A Study on the Related Factors of Atrial Fibrillation in Patients with Type 2 Diabetes

Wanshu LIU; Furong DENG; Ping YANG; Xin TIAN; Guangli ZHOU; Lingmin ZHAO; Xueting ZHANG; Keyi ZHANG

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 >

Wanshu LIU, Furong DENG, Ping YANG, Xin TIAN, Guangli ZHOU, Lingmin ZHAO, Xueting ZHANG, Keyi ZHANG. A Study on the Related Factors of Atrial Fibrillation in Patients with Type 2 Diabetes[J]. Journal of Kunming Medical University.

Citation:

PDF( 585 KB)

A Study on the Related Factors of Atrial Fibrillation in Patients with Type 2 Diabetes

Dept. of Cardiology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2023-12-28
Available Online: 2024-11-23

Abstract

Abstract

Objective To investigate the factors associated with atrial fibrillation（AF） in patients with Type 2 Diabetes Mellitus （T2DM）. Methods Through a case-control study, We selected 688 patients with T2DM who were hospitalized at the First Affiliated Hospital of Kunming Medical University from January 2015 to November 2021. Based on the AF diagnostic criteria, all the patients were divided into a case group （AF group） of 368 cases and a control group （non-AF group） of 320 cases. All patients' clinical data were collected and used Stata 15.1 statistical software were used for analyze the relevant influencing factors of AF in patients with T2DM. Results Age, duration of DM, glycated hemoglobin level, body mass index, left atrial diameter, creatinine, C2HEST score, and heart failure might be risk factors for AF in T2DM patients（P < 0.05）; among them, age, glycated hemoglobin level, left atrial diameter, C2HEST score might be independent risk factors for AF in T2DM patients; the use of sodium-glucose co-transporter 2 inhibitors （Sodium/Glucose Co-transporter 2 Inhibitor, SGLT2i） andβ-blockers （P < 0.05） might be its protective factors. Conclusion Old age, high HbA1c level, increased left atrial diameter, and high C2HEST score maight be independent risk factors for atrial fibrillation in T2DM patients. The use of SGLT2i and β-blockers in T2DM patients may have a protective effect on the occurrence of atrial fibrillation.
- Type 2 diabetes mellitus,
- Atrial fibrillation,
- Glycosylated hemoglobin A1c,
- Sodium/Glucose Co-transporter 2 Inhibitor

FullText(HTML)

References(18)

References

[1]	Cosentino F,Grant P J,Aboyans V,et al. 2019 ESC Guidelines on diabetes,pre-diabetes,and cardiovascular diseases developed in collaboration with the EASD[J]. Eur Heart J,2020,41(2):255-323. doi: 10.1093/eurheartj/ehz486
[2]	Benjamin E J,Muntner P,Alonso A,et al. Heart disease and stroke statistics-2019 update: a report from the American Heart Association[J]. Circulation,2019,139(10):e56-e528.
[3]	Karayiannides S,Lundman P,Friberg L,et al. High overall cardiovascular risk and mortality in patients with atrial fibrillation and diabetes: A nationwide report[J]. Diab Vasc Dis Res,2018,15(1):31-38. doi: 10.1177/1479164117735013
[4]	Wang A,Green J B,Halperin J L,et al. Atrial fibrillation and diabetes mellitus: JACC review topic of the week[J]. J Am Coll Cardiol,2019,74(8):1107-1115. doi: 10.1016/j.jacc.2019.07.020
[5]	Fangel M V,Nielsen P B,Kristensen J K,et al. Glycemic status and thromboembolic risk in patients with atrial fibrillation and type 2diabetes mellitus: A Danish cohort study[J]. Circ Arrhythm Electrophysiol,2019,12(5):e007030.
[6]	Dahlqvist S,Rosengren A,Gudbjörnsdottir S ,et al. Risk of atrial fibrillation in people with type 1 diabetes compared with matched controls from the general population: A prospective case-control study[J]. Lancet Diabetes Endocrinol,2017,5(10): 799-807.
[7]	Pallisgaard J L,Schjerning A M,Lindhardt T B,et al. Risk of atrial fibrillation in diabetes mellitus: a nationwide cohort study[J]. Eur J Prev Cardiol,2016,23(6):621-627. doi: 10.1177/2047487315599892
[8]	王擎, 王建礼, 王海英, 等. 糖尿病对心房颤动的作用[J]. 国际心血管病杂志,2020,47(1):40-43.
[9]	Allan V,Honarbakhsh S,Casas J P,et al. Are cardiovascular risk factors also associated with the incidence of atrial fibrillation? A systematic review and field synopsis of 23 factors in 32 52 populationbased cohorts of 20 million participants[J]. Thromb Haemost,2017,117(5):837-850.
[10]	邱娜,凌宏威,周冬梅,等. 2型糖尿病合并心房颤动的危险因素分析[J]. 中国医药导报,2019,16(11):105-108.
[11]	American Diabetes Association. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2021[J]. Diabetes Care,2021,44(Suppl 1):S15-S33.
[12]	Hindricks G, Potpara T,Dagres N,et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC[J]. Eur Heart J,2021,42(5):373-498. doi: 10.1093/eurheartj/ehaa612
[13]	郭倩. 血清羧甲基赖氨酸及半乳糖凝集素3与2型糖尿病合并房颤的相关性研究[D]. 大连医科大学, 2023: 1-51.
[14]	American Diabetes Association. 6. Glycemic Targets: Standards of Medical Care in Diabetes-2021[J]. Diabetes Care.,2021,44(Suppl 1):S73-S84.
[15]	冯玉英. 糖化血红蛋白和超敏C反应蛋白在预测2型糖尿病患者心房颤动中的价值研究[J]. 糖尿病新世界,2019,22(4):47-48.
[16]	Radholm K, Wu JH, Wong MG, et al. Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular disease, death and safety outcomes in type 2 diabetes-A systematic review[J]. Diabetes Res Clin Pract,2018,140:118-128.
[17]	马鸣飞,刘燕,李小燕,等. 达格列净对糖尿病合并心衰患者左心功能和新发房颤风险的影响[J]. 中国医刊,2024,59(4):429-432. doi: 10.3969/j.issn.1008-1070.2024.04.016
[18]	朱卓越. 达格列净对合并2型糖尿病及阵发性心房颤动的慢性心力衰竭患者的疗效研究[D]. 河北医科大学, 2023: 1-40.

