The Association Between Serum sCD40L and Myocardial Injury in Acute Myocardial Infarction

Yiying DU; Kecheng WANG; Xin ZHANG; Xilong HU

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Yiying DU, Kecheng WANG, Xin ZHANG, Xilong HU. The Association Between Serum sCD40L and Myocardial Injury in Acute Myocardial Infarction[J]. Journal of Kunming Medical University.

Citation:

Yiying DU, Kecheng WANG, Xin ZHANG, Xilong HU. The Association Between Serum sCD40L and Myocardial Injury in Acute Myocardial Infarction[J]. Journal of Kunming Medical University.

Yiying DU, Kecheng WANG, Xin ZHANG, Xilong HU. The Association Between Serum sCD40L and Myocardial Injury in Acute Myocardial Infarction[J]. Journal of Kunming Medical University.

Citation:

Yiying DU, Kecheng WANG, Xin ZHANG, Xilong HU. The Association Between Serum sCD40L and Myocardial Injury in Acute Myocardial Infarction[J]. Journal of Kunming Medical University.

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The Association Between Serum sCD40L and Myocardial Injury in Acute Myocardial Infarction

Department of Cardiology，3201 Hospital，Hanzhong Shaanxi 723000，China

Received Date: 2025-09-23

Abstract

Abstract

Objective To investigate the association between serum soluble CD40 ligand （sCD40L） levels and myocardial injury in patients with acute myocardial infarction. Methods A total of 126 patients with acute myocardial infarction admitted to the 3201 Hospital between October 2022 and December 2023 were selected as the observation group, while 100 individuals who underwent health examinations during the same period served as the control group. Based on the severity of myocardial injury, the study divided patients into a severe group （47 cases） and a mild group （79 cases）; serum sCD40L levels, cardiac enzyme levels, and cardiac function parameters were compared between the groups; multivariate logistic regression analysis, correlation analysis, and ROC curve analysis were performed to investigate the predictive value of sCD40L for severe myocardial injury. Results The levels of CK-MB, cTnI, CK, H-FABP, and sCD40L in the observation group were higher than those in the control group （P < 0.05）. In the severe group, serum levels of sCD40L, CK-MB, cTnI, CK, H-FABP, LVESD, and LVEDD were higher than those in the mild group, while LVEF levels were lower （P < 0.05）. The results of the multivariate logistic regression analysis indicate that elevated sCD40L, reduced LVEF, elevated CK-MB, and elevated cTnI are independent risk factors for severe myocardial injury. Correlation analysis showed that sCD40L was positively correlated with myocardial injury, LVESD, and LVEDD, and negatively correlated with LVEF （P < 0.001）. The ROC curve indicates that sCD40L has superior predictive value for severe myocardial injury compared to cTnI and CK-MB. Conclusion Serum sCD40L levels are positively correlated with the extent of myocardial injury in acute myocardial infarction; these levels rise as myocardial injury worsens, and the marker demonstrates good predictive value.
- Acute myocardial infarction,
- Myocardial injury,
- Diagnostic value,
- Correlation,
- Cardiac function

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References(25)

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