Changes in Ang-2 Levels Before and after Microwave Ablation Treatment in High-Risk Pulmonary Nodule Patients and Its Impact on Postoperative Recurrence

Yuxiang ZHOU; Guangjun MIAO; Honghong XIAN; Jiangrong LIAO

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Article Navigation > Journal of Kunming Medical University > 2025 > Accepted Manuscript

Yuxiang ZHOU, Guangjun MIAO, Honghong XIAN, Jiangrong LIAO. Changes in Ang-2 Levels Before and after Microwave Ablation Treatment in High-Risk Pulmonary Nodule Patients and Its Impact on Postoperative Recurrence[J]. Journal of Kunming Medical University.

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Changes in Ang-2 Levels Before and after Microwave Ablation Treatment in High-Risk Pulmonary Nodule Patients and Its Impact on Postoperative Recurrence

1.
Department of Respiratory and Critical Care Medicine
2.
Department of Respiratory and Critical Care Medicine，Guizhou Aerospace Hospital，Zunyi Guizhou 563003，China

Received Date: 2025-07-30

Abstract

Abstract

Objective To analyze the changes in angiopoietin-2 （Ang-2） levels before and after microwave ablation （MWA） in patients with high-risk pulmonary nodule and its impact on postoperative recurrence. Method A total of 94 patients with high-risk pulmonary nodules admitted to Guizhou Aerospace Hospital from December 2019 to December 2021 were included and categorized into a recurrence group （n = 30） and a non-recurrence group （n = 64）. Clinical data were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between pre-treatment angiopoietin-2 （Ang-2） levels and CT parameters. Logistic regression model, restricted cubic splines, threshold effect analysis, and receiver operating characteristic （ROC） curve were used to analyze the relationship between pre-treatment Ang-2 levels and postoperative recurrence. Kaplan-Meier survival curves were used to analyze the differences in overall survival among patients with different Ang-2 levels. Cox regression model was used to analyze the factors affecting patients' survival. Result Compared to pre-treatment levels within the same group, Ang-2 levels in both groups decreased significantly, with statistically significant differences （P < 0.05）. Pearson correlation analysis showed that pre-treatment Ang-2 levels were positively correlated with BF, BV, PS, and MTT. Ang-2 level was independently associated with postoperative recurrence. Results of ROC analysis indicated that pre-treatment Ang-2 had certain predictive value for postoperative recurrence （area under the curve=0.789）. Restricted cubic spline analysis revealed a nonlinear dose-response relationship between pre-treatment Ang-2 and postoperative recurrence （P < 0.05）. Threshold effect analysis identified that the inflection point of Ang-2 affecting recurrence as 1905.41 pg/mL. Survival analysis demonstrated that the median overall survival of patients in the Ang-2<1905.41 pg/mL group was longer than that in the Ang-2≥1905.41 pg/mL group （P = 0.039）. Furthermore, Ang-2≥1905.41 pg/mL was an independent factor affecting patients' survival time. Conclusion The levels of Ang-2 decreased significantly in patients with high-risk pulmonary nodules after MWA, and pre-treatment Ang-2 level has certain predictive value for postoperative recurrence.
- High-risk pulmonary nodules,
- Microwave ablation,
- Angiopoietin-2,
- Postoperative recurrence

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References(24)

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