Relationship Between Latent Class of Frailty and Symptom Distress in Lung Cancer Radiotherapy Patients

Jiang WU; Xijuan ZHAO; Shoutao YANG; Yanyan FEI; Liping ZHOU; Jiang ZHANG

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Article Navigation > Journal of Kunming Medical University > 2025 > Accepted Manuscript

Jiang WU, Xijuan ZHAO, Shoutao YANG, Yanyan FEI, Liping ZHOU, Jiang ZHANG. Relationship Between Latent Class of Frailty and Symptom Distress in Lung Cancer Radiotherapy Patients[J]. Journal of Kunming Medical University.

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Relationship Between Latent Class of Frailty and Symptom Distress in Lung Cancer Radiotherapy Patients

1.
Department of Radiation Oncology，The Third Affiliated Hospital of Kunming Medical University，Yunnan Cancer Hospital，Peking University Cancer Hospital Yunnan ，Kunming Yunnan 650118
2.
Department of Oncology ，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101
3.
Department of Trade union，The Third Affiliated Hospital of Kunming Medical University，Yunnan Cancer Hospital，Peking University Cancer Hospital Yunnan，Kunming Yunnan 650118，China

Received Date: 2024-12-09

Abstract

Abstract

Objective To analyze potential latent class of frailty and influencing factors in lung cancer radiotherapy patients, and to explore the relationship between different frailty categories and symptom distress. Methods A convenience sampling method was used to recruit 241 lung cancer radiotherapy patients admitted to the Radiotherapy Department of a tertiary Grade-A oncology hospital in Yunnan Province from April to December 2023. Data were collected using questionnaires including: general demographic survey of lung cancer radiotherapy patients, frailty phenotype scale, Anderson Symptom Assessment Scale, and Nutritional Risk Screening 2002. Latent class analysis was employed to identify heterogeneity of frailty among different populations of lung cancer radiotherapy patients. Multinomial logistic regression analysis was used to explore factors influencing the internal heterogeneity of frailty. Generalized linear modeling was applied to analyze the impact of different frailty classes on patients' symptom burden. Results Results: Frailty in lung cancer radiotherapy patients presented three latent classes: pre-frailty group （30.29%）, frailty with unintentional weight loss group （35.68%）, and severe frailty with decreased physical activity group （34.02%）. Radiotherapy frequency （P < 0.05）, age （P < 0.05）, and nutritional risk score （P < 0.05） were identified as influencing factors for latent classes of frailty. Latent frailty classes were significant predictors of symptom burden scores （P < 0.001）. Conclusion Frailty in lung cancer radiotherapy patients demonstrates population heterogeneity, with varying influencing factors across different classes. Latent frailty classes significantly impact symptom burden scores. Radiotherapy personnel can develop targeted frailty management strategies based on the internal heterogeneity and influencing factors of frailty to help patients prevent or reverse frailty development, thereby further alleviating patient symptom burden.
- Lung cancer,
- Radiotherapy,
- Enervation,
- Potential categories,
- Symptom disturbance

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References(39)

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