Relative Articles(20)

Relative Articles

[1]	Man YANG, Xingan ZHAO, Yunna GE, Juan QIN, Xiya WANG, Siming TAO. Identification of Atrial Fibrillation-related Inflammatory Genes and Their Association with Immune Cell Infiltration Based on Comprehensive Bioinformatic Analysis. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240303
[2]	Yu CHANG, Li GUI, Ruonan LI. Observation of Liraglutide's Effect on Function of Pancreatic Islets β-Cell in Type 2 Diabetes. Journal of Kunming Medical University,
[3]	Zilin MA, Wenni MA, Yi MA, Yongshi FAN, Yan JIN, Ying HUANG. Investigation and Analysis of Health Education Needs of Patients Undergoing Radiofrequency Ablation of Atrial Fibrillation Based on Kano Model. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240225
[4]	Longqiao TAN, Li SHI, Jianfang LIU, Xuemei XIA, Li ZHU, Yushan XU. Correlation between 24-hour Urinary Sodium Excretion，IL-18 Level and Urinary Albumin in Patients with Type 2 Diabetes Mellitus. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240908
[5]	Xinlin ZHU, Yanan WU, Qi MENG, Qianzi YANG, Yuanbiao LI, Junheng TAO, Mengyang HE. Influence of Medication Compliance of Type 2 Diabetes Chronic Disease Management Patients in Two Communities of Kunming on Disease Control. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20240312
[6]	Yanbo YUAN, Zhaojuan RUAN, Liangju CAO, Wanjuan YANG, Yu JIANG, Xue ZHOU. Content Analysis of Concentrated Growth Factor Fibrin Gel in Patients with Type 2 Diabetes Mellitus. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20230720
[7]	Er-shu RUAN, Shuo WANG, Hui SU, Feng-qiong YIN, Zhong-yi QIAN, Jian-yu YANG. Effect of Ginsenoside Rg1 on Renal Protection in Type 2 Diabetic Rats. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210625
[8]	Hao LI, Jing WANG, Ping YANG. Research Progress of Atrial Fibrillation and Atrial Metabolic Remodeling. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210335
[9]	Qiong ZHOU, Bao-kun PENG, Xiao-chun WENG, Zhen JU, Nuo-pi-chu SUN, Zhe TANG. Clinical Characteristics of Newly Diagnosed Type 2 Diabetes Mellitus and Influencing Factors of Glycosylated Hemoglobin Among Tibetans in Deqin. Journal of Kunming Medical University, doi: 10.12259/j.issn.2095-610X.S20210819
[10]	Su Xiao Yang , Zhao Yu Mei , Nian Xin , Song Dian Ping . . Journal of Kunming Medical University,
[11]	Zhu Jia Ni , Zhang Lun , Yang Fan , Zhang Zhen Yu , Gu Ran , Liu Ji , Hong Jing An . . Journal of Kunming Medical University,
[12]	Han Wen Ju , Niu Ben , Liang Yun, Duan Xiao Yan , Su Heng , Xue Yuan Ming . The Relationship between Thyroid Hormone and Purine Metabolism and Body Weight in Patients with Type II Diabetes and Normal Thyroid Function. Journal of Kunming Medical University,
[13]	Nian Xin . Difference of Metallothionein Gene G-201A Polymorphism in Type 2 Diabetes and Essential Hypertension. Journal of Kunming Medical University,
[14]	Xiang Xi . . Journal of Kunming Medical University,
[15]	Wang Xiang Yun . . Journal of Kunming Medical University,
[16]	Du Juan . . Journal of Kunming Medical University,
[17]	Zhang Liang Zheng . . Journal of Kunming Medical University,
[18]	Wang Cun De . . Journal of Kunming Medical University,
[19]	Li Xian Li . . Journal of Kunming Medical University,
[20]	. The Relationship between Glycated Hemoglobin and Diabetic Retinopathy. Journal of Kunming Medical University,