Analysis of the Value of Serum Testosterone，Sex Hormone-Binding Globulin and Vitamin D Levels in Predicting Gestational Diabetes Mellitus Complicated by Polycystic Ovary Syndrome

Yuzhen ZHAO; Yingyan MA; Lili HE

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Yuzhen ZHAO, Yingyan MA, Lili HE. Analysis of the Value of Serum Testosterone，Sex Hormone-Binding Globulin and Vitamin D Levels in Predicting Gestational Diabetes Mellitus Complicated by Polycystic Ovary Syndrome[J]. Journal of Kunming Medical University.

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Analysis of the Value of Serum Testosterone，Sex Hormone-Binding Globulin and Vitamin D Levels in Predicting Gestational Diabetes Mellitus Complicated by Polycystic Ovary Syndrome

Department of Obsterical, Hengshui People’s Hospital，Hengshui Hebei 053000，China

Received Date: 2025-06-02
Available Online: 2025-08-13

Abstract

Abstract

Objective To investigate the value of serum testosterone （T）, sex hormone-binding globulin （SHBG） and vitamin D [25（OH）D] levels in predicting gestational diabetes mellitus （GDM） complicating polycystic ovary syndrome （PCOS）. Methods A retrospective clinical study was conducted on the clinical data from 180 PCOS patients who underwent the standardized treatment and became pregnant and delivered at Hengshui People’ s Hospital between February 2023 and February 2025. Theses patients were categorized into no GDM group （n = 133 cases） and GDM group （n = 47 cases） according to their GDM complication status. The clinical data of the two groups was compared and the binary logistic regression analysis was applied to explore the influencing factors of GDM complicated by PCOS. And ROC curves were established to analyze the serum T, SHBG, 25（OH）D levels and the value efficacy of the three combined data in predicting GDM complicated by PCOS. Results The results of the binary logistic regression model showed that pre-pregnancy BMI, growing body mass during the pregnancy, insulin, T, SHBG, and 25（OH）D were influencing factors of PCOS complicating GDM （P < 0.05）. The ROC curve analysis showed that serum T, SHBG and 25（OH）D levels predicted PCOS-complicated GDM with an AUC of 0.709, 0.825, and 0.718, respectively; sensitivities were 0.915, 0.638, and 0.511, respectively; and specificities were 70.80%, 0.496, 0.940, and 0.902, respectively. The AUC, sensitivity, and specificity of three combined data predictions for PCOS complicated with GDM were 0.929, 0.894, and 0.782, respectively. Pearson correlation showed that serum T, SHBG and 25（OH）D levels were positively correlated with each other in patients with PCOS complicated with GDM （r = 0.559, 0.488, 0.465, P < 0.05）. Conclusion Serum T, SHBG and 25（OH）D levels are valuable in predicting PCOS complicated with GDM, and the combined data of the three items are more effective.
- Polycystic ovary syndrome,
- Gestational diabetes mellitus,
- Testosterone,
- Sex hormone binding globulin,
- Vitamin D,
- Prediction,
- Value

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References(23)

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