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Yuanzhen WANG, Hongyan WEI, Renhai TIAN, Yongzhen Chen, Danqing XU, Yingyuan ZHANG, Lixian CHANG, Chunyun LIU, Li LIU. Establishment and Evaluation of a Risk Prediction Model for Chronic Liver Failure Complicated by Primary Hepatocellular Carcinoma Before Intervention[J]. Journal of Kunming Medical University.
Citation: Yingfu LI, Ni GUO, Zhengguang LUO, Anhao XING, Taifu LI, Qianli MA. Correlation of EGFR Gene Polymorphisms with Non-small Cell Lung Cancer in Yunnan Han Population[J]. Journal of Kunming Medical University.
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Correlation of EGFR Gene Polymorphisms with Non-small Cell Lung Cancer in Yunnan Han Population

  • 1.

    Department of Geriatrics，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032

  • 2.

    Baoshan College of Traditional Chinese Medicine，Baoshan Yunnan 678000

  • 3.

    Department of Thoracic Surgery，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118

  • 4.

    Anning Taiping Health Center，Anning Yunnan 650301，China

    Abstract
  •   Objective  To investigate the correlation between the epidermal growth factor receptor （EGFR） gene polymorphisms and non-small cell lung cancer （NSCLC） in Yunnan Han population.   Methods  A total of 407 NSCLC patients and 526 healthy controls were included. Five SNPs （rs1050171, rs2072454, rs2227983, rs1140475 and rs2293347） in EGFR were genotyped using TaqMan assay. The association between SNPs and NSCLC, as well as pathological types, were analyzed.   Results  In dominant mode, rs2072454 C/T-T/T may be a risk factor for NSCLC （P = 0.004; OR = 1.50, 95% CI 1.14～1.96）. There was a significant difference in genotype frequency between the SCC group and the control group （P = 0.007）, but no difference in allele frequency after Bonferroni correction （P > 0.01）; In the dominant mode, C/T-T/T at this locus relative to C/C was a risk for AC （P = 0.002; OR = 1.86, 95% CI 1.24～2.80）. rs1050171 A/A had a significantly higher risk of SCC in recessive mode （P = 0.006, OR = 2.66, 95% CI 1.33～5.33）. In dominant mode, rs2227983 A/G-G/G/G was a risk factor for the development of SCC relative to A/A （P = 0.007; OR = 1.83, 95% CI 1.15～2.89）.   Conclusion  The SNPs rs2072454, rs1050171 and rs2227983 in EGFR gene may be associated with the risk of NSCLC development as well as the type of pathology in Yunnan Han population.
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