IL-10与自身免疫病的研究进展

陈墨; 周泽平

IL-10与自身免疫病的研究进展

陈墨,
周泽平

昆明医科大学第二附属医院血液科

基金项目:

作者简介：陈墨 (1992~) , 男, 湖北黄石市人, 在读硕士研究生, 主要从事血液科临床工作.; 周泽平.E-mail:zhouzeping@outlook.com男, 43岁, 博士, 教授, 博士研究生导师.2007年毕业于中国协和医科大学.现为昆明医科大学第二附属医院血液科主任, 云南省中青年学术及技术带头人后备人才, 云南省高层次卫生技术人才学科带头人, 云南省省级临床重点专科负责人, 昆明医科大学创新团队负责人.中华医学会血液学分会止血与血栓学组委员、青年委员, 云南省血液学会副主任委员, 中国研究型医院学会生物治疗学专委会委员, 中国老年医学会血液学分会委员, 昆明医科大学第七届学术委员会委员等.主持国家自然科学基金3项, 省部级项目8项, 发表论文50篇, 其中SCI收录23篇.参编英文专著1部及中文专著5部.;

基金：国家自然科学基金资助项目 (81560029); 云南省中青年学术及技术带头人后备人才基金资助项目 (2013HB088);

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出版历程
- 收稿日期: 2017-11-19

The Progress of IL-10 and Autoimmune Diseases

Chen Mo ,
Zhou Ze Ping

Funds:

基金：国家自然科学基金资助项目 (81560029); 云南省中青年学术及技术带头人后备人才基金资助项目 (2013HB088);

摘要

摘要: IL-10是一种被广泛表达的单链糖蛋白多效细胞因子, 既可以由适应性免疫细胞产生也可以由固有免疫细胞产生.IL-10的特异性受体是复合物, 由IL-10R1和IL-10R2两个亚单位构成, 主要通过JAK-STAT通路发挥生物学功能.IL-10作为一种关键的抗炎细胞因子参与机体免疫调节, 在多种自身免疫病中发挥重要作用.综合整理近几年的最新研究成果, 探讨IL-10与自身免疫病的关系.
- IL-10 /
- 免疫调节 /
- 自身免疫病
Abstract: Interleukin-10 (IL-10) , a single strand glycoprotein, is produced by both adaptive and innate immune cells. IL-10 specific receptor as a complex consists of two submits IL-10 R1 and IL-10 R2. IL-10 mainly plays biological functions via JAK-STAT signaling pathway. IL-10 is a crucial anti-inflammation cytokine taking part in immune regulation and having significant effect on autoimmune diseases. This paper reviews the relationships between IL-10 and autoimmune diseases according to research achievements in recent years.
- Interleukin-10 /
- Immune regulation /
- Autoimmune diseases

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参考文献(23)

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