结直肠神经内分泌肿瘤的治疗进展

陈昌贤; 张丽菊; 姜晓明; 张振勇; 刘为军

doi:10.12259/j.issn.2095-610X.S20201242

结直肠神经内分泌肿瘤的治疗进展

doi: 10.12259/j.issn.2095-610X.S20201242

昆明理工大学附属昆华医院，云南省第一人民医院肛肠科，云南昆明　650032

基金项目: 国家自然科学基金资助项目（81960447）；云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2017FE467（-120）]

详细信息

作者简介:
陈昌贤（1993～），男，广西合浦人，在读硕士研究生，主要从事结直肠疾病研究工作

通讯作者:
刘为军，E-mail： 729368520@qq.com

中图分类号: R735.3⁺4
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- 文章访问数: 4504
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- 被引次数: 0
出版历程
- 收稿日期: 2020-02-29
- 刊出日期: 2019-12-26

Advances in Treatment of Colorectal Neuroendocrine Tumors

Dept. of Anorectal Diseases，Medical School & Affiliated Hospital Kunming University of Science and Technology，Kunming Yunnan 650032，China

摘要

摘要: 结直肠神经内分泌肿瘤以往被认为是罕见的肠道肿瘤，但近年来发病率不断升高。结直肠神经内分泌肿瘤多为惰性肿瘤，多无特殊症状，临床上易漏诊甚至误诊，大多数患者就诊时已是中晚期。该疾病的治疗主要依赖于外科手术治疗，近年来也衍生出了许多新领域，如微创技术、生物治疗、靶向治疗等。在提高疗效的基础上尽量降低并发症发生率，是医患双方的共同需求，因此该疾病的诊断和治疗需要外科医生更多的关注。
- 结直肠神经内分泌肿瘤 /
- 放化疗 /
- 手术 /
- 预后
Abstract: Colorectal neuroendocrine tumors were previously considered to be very rare intestinal tumors. However, with the raising of people's awareness of physical examination and the popularity of colonoscopy, the number of cases detected has been increasing rapidly. Colorectal neuroendocrine tumors are mostly inert tumors with no special symptoms; patient is not aware of it, so these tumors are easily missed or even misdiagnosed by less experienced doctors. The treatment of this disease relies more on surgical treatment. Many new technologies have been developed in recent years, such as minimally invasive technology, bio-therapy, targeted therapy. It is the common demand of both doctors and patients to reduce the incidence of complications on the basis of improving therapeutic effect. Making the diagnosis and treatment of this disease requires more attention and research by surgeons.
- Colorectal neuroendocrine tumors /
- Chemoradiotherapy /
- Surgery /
- Prognosis

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参考文献(35)

