Correlation Between Metabolic Syndrome and Diabetic Retinopathy

Chunhui ZHANG; Long YANG; Xu ZHA; Liqiong ZHOU; Quan CHENG; Yuanping ZHANG

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Chunhui ZHANG, Long YANG, Xu ZHA, Liqiong ZHOU, Quan CHENG, Yuanping ZHANG. Correlation Between Metabolic Syndrome and Diabetic Retinopathy[J]. Journal of Kunming Medical University.

Citation:

Chunhui ZHANG, Long YANG, Xu ZHA, Liqiong ZHOU, Quan CHENG, Yuanping ZHANG. Correlation Between Metabolic Syndrome and Diabetic Retinopathy[J]. Journal of Kunming Medical University.

Chunhui ZHANG, Long YANG, Xu ZHA, Liqiong ZHOU, Quan CHENG, Yuanping ZHANG. Correlation Between Metabolic Syndrome and Diabetic Retinopathy[J]. Journal of Kunming Medical University.

Citation:

Chunhui ZHANG, Long YANG, Xu ZHA, Liqiong ZHOU, Quan CHENG, Yuanping ZHANG. Correlation Between Metabolic Syndrome and Diabetic Retinopathy[J]. Journal of Kunming Medical University.

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Correlation Between Metabolic Syndrome and Diabetic Retinopathy

1.
Department of Ophthalmology，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650033
2.
Department of Ophthalmology and Otorhinolaryngology，Kunming Maternal and Child Health Care Hospital，Kunming Yunnan 650021，China

Received Date: 2025-10-10
Available Online: 2026-01-20

Abstract

Abstract

Objective To analyze the correlation between metabolic syndrome （MS） and its components with the risk of diabetic retinopathy （DR） in patients with type 2 diabetes mellitus （T2DM）. Methods A retrospective analysis was conducted on clinical data of 2441 T2DM patients hospitalized in the Departments of Ophthalmology and Endocrinology at the Second Affiliated Hospital of Kunming Medical University from January 2019 to October 2024. Based on fundoscopic findings, enrolled patients were divided into DR group （n = 619） and NDR group （n = 1,591）. Univariate analysis was used to compare the detection rates of metabolic syndrome （MS） and its components between the two patient groups. Logistic regression analysis was performed to assess the correlation between MS and its components with the risk of diabetic retinopathy （DR）. Results According to the NECP-ATP III criteria, among 2, 210 T2DM patients, 619 had DR, and 514 had concurrent MS, with a detection rate of 83.00%. The detection rates of concurrent MS, elevated blood pressure, elevated triglycerides （TG）, and decreased high-density lipoprotein cholesterol （HDL-C） in the DR group were all significantly higher than those in the NDR group, with statistically significant differences （P < 0.05）. After adjusting for confounding factors in multivariate Logistic regression analysis, concurrent MS, hypertension, elevated TG, and decreased HDL-C were all significantly positively associated with the risk of DR, with OR values and 95%CI of 2.025 （1.462～2.806）, 2.879 （2.316～3.578）, 2.259 （1.803～2.829）, and 2.500 （1.993～3.136）, respectively. Conclusion MS is associated with the occurrence of DR in T2DM patients, with elevated blood pressure, elevated TG, and reduced HDL-C being particularly significant. As the number of MS components increases, the risk of DR shows an increasing trend.
- Diabetic retinopathy,
- Metabolic syndrome,
- Type 2 diabetes mellitus

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References(35)

References

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