Effect of Tirofiban on Serum miR-181c and miR-130a Expression in Patients with Acute Ischemic Stroke Following Failed Thrombolysis in the Hyperacute Phase

Jian SUN; Huanhuan WANG; Hongmei HE; Haiyan ZHANG; Qian XUE; Aixia SONG

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Jian SUN, Huanhuan WANG, Hongmei HE, Haiyan ZHANG, Qian XUE, Aixia SONG. Effect of Tirofiban on Serum miR-181c and miR-130a Expression in Patients with Acute Ischemic Stroke Following Failed Thrombolysis in the Hyperacute Phase[J]. Journal of Kunming Medical University.

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Effect of Tirofiban on Serum miR-181c and miR-130a Expression in Patients with Acute Ischemic Stroke Following Failed Thrombolysis in the Hyperacute Phase

Department of Neurology，The First Affiliated Hospital of Hebei North University，Zhangjiakou Hebei 075000，China

Received Date: 2025-09-03
Available Online: 2026-03-29

Abstract

Abstract

Objective To analyze the effects of tirofiban on serum microRNA-181c （miR-181c） and microRNA-130a （miR-130a） expression in patients with hyperacute cerebral infarction after thrombolytic failure. Methods A total of 85 patients with hyperacute cerebral infarction who failed thrombolysis and were hospitalized at the First Affiliated Hospital of Hebei North University from November 2022 to November 2024 were enrolled. The research subjects were grouped according to the treatment regimen: the control group （n = 42） received conventional treatment, and the observation group （n = 43） received tirofiban treatment in addition to conventional therapy. Statistical comparisons were conducted on the total effective rate, infarct volume, cerebral perfusion parameters, vascular recanalization rate, National Institutes of Health Stroke Scale （NIHSS） score, Barthel Index （BI） score, coagulation function indices, serum miR-181c, miR-130a levels, and occurrences of hemorrhagic events. Results The observation group demonstrated significantly higher total effective rate and vascular recanalization rate compared to the control group （P < 0.05）. After treatment, the observation group showed significantly lower infarction volume, time to peak （TTP）, mean transit time （MTT）, NIHSS score, platelet count （PLT）, fibrinogen （FIB）, and serum miR-181c and miR-130a levels compared to the control group （P < 0.05）. The observation group exhibited significantly higher cerebral blood flow （CBF）, cerebral blood volume （CBV）, BI score, and prothrombin time （PT） compared to the control group （P < 0.05）. There was no significant difference in the overall incidence of hemorrhagic events between the two groups （P > 0.05）. Conclusion Rescue treatment with tirofiban after thrombolytic failure in hyperacute cerebral infarction effectively reduces the degree of neurological impairment, decreases infarct volume, improves vascular recanalization rate and functional capacity, corrects hypercoagulability, improves cerebral perfusion parameters, and reduces serum miR-181c and miR-130a expression levels and the incidence of hemorrhagic adverse events, proving to be safe and effective.
- Hyperacute cerebral infarction,
- Tirofiban,
- microRNA-181c,
- microRNA-130a

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References(22)

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