Expression Characteristics of Inflammatory Factors in the Serum of Patients with Adolescence Polycystic Ovary Syndrome
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摘要:
目的 探讨血清CRP、TNF-α及IL-6水平在疑似青春期多囊卵巢综合征中的表达特点。 方法 选择符合纳入标准的80例疑似青春期PCOS患者作为研究对象（即疑似PCOS组），60 例青春期PCOS患者作为PCOS组，同期50例正常青春期女性作为对照组；将80例研究对象分为2个亚组：OA + HA组（40例）、OA+PCOM组（40例）。所有受试者检测血清卵泡刺激素（FSH）、黄体生成素（LH）、睾酮（T）、雌激素（E2）、泌乳素（PRL）；检测白介素-6（Interleukin 6，IL-6）、C反应蛋白（C-reactive protein，CRP）及肿瘤坏死因子-α（TNF-α）水平。 结果 疑似PCOS组患者血清CRP值、IL-6值明显高于对照组，差异具有统计学意义（P < 0.05）；OA + HA组患者血清CRP值、TNF-α值及IL-6值明显高于OA + PCOM组，差异具有统计学意义（P < 0.05）。 结论 炎症因子IL-6、CRP在疑似PCOS青春期患者中具有高水平的表达，可协助早期识别青春期PCOS，为疑似PCOS患者的早期干预提供依据。 -
关键词:
- 青春期多囊卵巢综合征 /
- 炎性因子 /
- 早期干预
Abstract:Objective To study the expression of CRP, IL-6 and TNF-a in the serum of patients with the suspected adolescence polycystic ovary syndrome （PCOS）. Methods 80 patients with the suspected adolescence polycystic ovary syndrome （PCOS）were selected as the object of study （suspected adolescence PCOS group）, and 60 patients with adolescence PCOS were chosen as the PCOS group and60 normal adolescence women selected as the control group. The 80 subjects were divided into two subgroups: OA+PCOM group （40 cases） and OA+HA group （40 cases）. The levels of FSH, LH, T, E2, PRL, CRP, IL-6, TNF-a were detected. Results Serum levels of CRP、IL-6 in suspected adolescence PCOS group were significantly higher than those in the control group （P < 0.05）. Serum levels of CRP, TNF-a and IL-6 in OA+HA group were significantly higher than those in OA+PCOM group （P < 0.05）. Conclusion The high levels of IL-6 and CRP in patients with the suspected adolescence PCOS may help to identify the early puberty and provide the evidence for the early intervention of adolescence PCOS. -
表 1 疑似PCOS组与对照组一般资料比较（
$\bar x \pm s $ ）Table 1. Comparison of general information between Suspected Adolescence PCOS group and the control group （
$\bar x \pm s $ ）组别 n 年龄（岁） 初潮年龄（岁） BMI（kg／m2） 对照组 50 16.32 ± 1.96 12.87 ± 1.08 20.56 ± 2.93 疑似PCOS组 80 16.08 ± 2.33 12.63 ± 0.88 21.33 ± 2.55 t 0.606 1.385 −1.581 P 0.545 0.169 0.116 
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表 2 疑似PCOS组与PCOS组一般资料比较（
$\bar x \pm s $ ）Table 2. Comparison of general information between Suspected Adolescence PCOS group and PCOS group （
$\bar x \pm s $ ）组别 n 年龄（岁） 初潮年龄（岁） BMI（kg／m2） 对照组 50 16.32 ± 1.96 12.87 ± 1.08 20.56 ± 2.93 疑似PCOS组 80 16.08 ± 2.33 12.63 ± 0.88 21.33 ± 2.55 t 0.780 −0.352 0.354 P 0.437 0.726 0.724
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表 3 疑似PCOS组与对照组血清IL-6、CRP及TNF-α水平比较（
$\bar x \pm s $ ）Table 3. Comparison of the levels of IL-6、CRP、TNF-a between Suspected Adolescence PCOS group and the control group （
$\bar x \pm s $ ）组别 n CRP（mg/L） TNF-α（pg/mL） IL-6（pg/mL） 对照组 50 3.48 ± 0.59 0.99 ± 0.33 7.03 ± 1.38 疑似PCOS组 80 8.91 ± 0.81 0.95 ± 0.78 22.53 ± 1.93 t −41.057 0.344 −49.410 P 0.000* 0.732 0.000* *P < 0.05。
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表 4 疑似PCOS组与PCOS组血清IL-6、CRP及TNF-α水平比较（
$\bar x \pm s $ ）Table 4. Comparison of the levels of IL-6、CRP、TNF-a between Suspected Adolescence PCOS group and PCOS group （
$\bar x \pm s $ ）组别 n CRP（mg/L） TNF-α（pg/mL） IL-6（pg/mL） PCOS组 60 9.32 ± 0.95 1.93 ± 0.49 22.05 ± 2.77 疑似PCOS组 80 8.91 ± 0.81 0.95 ± 0.78 22.53 ± 1.93 t 2.751 7.951 0.326 P 0.000* 0.000* 0.801 *P < 0.05。
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表 5 OA+HA组与OA+PCOM组炎症因子水平比较（
$\bar x \pm s $ ）Table 5. Comparison of the levels of inflammatory factors between OA+PCOM Group and OA+HA group （
$\bar x \pm s $ ）组别 n CRP（mg/L） TNF-α（pg/mL） IL-6（pg/mL） OA+HA组 40 9.12 ± 1.08 0.99 ± 0.27 23.90 ± 4.08 OA+PCOM组 40 4.01 ± 0.52 0.78 ± 0.42 15.71 ± 2.92 t 26.962 2.660 10.324 P 0.000* 0.009* 0.006* *P < 0.05。
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