Analysis of Risk Factors and Gene Type Distribution of High Risk HPV Infection in 12688 Women Aged 18-60

Lan LAN; Xuan XIAO

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Lan LAN, Xuan XIAO. Analysis of Risk Factors and Gene Type Distribution of High Risk HPV Infection in 12688 Women Aged 18-60[J]. Journal of Kunming Medical University.

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Lan LAN, Xuan XIAO. Analysis of Risk Factors and Gene Type Distribution of High Risk HPV Infection in 12688 Women Aged 18-60[J]. Journal of Kunming Medical University.

Lan LAN, Xuan XIAO. Analysis of Risk Factors and Gene Type Distribution of High Risk HPV Infection in 12688 Women Aged 18-60[J]. Journal of Kunming Medical University.

Citation:

Lan LAN, Xuan XIAO. Analysis of Risk Factors and Gene Type Distribution of High Risk HPV Infection in 12688 Women Aged 18-60[J]. Journal of Kunming Medical University.

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Analysis of Risk Factors and Gene Type Distribution of High Risk HPV Infection in 12688 Women Aged 18-60

Lan LAN¹,
Xuan XIAO^{2
,
,}

1.
Department of Gynecology，Liaoning Cancer Hospital，Shenyang Liaoning 110042
2.
Department of General Surgery，Liaoning People’s Hospital，Shenyang Liaoning 110016，China

Received Date: 2025-05-27
Available Online: 2025-08-21

Abstract

Abstract

Objective To discuss the risk factors and genotype distribution of high-risk human papillomavirus （HR-HPV） infection in women aged 18～60 in Liaoning region. Methods A total of 12688 women aged 18~60 from Liaoning Province from June to December 2024 were selected as the research subjects. Logistic regression analysis was used to screen risk factors for HR-HPV infection in women aged 18～60 in the Liaoning region, and the distribution of gene types was statistically analyzed. Results Among 12688 women aged 18～60 in Liaoning region, 2992 （23.58%） were infected with HR-HPV. Among the 2992 with HR-HPV infection, 2804 were infected with single infection and 188 with mixed infection. Among the 2804 single infected individuals, the main genetic types were HPV 16, HPV 52, and HPV 58 respectively. The results of logistic regression analysis showed that divorce or widowhood （OR = 3.005, P = 0.001）, age of first sexual intercourse younger than 18 years old （OR = 2.111, P = 0.002）, number of abortions more than 2 times （OR = 1.703, P = 0.000）, lack of previous HPV vaccination （OR = 4.852, P = 0.000）, smoking history （OR = 3.169, P = 0.000）, cervical and vaginal inflammation （OR = 4.741, P = 0.002）, and syphilis infection （OR = 3.726, P = 0.000） were independent risk factors for HR-HPV infection in women aged 18～60 in Liaoning region. Conclusion The independent risk factors for HR-HPV infection in women aged 18～60 in Liaoning region include divorce or widowhood, age of first sexual intercourse younger than 18 years old, number of abortions more than 2 times, lack of previous HPV vaccination, smoking history, cervical and vaginal inflammation, syphilis infection, and the main genetic types are HPV 16, HPV 52, and HPV 58.
- Women,
- High-risk human papillomavirus,
- Risk factors,
- Genotype

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References(34)

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