Synergistic Mechanisms and Applications of Phage-Antibiotic Combination Therapy

Xuelin LI; Xiaoyan YANG; Zehua HAN; Yuliang CHEN; Xingyuan XU; Chunyan ZHANG; Yingying XIANG

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Xuelin LI, Xiaoyan YANG, Zehua HAN, Yuliang CHEN, Xingyuan XU, Chunyan ZHANG, Yingying XIANG. Synergistic Mechanisms and Applications of Phage-Antibiotic Combination Therapy[J]. Journal of Kunming Medical University.

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Synergistic Mechanisms and Applications of Phage-Antibiotic Combination Therapy

1.
Department of Stomatology
2.
Department of Dermatology ，Yan’an Hospital Affiliated to Kunming Medical University，Kunming Yunnan 650031
3.
Department of Stomatology，Xundian Hui and Yi Autonomous County People’s Hospital，Kunming Yunnan 655200，China

Abstract

Abstract

The overuse of antibiotics has led to a rapid increase of antibiotic-resistant bacteria, making bacterial infections difficult to control effectively and posing a serious threat to human health. As antibiotic resistance problems become increasingly severe and the development of new antibiotics lags, finding more effective treatment strategies has become an urgent need in global public health. Bacteriophages, as a potential therapeutic option, have attracted increasing attention in recent years; however, bacteriophages have limitations such as a narrow host range and lysogeny. Synergistic effects between bacteriophages and antibiotics enhance bacteriophage lytic activity, reduce antibiotic dosage, significantly lower the risk of resistance development, and demonstrate superior antimicrobial efficacy. This review summarizes the mechanisms and research progress of bacteriophage-antibiotic synergy, aiming to further advance research and clinical application of combined bacteriophage-antibiotic therapy and provide new solutions to address the problem of antibiotic resistance.
- Bacteriophage,
- Antibiotic,
- Combination therapy,
- Resistance,
- Synergistic effects

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References(44)

References

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