[1]	Dasari A,Shen C,Halperin D,et al. Trends in the incidence,prevalence,and survival outcomes in patients with neuroendocrine tumors in the united states[J]. JAMA Oncol,2017,3(10):1335-1342. doi: 10.1001/jamaoncol.2017.0589
[2]	Bustamante-Lopez L A,Nahas S C,Nahas C S R,et al. Is there a difference between right- versus left-sided colon cancers? Does side make any difference in long-term follow-up?[J]. Arq Bras Cir Dig,2019,32(4):e1479. doi: 10.1590/0102-672020190001e1479
[3]	Chaoyong Shen1,Yuan Yin,Huijiao Chen,et al. Neuroendocrine tumors of colon and rectum:Validation of clinical and prognostic values of the world health organization 2010 grading classifications and european neuroendocrine tumor society staging systems[J]. Oncotarget,2017,28(13):22123-22134.
[4]	朱雄增. 胃肠胰神经内分泌肿瘤新分类的临床意义[J].中华胃肠外科杂志,2013,16(1):12-14. doi: 10.3760/cma.j.issn.1671-0274.2013.01.004
[5]	Turaga K K,Kvols L K. Recent progress in the understanding,diagnosis,and treatment of gastroenteropancreatic neuroendocrine tumors[J]. CA Cancer J Clin,2011,61(2):113-132. doi: 10.3322/caac.20097
[6]	李洁,孙宇,吴佳怿. 胰腺和胃肠道来源神经内分泌肿瘤分类—2018 IARC/WHO分类框架共识解读[J].肿瘤综合治疗电子杂志,2018,4(4):16-20.
[7]	Anthony L B,Strosberg J R,Klimstra D S,et al. The NANETS consensus guidelines for the diagnosis and management of gastrointestinal neuroendocrine tumors(nets):Well-differentiated nets of the distal colon and rectum[J]. Pancreas,2010,39(6):767-774. doi: 10.1097/MPA.0b013e3181ec1261
[8]	袁华燕,程勇. 结直肠神经内分泌癌的诊疗进展[J].中外医疗,2019,38(10):195-198.
[9]	郑楚伊,施永恒,刘强,等. 113例直肠神经内分泌肿瘤的临床病理观察[J].上海交通大学学报(医学版),2019,39(3):297-303.
[10]	徐建明,梁后杰,秦叔逵,等. 中国胃肠胰神经内分泌肿瘤专家共识(2016年版)[J].临床肿瘤学杂志,2016,21(10):927-946.
[11]	石光锋,王晓霜. 直肠神经内分泌肿瘤的微创治疗[J].世界最新医学信息文摘,2016,16(95):70.
[12]	杨根源,郭晓红,施茜,等. 结扎装置辅助内镜下黏膜下层切除术与黏膜下层剥离术治疗直肠神经内分泌肿瘤的对照研究[J].胃肠病学和肝病学杂志,2016,25(2):155-158.
[13]	朱建华,郝凤媛,李楠. 直肠神经内分泌肿瘤内镜下诊疗的临床研究[J].中华保健医学杂志,2019,21(1):42-44.
[14]	Wang X,Xiang L,Li A,et al. Endoscopic submucosal dissection for the treatment of rectal carcinoid tumors 7-16 mm in diameter[J]. Int J Colorectal Dis,2015,30(3):375-380. doi: 10.1007/s00384-014-2117-2
[15]	Zhang D G,Luo S,Xiong F,et al. Endoloop ligation after endoscopic mucosal resection using a transparent cap:A novel method to treat small rectal carcinoid tumors[J]. World J Gastroenterol,2019,25(10):1259-1265. doi: 10.3748/wjg.v25.i10.1259
[16]	张莉,王李心,王国芬,等. EMR-C及ESD在直肠神经内分泌肿瘤治疗中的应用效果比较[J].结直肠肛门外科,2018,24(4):389-392.
[17]	中国胃肠胰神经内分泌肿瘤病理专家组. 中国胃肠胰神经内分泌肿瘤病理学诊断共识[J].中华病理学杂志,2011,40(4):257-262. doi: 10.3760/cma.j.issn.0529-5807.2011.04.010
[18]	任春成,李非,陈希琳,等. 经肛门内镜微创切除术治疗直肠神经内分泌肿瘤的疗效观察[J].结直肠肛门外科,2019,25(3):333-336.
[19]	姜鹏,张宏,丛进春,等. 腹腔镜与经肛门内镜微创手术切除直肠神经内分泌肿瘤的短期疗效比较[J].中国医刊,2018,53(11):1236-1240. doi: 10.3969/j.issn.1008-1070.2018.11.008
[20]	陈洛海,陈洁,周志伟. 胃肠道神经内分泌肿瘤治疗最新指南解读[J].中华胃肠外科杂志,2016,19(11):1201-1204. doi: 10.3760/cma.j.issn.1671-0274.2016.11.001
[21]	Hyde A J,Nassabein R,AlShareef A,et al. Eastern canadian gastrointestinal cancer consensus conference 2018[J]. Curr Oncol,2019,26(5):e665-e681.
[22]	戴广海,千年松. 胃肠胰神经内分泌肿瘤多学科综合治疗协作组诊疗模式专家共识[J].中国实用外科杂志,2017,37(1):46-47,66.
[23]	吴爽,韩宇. 胃肠胰神经内分泌肿瘤药物治疗进展[J].中国肿瘤临床,2018,45(8):422-426. doi: 10.3969/j.issn.1000-8179.2018.08.144
[24]	Garcia-Carbonero R,Rinke A,Valle J W,et al. ENETS consensus guidelines for the standards of care in neuroendocrine neoplasms. Systemic therapy 2:Chemotherapy[J]. Neuroendocrinology,2017,105(3):281-294. doi: 10.1159/000473892
[25]	王麒宇,王亚旭. 结直肠神经内分泌肿瘤的治疗进展[J].世界最新医学信息文摘,2019,19(99):137-138,140.
[26]	Reuther C,Heinzle V,Nolting S,et al. The HDM2(MDM2)inhibitor NVP-CGM097 inhibits tumor cell proliferation and shows additive effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 cascade in the p53wild type neuroendocrine tumor cell line GOT1[J]. Neuroendocrinology,2018,106(1):1-19. doi: 10.1159/000453369
[27]	裴效瑞,张权,卢德宝. 胃肠道神经内分泌肿瘤患者的药物治疗进展[J].医疗装备,2018,31(21):202-204. doi: 10.3969/j.issn.1002-2376.2018.21.142
[28]	Sorbye H,Kong G,Grozinsky-Glasberg S. PRRT in high-grade gastroenteropancreatic neuroendocrine neoplasms(WHO G3)[J]. Endocr Relat Cancer,2019,27(3):67-77.
[29]	勾贺,孟宇,宋敏. 神经内分泌肿瘤内科治疗的研究进展[J].河南医学研究,2019,28(9):1727-1729. doi: 10.3969/j.issn.1004-437X.2019.09.105
[30]	Lee L,Ito T,Jensen R T. Everolimus in the treatment of neuroendocrine tumors:Efficacy,side-effects,resistance,and factors affecting its place in the treatment sequence[J]. Expert Opin Pharmacother,2018,19(8):909-928. doi: 10.1080/14656566.2018.1476492
[31]	Wang Z J,An K,Li R,et al. Analysis of 72 patients with colorectal high-grade neuroendocrine neoplasms from three Chinese hospitals[J]. World J Gastroenterol,2019,25(34):5197-5209. doi: 10.3748/wjg.v25.i34.5197
[32]	范振列,杨召,乔友林,等. 109例直肠神经内分泌肿瘤患者的临床病理特征与预后分析[J].中国肿瘤,2017,26(4):308-314.
[33]	宋宝荣,张霞,徐烨,等. 婚姻状态对结直肠神经内分泌肿瘤患者远期预后的影响[J].同济大学学报(医学版),2017,38(4):81-85,92.
[34]	黄玉庭,贾茹,徐倩,等. 不同分期结肠与直肠神经内分泌肿瘤的预后分析[J].中华肿瘤杂志,2019,41(2):146-151. doi: 10.3760/cma.j.issn.0253-3766.2019.02.013
[35]	Man D,Wu J,Shen Z,et al. Prognosis of patients with neuroendocrine tumor:A SEER database analysis[J]. Cancer Manag Res,2018,10(1):5629-3568.

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