The Prognostic Value of Uterine Artery Blood Flow Combined with Serum Factors for Preeclampsia in Mid-pregnancy

Ruiyan LEI; Huimin HAO; Peiying WANG; Hui SUN; Li ZHANG

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Ruiyan LEI, Huimin HAO, Peiying WANG, Hui SUN, Li ZHANG. The Prognostic Value of Uterine Artery Blood Flow Combined with Serum Factors for Preeclampsia in Mid-pregnancy[J]. Journal of Kunming Medical University.

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Ruiyan LEI, Huimin HAO, Peiying WANG, Hui SUN, Li ZHANG. The Prognostic Value of Uterine Artery Blood Flow Combined with Serum Factors for Preeclampsia in Mid-pregnancy[J]. Journal of Kunming Medical University.

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The Prognostic Value of Uterine Artery Blood Flow Combined with Serum Factors for Preeclampsia in Mid-pregnancy

1.
Medical Ultrasound Center，Northwest Women's and Children's Hospital，Xi'an Shaanxi 710061
2.
Department of Ultrasound Medical（Jiangtan），Baoji Central Hospital，Baoji Central Hospital，Baoji Shaanxi 721006
3.
Department of Children’s Rehabilitation，Peking University First Hospital Ningxia Women and Children's Hospital，Yinchuan Ningxia 750001，China

Received Date: 2025-06-19

Abstract

Abstract

Objective To explore the value of uterine artery blood flow Doppler ultrasound combined with serum suppressor of cytokine signaling 3 （SOCS-3） and Fibulin-3 in predicting the pregnancy outcome of preeclampsia pregnant women in the second trimester Method A retrospective analysis method was adopted. The clinical baseline data of 123 pregnant women with preeclampsia in the second trimester who were received by the Medical Ultrasound Center of Northwest Women's and Children's Hospital from January 2022 to December 2024 were collected as the case group. Another 105 pregnant women in the second trimester who underwent routine health examinations were selected as the normal group. The uterine artery blood flow parameters were detected by color Doppler ultrasound. Including the pulsatility index （PI） and the resistance index RI and the ratio of systolic peak velocity to end-diastolic velocity （S/D）; The levels of serum SOCS-3 and Fibulin-3 were detected by enzyme-linked immunosorbent assay （ELISA）. the predictive efficacy of individual and combined detection of each index for the pregnancy outcome of preeclampsia was evaluated through statistical analysis, and the area under the curve （AUC）, sensitivity and specificity were calculated. Result The PI, RI, S/D values of uterine artery blood flow and the level of Fibulin-3 in the case group of pregnant women were all higher than those in the normal group, while the level of serum SOCS-3 was significantly lower than that in the normal group （P < 0.05）. Among pregnant women with preeclampsia in the second trimester of pregnancy, there were 3 cases of premature birth, 5 cases of fetal growth restriction, 10 cases of placental abruption, 7 cases of eclampsia, 10 cases of postpartum hemorrhage, and a total of 35 cases of adverse pregnancy outcomes. Univariate analysis showed that PI, RI, S/D values and serum levels of SOCS-3 and Fibulin-3 were all influencing factors of adverse pregnancy outcomes （P < 0.05）; Logistic regression analysis confirmed that Fibulin-3, RI, S/D value, decreased SOCS-3, and elevated PI were independent risk factors for adverse pregnancy outcomes （P < 0.05）. Construct a joint prediction model （regression equation:）（Fibulin-3×4.767+RI×1.735+S/D value ×2.286-SOCS-3×10.402+PI×1.044）, the area under the ROC curve （AUC） was 0.998, the specificity was 96.59%, and the sensitivity was 100.00% It was significantly superior to each individual indicator （Fibulin-3 AUC 0.996, RI AUC 0.977, S/D value AUC 0.877, SOCS-3 AUC 0.914, PI AUC 0.794, P < 0.05）. Conclusion The combination of uterine artery blood flow parameters and the levels of SOCS-3 and Fibulin-3 in serum has a predictive value that significantly exceeds the limitations of a single indicator, greatly improving the accuracy of predicting adverse pregnancy outcomes in pregnant women with preeclampsia. It provides a new evaluation method for the early prediction of pregnancy outcomes in pregnant women with preeclampsia in the second trimester.
- Preeclampsia,
- Pregnancy outcome,
- Doppler ultrasound of uterine artery blood flow,
- cytokine signal inhibitor 3,
- Fibulin-3,
- Predictive value

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