Levels of IGF-1 and IGFBP-3 in Childhood Obesity and Their Diagnostic Value

Lisi LUO; Qingxiong YANG; Yan WANG; Sixiang LIU; Zhen XU; Yu LING

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Lisi LUO, Qingxiong YANG, Yan WANG, Sixiang LIU, Zhen XU, Yu LING. Levels of IGF-1 and IGFBP-3 in Childhood Obesity and Their Diagnostic Value[J]. Journal of Kunming Medical University.

Citation:

Lisi LUO, Qingxiong YANG, Yan WANG, Sixiang LIU, Zhen XU, Yu LING. Levels of IGF-1 and IGFBP-3 in Childhood Obesity and Their Diagnostic Value[J]. Journal of Kunming Medical University.

Lisi LUO, Qingxiong YANG, Yan WANG, Sixiang LIU, Zhen XU, Yu LING. Levels of IGF-1 and IGFBP-3 in Childhood Obesity and Their Diagnostic Value[J]. Journal of Kunming Medical University.

Citation:

Lisi LUO, Qingxiong YANG, Yan WANG, Sixiang LIU, Zhen XU, Yu LING. Levels of IGF-1 and IGFBP-3 in Childhood Obesity and Their Diagnostic Value[J]. Journal of Kunming Medical University.

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Levels of IGF-1 and IGFBP-3 in Childhood Obesity and Their Diagnostic Value

1.
Department of Child Healthcare
2.
Department of Radiology
3.
Department of Clinical Laboratory，Kunming Children's Hospital，Kunming Yunnan 650034，China

Received Date: 2024-08-06

Abstract

Abstract

Objective To explore the expression changes of IGF-1 and IGFBP-3 in childhood obesity and their diagnostic value. Methods Blood samples and corresponding clinical information were collected from patients attending Kunming Children's Hospital from December 2023 and March 2024, and were divided into a control group （healthy children; n = 115） and a study group （obese children; n = 86）. Serum levels of IGF-1 and IGFBP-3 in both groups were measured by using ELISA. Clinical data from both groups were analyzed to assess the correlation between IGF-1 and IGFBP-3 and clinical information, as well as their diagnostic value in childhood obesity. Results Compared to the control group, the study group exhibited a significant increase in weight and BMI（P < 0.001） while IGF-1 and IGFBP-3 levels were significantly lower （P < 0.05） . IGF-1 levels exhibited a significant negative correlation with total cholesterol, triglycerides, apolipoprotein B, and insulin resistance index （P < 0.05）, and a significant positive correlation with apolipoprotein A and fasting insulin （P < 0.05）; IGFBP-3 displayed the opposite pattern （P < 0.05）. ROC diagnostic curves indicated that the area under the curve for IGF-1 and IGFBP-3 was 0.598 and 0.665, respectively. Conclusion IGF-1 and IGFBP-3 are expressed at low levels in childhood obesity and are associated with obesity indicators, demonstrating weak diagnostic value.
- Childhood obesity,
- Diagnosis,
- IGF-1,
- IGFBP-3

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References(30)

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