A Comparative Study of Developmental Trajectories in Term ART and Spontaneously Conceived Infants During Infancy: A Multicenter Investigation Using the Denver Developmental Screening Test

Xiufang LI; Xiaoxia WANG; Tong ZHU; Mengxin LV; Tian HUANG

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Xiufang LI, Xiaoxia WANG, Tong ZHU, Mengxin LV, Tian HUANG. A Comparative Study of Developmental Trajectories in Term ART and Spontaneously Conceived Infants During Infancy: A Multicenter Investigation Using the Denver Developmental Screening Test[J]. Journal of Kunming Medical University.

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A Comparative Study of Developmental Trajectories in Term ART and Spontaneously Conceived Infants During Infancy: A Multicenter Investigation Using the Denver Developmental Screening Test

Xiufang LI¹,
Xiaoxia WANG²,
Tong ZHU³,
Mengxin LV^{4
,
,},
Tian HUANG^{5
,
,}

1.
Department of Pediatrics，Kunming Maternal and Child Health Care Hospital，Kunming Yunnan 650031
2.
Department of Child Healthcare，Dalian Women and Children’s Medical Center，Dalian Liaoning 116037
3.
Department of Ophthalmology，The 920th Hospital of Joint Logistics Support Force of the PLA，Kunming Yunnan 650032
4.
Department of Medical Genetics and Prenatal Diagnosis，Kunming Maternal and Child Health Care Hospital
5.
Department of Child Healthcare，Kunming Maternal and Child Health Care Hospital，Kunming Yunnan 650031，China

Received Date: 2024-11-01
Available Online: 2026-04-26

Abstract

Abstract

Objective To investigate the developmental differences between full-term infants born through assisted reproductive technology （ART） and infants conceived naturally at 6 and 12 months of age, in order to provide scientific evidence for the healthy development of infants' cognitive abilities due to assisted reproductive technology. Methods A nested case-control study was conducted to compare the developmental status of infants conceived through ART and those conceived naturally who visited the Women and Children's Medical Center of Dalian and Kunming Maternal and Child Health Hospital from October 2023 to April 2024. The basic demographic characteristics such as gender, gestational age at birth, weight, height, and head circumference, as well as the developmental screening results of both groups were compared. The Denver Developmental Content Record was used for assessment, and a comprehensive evaluation was conducted based on the Denver Developmental Screening Test （DDST）. Results There was no statistically significant difference in basic characteristics between the two groups （P > 0.05）. There was no statistically significant difference in fine motor skills, gross motor skills, language, and social development assessments at 6 months and 12 months （P > 0.05）. Statistical analysis using SPSS 20.0 showed that the overall comparison of DDST indicated that the early developmental levels of the two groups were similar （P = 0.957 and P = 0.965）. Conclusions By comparing the development of fine motor skills, gross motor skills, social development and language development in DDST, it was found that there were no significant statistical differences in the results among different conception methods.
- Assisted reproduction,
- Term infants,
- Denver development

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References(32)

References

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