Analysis of HPV Positivity Rates and High-Risk Genotypes among Multi-Ethnic Women Aged 35-64 in Lijiang City，Yunnan Province

Junqiang WANG; Limei ZHAO; Ping HE; Jinkun XIONG; limei HE; Kaixiang QIAN

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Junqiang WANG, Limei ZHAO, Ping HE, Jinkun XIONG, limei HE, Kaixiang QIAN. Analysis of HPV Positivity Rates and High-Risk Genotypes among Multi-Ethnic Women Aged 35-64 in Lijiang City，Yunnan Province[J]. Journal of Kunming Medical University.

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Analysis of HPV Positivity Rates and High-Risk Genotypes among Multi-Ethnic Women Aged 35-64 in Lijiang City，Yunnan Province

Junqiang WANG^{1, 2},
Limei ZHAO³,
Ping HE²,
Jinkun XIONG⁴,
limei HE^{1
,
,},
Kaixiang QIAN^{4
,
,}

1.
School of Public Health，Kunming Medical University/Yunnan Key Laboratory of Cross-border Infectious Disease Prevention and Control and New Drug Development，Kunming Yunnan 650500
2.
Department of Obstetrics and Gynecology ，Lijiang Maternal and Child Health Care Hospital，Lijiang Yunnan 674100
3.
Maternal and Child Health Care Department，Lijiang Municipal Health Commission，Lijiang Yunnan 674100
4.
Health Care Department，Lijiang Maternal and Child Health Hospital，Lijiang Yunnan 674100，China

Received Date: 2026-06-01
Available Online: 2026-10-16

Abstract

Abstract

Objective To analyze the human papillomavirus （HPV） infection rate and high-risk genotype distribution among women aged 35–64 in the Lijiang region, and to explore the association between various sociodemographic factors and HPV infection. Methods A cross-sectional study was conducted based on data from the "Two Cancers Screening" program in Lijiang City from January 2024 to December 2025. Eligible women aged 35–64 who completed HPV testing were selected as study participants. Chi-square tests was used to compare HPV positivity rates across different population groups, and a multivariate logistic regression model was used to analyze factors associated with HPV infection. Results A total of 99, 981 women were included, with an average age of （48.57±7.87） years. The HPV positivity rate was 9.25% （95%CI: 9.07%～9.43%）, and the positive rate for HPV16/18 types was 1.60%. Fourteen high-risk HPV genotypes were detected, among which HPV16 had the highest positivity rate （1.17%）, followed by HPV52 （0.52%）, HPV18 （0.46%）, and HPV58 （0.30%）. Statistically significant differences in HPV positivity rates were observed across age groups （χ² = 12.975）, ethnic groups （χ² = 80.695）, educational levels （χ² = 70.147）, counties/districts （χ² = 146.518）, and medical institutions （χ² = 139.640）（all P < 0.05）. Women aged 55–64 had a higher HPV positivity rate （9.56%）, and Yi women had the highest positivity rate （10.97%）. Multivariate logistic regression analysis showed that, compared with the 35～44 age group, women aged 45～54 had a reduced risk of HPV infection （OR = 0.904, 95%CI: 0.859～0.952）. Compared with women with primary school education or below, those with junior high school （OR = 0.902, 95%CI: 0.854～0.953）, senior high school/secondary vocational education （OR = 0.883, 95% CI: 0.804～0.968）, and junior college education or above （OR = 0.688, 95%CI: 0.624～0.758） had significantly lower infection risks. Compared with Han women, Yi women had a significantly higher risk of HPV infection （OR = 1.137, 95%CI: 1.060～1.218）, whereas women of the Pumi （OR = 0.761, 95%CI: 0.620～0.924）, Naxi （OR = 0.859, 95%CI: 0.795～0.927）, Lisu （OR = 0.847, 95%CI: 0.776～0.922）, and Bai （OR = 0.875, 95%CI: 0.776～0.984） ethnic groups had significantly lower infection risks. Conclusion The HPV positivity rate among women aged 35～64 in the Lijiang region is generally consistent with previous findings in southwestern China, with HPV types 16, 52, 18, and 58 as the predominant subtypes. Older women, Yi women, and women with lower educational attainment have relatively higher infection risks.
- High-risk human papillomavirus,
- Cervical cancer,
- Genotype,
- Multi-ethnic

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References(40)

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