The Relationship Between Serum CTRP7 and CTRP15 Levels and Insulin Resistance and Maternal and Neonatal Outcomes in Patients with Gestational Diabetes Mellitus

Qiang JI; Yuan FANG; Ziping PENG

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Qiang JI, Yuan FANG, Ziping PENG. The Relationship Between Serum CTRP7 and CTRP15 Levels and Insulin Resistance and Maternal and Neonatal Outcomes in Patients with Gestational Diabetes Mellitus[J]. Journal of Kunming Medical University.

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The Relationship Between Serum CTRP7 and CTRP15 Levels and Insulin Resistance and Maternal and Neonatal Outcomes in Patients with Gestational Diabetes Mellitus

1.
Pharmacy Department
2.
Gynaecology and obstetrics Department，Obstetrics and Gynecology Hospital of Tongji University，Shanghai 201204，China

Received Date: 2025-11-20

Abstract

Abstract

Objective To investigate the relationship between serum C1q/tumor necrosis factor-related protein 7 （complement c1q/tnf related proteins7, CTRP7） and CTRP15 levels and insulin resistance （Insulin resistance） as well as maternal and neonatal outcomes in patients with gestational diabetes mellitus. Methods A total of 139 patients diagnosed with gestational diabetes at the Obstetrics and Gynecology Hospital Affiliated to Tongji University from January 2023 to May 2024 were selected as the gestational diabetes group. Based on maternal and neonatal outcomes, they were divided into a GDM with normal outcomes group （91 cases） and a GDM with adverse outcomes group （48 cases）. Additionally, 100 healthy pregnant women who underwent prenatal check-ups during the same period were selected as the healthy pregnant women group. The serum levels of CTRP7 and CTRP15 were measured using the enzyme-linked immunosorbent assay （ELISA） method. Pearson correlation analysis was used to analyze the correlation between serum CTRP7 and CTRP15 levels and insulin resistance, blood glucose, and blood lipids. Logistic regression analysis was used to analyze the factors associated with adverse maternal and neonatal outcomes. Results The GDM group had significantly higher levels of gestational weight gain, placental weight, proportion of chorioamnionitis, HOMA-IR, FBG, TG, TC, LDL-C, FPG, FINS, and HbA1c compared to the healthy pregnant women group, while the proportions of healthy diet and exercise, and HOMA-β were lower than those in the healthy pregnant women group （P < 0.05）. The serum levels of CTRP7 and CTRP15 in the GDM group were significantly higher than those in the healthy pregnant women group（P < 0.05）. Serum CTRP7 and CTRP15 levels were positively correlated with HOMA-IR, FBG, TG, TC, LDL-C, FPG, FINS, and HbA1c （P < 0.05）, and negatively correlated with HOMA-β （P < 0.05）. The GDM with adverse outcomes group had significantly higher levels of gestational weight gain, proportion of chorioamnionitis, HOMA-IR, FBG, TG, TC, LDL-C, FPG, FINS, and HbA1c compared to the GDM with normal outcomes group, while HOMA-β was significantly lower than that in the GDM with normal outcomes group （P<0.05）. Maternal weight gain during pregnancy, chorioamnionitis, HOMA-IR, HOMA-β, FBG, TG, TC, LDL-C, FPG, FINS, HbAlc, CTRP7, and CTRP15 are all influencing factors for adverse maternal and neonatal outcomes in patients with gestational diabetes mellitus （P<0.05）. The combined predictive value of the three is significantly higher than that of each alone （Z=4.265, 3.612, 3.954, P<0.001）. Conclusion Serum levels of CTRP7 and CTRP15 are significantly elevated in patients with gestational diabetes mellitus （GDM） and are closely related to insulin resistance. Combined detection with HOMA-IR has certain predictive value for adverse maternal and infant outcomes.
- Gestational diabetes mellitus,
- CTRP7,
- CTRP15,
- Insulin resistance,
- Maternal and infant outcome

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References(29)

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