The Clinical Screening Value of Peripheral Blood NETs Combined with Salivary Gland Ultrasound Score for Primary Sjögren's Syndrome

Miaomiao DING; Hongling LIU; Hong WEI

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Miaomiao DING, Hongling LIU, Hong WEI. The Clinical Screening Value of Peripheral Blood NETs Combined with Salivary Gland Ultrasound Score for Primary Sjögren's Syndrome[J]. Journal of Kunming Medical University.

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The Clinical Screening Value of Peripheral Blood NETs Combined with Salivary Gland Ultrasound Score for Primary Sjögren's Syndrome

1.
Department of Blood Transfusion，Affiliated Hospital of Shandong Second Medical University，Weifang Shandong 262100
2.
Department of Blood Transfusion，Anqiu People's Hospital，Weifang Shandong 262100
3.
Laboratory Department，Weifang Hospital of Traditional Chinese Medicine，Weifang Shandong 262100，China

Received Date: 2025-12-27

Abstract

Abstract

Objective To analyze the screening value of markers of neutrophil extracellular traps （NETs） in peripheral blood combined with ultrasound scoring for primary Sjogren's syndrome （pSS）. Method From June 2024 to December 2025, 60 patients with primary Sjögren's syndrome （pSS） were selected as the pSS group, while 60 patients with systemic lupus erythematosus （SLE） during the same period were selected as the disease control group, and 60 healthy individuals undergoing physical examinations were selected as the healthy control group. The peripheral blood NETs markers [myeloperoxidase-DNA （MPO-DNA）, citrullinated histone 3 （CitH3）] and ultrasound were compared among the three groups. Results The levels of MPO-DNA and CitH3 in peripheral blood of the pSS group and the disease control group were higher than those in the healthy control group （P < 0.05）; the ultrasound scores of parotid and submandibular glands in the pSS group were higher than those in the disease control group and the healthy control group （P < 0.05）. The blood flow signals in the pSS group were mainly at grade II. The peripheral blood MPO-DNA, CitH3, and ultrasound scores of parotid and submandibular glands in the high disease activity group were higher than those in the moderate and low disease activity groups （P < 0.05）. The area under the curve （AUC） of the combined detection of MPO-DNA, CitH3, parotid and submandibular gland ultrasound scores for screening pSS was higher than that of single detection （P < 0.05）. Conclusion Joint detection of peripheral blood MPO-DNA, CitH3, and ultrasound scores of parotid gland and submandibular gland can enhance the screening value for pSS.
- Neutrophil extracellular traps,
- Ultrasound score,
- Primary Sjgren's syndrome,
- Risk factors

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References(20)

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