Predictive Value of Combined Detection of IL-10，IFN-γ，PLR，and FIB in Endometrial Lesions

Tianyuan ZHAO; Yanhe CHANG; Xiaoyan NI; Yijun WANG; Xiaoyu LIU; Lijie JIANG

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Tianyuan ZHAO, Yanhe CHANG, Xiaoyan NI, Yijun WANG, Xiaoyu LIU, Lijie JIANG. Predictive Value of Combined Detection of IL-10，IFN-γ，PLR，and FIB in Endometrial Lesions[J]. Journal of Kunming Medical University.

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Tianyuan ZHAO, Yanhe CHANG, Xiaoyan NI, Yijun WANG, Xiaoyu LIU, Lijie JIANG. Predictive Value of Combined Detection of IL-10，IFN-γ，PLR，and FIB in Endometrial Lesions[J]. Journal of Kunming Medical University.

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Predictive Value of Combined Detection of IL-10，IFN-γ，PLR，and FIB in Endometrial Lesions

1.
Department of Pathology ，Kailuan General Hospital of Tangshan City，Tangshan Hebei 063000
2.
Department of Laboratory Medicine，Luannan County Hospital，Tangshan City，Tangshan Hebei 063599，China

Received Date: 2025-05-25
Available Online: 2026-04-06

Abstract

Abstract

Objective To analyze the predictive value of combined detection of interleukin-10 （IL-10）, γ-Interferon （IFN - γ）, platelet-to-lymphocyte ratio （PLR）, and plasma fibrinogen（FIB） for endometrial lesions. Method A total of 306 patients with endometrial lesions admitted to the hospital from April 2022 to January 2024 were included in the study. Based on pathological tissue biopsy, patients were divided into endometrial cancer group （n = 120） and endometrial benign hyperplasia group （n = 186）. Sixty-three healthy volunteers from the same period served as control group. The expression levels of IL-10, IFN - γ, PLR, and FIB were measured and compared among the three groups. Receiver operating characteristic （ROC） curve analysis was used to determine the predictive value of IL-10, IFN - γ, PLR, FIB and combined detection for endometrial lesions. Result IL-10, PLR, and FIB levels in the endometrial cancer group were higher than those in the benign endometrial proliferation group and control group, while IFN-γ was lower （P < 0.05）. IL-10, PLR, and FIB levels in the benign proliferation group were higher than control group, while IFN-γ was lower（P < 0.05）. Expression levels of IL-10, IFN-γ, PLR, and FIB showed significant differences among endometrial cancer patients at different International Federation of Gynecology and Obstetrics （FIGO） stages （P < 0.05）. Stage IV endometrial cancer patients had higher IL-10, PLR, and FIB levels and lower IFN-γ levels compared to stages I, II, and III （P < 0.05）. Serous adenocarcinoma had higher IL-10, PLR, and FIB levels and lower IFN-γ levels compared to endometrioid adenocarcinoma （P < 0.05）. Combined detection of IL-10, IFN-γ, PLR, and FIB showed high consistency with pathological diagnosis （Kappa=0.892）. Sensitivity was 94.17% （113/120）, specificity was 94.38% （235/249）, negative predictive value was 97.11% （235/242）, and positive predictive value was 88.98% （113/127）. The area under the ROC curve （AUC） for combined prediction was 0.904 （95%CI: 0.783～0.957）. Conclusion Abnormal expression of IL-10, IFN - γ, PLR, and FIB plays an important role in the occurrence and development of endometrial lesions. Combined detection of these four markers has high predictive value for distinguishing different types of endometrial lesions.
- Interleukin-10,
- Gamma interferon,
- Platelet-to-lymphocyte ratio,
- Fibrinogen,
- Endometrial lesions

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References(30)

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