-adrenal axis: Pathophysiological correlates[J]. Eur J Endocrinol, 2001, 144(4): 319-329. doi: 10.1530/eje.0.1440319
    [22]
    Pinto S M, Cheung J P Y, Samartzis D, et al. Are morphometric and biomechanical characteristics of lumbar multifidus related to pain intensity or disability in people with chronic low back pain after considering psychological factors or insomnia?[J]. Front Psychiatry, 2022, 13: 809891. doi: 10.3389/fpsyt.2022.809891
    [23]
    Zheng P, Scheffler A, Ewing S, et al. Chronic low back pain causal risk factors identified by Mendelian randomization: A cross-sectional cohort analysis[J]. Spine J, 2025, 25(6): 1154-1166. doi: 10.1016/j.spinee.2024.12.029
    [24]
    Fatemeh G, Sajjad M, Niloufar R, et al. Effect of melatonin supplementation on sleep quality: A systematic review and meta-analysis of randomized controlled trials[J]. J Neurol, 2022, 269(1): 205-216. doi: 10.1007/s00415-020-10381-w
    [25]
    Cheng Z, Xiang Q, Wang J, et al. The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review[J]. Ageing Res Rev, 2021, 70: 101394. doi: 10.1016/j.arr.2021.101394
    [26]
    Maurer L F, Schneider J, Miller C B, et al. The clinical effects of sleep restriction therapy for insomnia: A meta-analysis of randomised controlled trials[J]. Sleep Med Rev, 2021, 58: 101493. doi: 10.1016/j.smrv.2021.101493
    [27]
    Goudman L, De Smedt A, Jansen J, et al. Virtual reality to improve sleep quality in patients suffering from painful diabetic polyneuropathy: A proof of concept study[J]. J Clin Med, 2024, 13(23): 7163. doi: 10.3390/jcm13237163
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