Impact of Minimally Invasive Extracorporeal Circulation on Systemic Inflammatory Response and Transfusion Requirements after Coronary Artery Bypass Grafting

Xiaojuan ZHOU; Libin YANG; Peng YANG; Hao GONG; Xu YANG

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Xiaojuan ZHOU, Libin YANG, Peng YANG, Hao GONG, Xu YANG. Impact of Minimally Invasive Extracorporeal Circulation on Systemic Inflammatory Response and Transfusion Requirements after Coronary Artery Bypass Grafting[J]. Journal of Kunming Medical University.

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Impact of Minimally Invasive Extracorporeal Circulation on Systemic Inflammatory Response and Transfusion Requirements after Coronary Artery Bypass Grafting

Department of Cardiovascular Surgery，Affiliated Hospital of Yunnan University，Kunming Yunnan 650021，China

Received Date: 2024-09-17
Available Online: 2025-02-23

Abstract

Abstract

Objective This study aims to explore the effects of Minimally Invasive Extracorporeal Circulation （MECC） on systemic inflammatory response and transfusion requirements following Coronary Artery Bypass Grafting （CABG）. Methods A total of 126 patients who underwent CABG from January 2023 to January 2024 were selected and randomly divided into an observation group and a control group, with 63 patients in each group. The observation group received MECC, while the control group was treated with Conventional Extracorporeal Circulation （CECC）. Inflammatory response indicators, immune system function, coagulation function, renal function, cardiac function, and clinical symptoms were monitored preoperatively and at 24, 48, and 72 hours postoperatively for comparison and analysis. Results At 24 hours postoperatively, CRP, IL-6 and TNF-α levels in the observation group were （18.5±3.7） mg/L, （15.2±3.4） pg/mL and （25.3±5.6） pg/mL, respectively, which were significantly lower than those in the control group（P < 0.05）. At 48 hours postoperatively, the CD4+/CD8+ ratio in the observation group was 1.6±0.3, which was higher than that in the control group （P < 0.05）. At 72 hours postoperatively, the PT and APTT in the observation group were （12.1±1.2） seconds and （30.4±3.2） seconds, respectively, which were significantly lower than those in the control group （P < 0.05）. Additionally, 72 hours after surgery, SCr and BUN in the observation group were （1.1±0.2） mg/dL and 14.6±3.1 mg/dL, respectively, which were significantly lower than those in the control group （P < 0.05）. In terms of cardiac function indexes, at 24 hours postoperatively, CI, LVEF, cTnI and BNP in the observation group were （2.6±0.5） L/min/m², （55.6±4.0）%, （0.14±0.03） ng/mL, and （280±30） pg/mL, respectively, which were significantly better than those in the control group（P < 0.05）. At all postoperative time points, the VAS score, complication rate, length of hospital stay and ICU stay were significantly better in the observation group than in the control group （P < 0.05）, with the VAS score at 24 hours postoperatively being （4.8±1.2） compared to （5.5±1.3） in the control group（P < 0.05）. Conclusions MECC demonstrates significant advantages in attenuating systemic inflammatory response after CABG, protecting multi-system function, reducing postoperative blood transfusion requirements, and improving postoperative recovery. Compared with traditional extracorporeal circulation, MECC effectively reduce postoperative inflammatory reactions and complications, enhancing the quality of life for patients post-surgery, and shows broad clinical application prospects.
- Minimally invasive extracorporeal circulation,
- Coronary artery bypass grafting,
- Inflammatory response,
- Transfusion requirements

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