DRD1在神经系统疾病和功能中的研究进展

李瑾瑜; 冯良升; 高扬; 李钰; 吴帮旭; 邹英鹰

DRD1在神经系统疾病和功能中的研究进展

1.
昆明医科大学第一临床医学院，云南昆明　650032
2.
昆明医科大学基础医学院，云南昆明　650500

基金项目: 国家自然科学基金资助项目（32060184）；校级大学生创新创业训练基金资助项目（2023CXD267）

详细信息

作者简介:
李瑾瑜（2004～），女，云南昆明人，在读本科生

通讯作者:
邹英鹰，E-mail：zouyingyingzyy@126.com

中图分类号: R741.02
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- 文章访问数: 248
- HTML全文浏览量: 233
- PDF下载量: 13
- 被引次数: 0
出版历程
- 收稿日期: 2024-01-11
- 网络出版日期: 2024-04-29

Research Progress of DRD1 in Neurological Disorders and Functions

1.
The 1st Affiliated Hospital. of Kunming Medical University，Kunming Yunnan 650032
2.
The School of Basic Medicine. of Kunming Medical University，Kunming Yunnan 650500，China

摘要

摘要: 多巴胺D1受体（dopamine D1 receptor ，DRD1）是目前已知神经系统表达最广泛的多巴胺受体亚型。DRD1能通过多种信号通路发挥运动、情感、认知、学习记忆以及神经内分泌等功能。这些功能可能与帕金森综合征、精神分裂症、抑郁症等精神疾病以及免疫有关。而DRD1的表达变化通常提示了神经系统功能的改变。因此DRD1可以作为神经系统疾病和功能变化的潜在指标和神经系统疾病治疗的潜在靶点。综述了DRD1在神经系统中的分布和功能，重点强调了DRD1与神经系统相关的信号通路。
- 多巴胺受体 /
- 神经系统 /
- DRD1 /
- 多巴胺
Abstract: Dopamine D1 receptor （DRD1） is currently known as the dopamine receptor subtype with the most widespread expression in the nervous system. DRD1 plays a role in various signaling pathways to perform many functions such as movement, emotion, cognition, learning and memory, as well as neuroendocrine activities. These functions may be associated with conditions like Parkinson's syndrome, schizophrenia, depression, and immune responses. Changes in the expression of DRD1 often indicate alterations in neurological functions. Therefore, DRD1 has the potential to serve as an indicator of neurological disorders and functional changes, as well as a potential target for the treatment of neurological diseases. This article reviews the distribution and functions of DRD1 in the nervous system, with a particular emphasis on DRD1's involvement in signaling pathways related to the nervous system.
- Dopamine receptor /
- Nervous system /
- DRD1 /
- DA

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参考文献(61)

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DRD1在神经系统疾病和功能中的研究进展

作者简介:
李瑾瑜（2004～），女，云南昆明人，在读本科生

通讯作者:
邹英鹰，E-mail：zouyingyingzyy@126.com

计量

Research Progress of DRD1 in Neurological Disorders and Functions

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目录

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DRD1在神经系统疾病和功能中的研究进展

作者简介: 李瑾瑜（2004～），女，云南昆明人，在读本科生

通讯作者: 邹英鹰，E-mail：zouyingyingzyy@126.com

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出版历程

Research Progress of DRD1 in Neurological Disorders and Functions

计量

出版历程

目录

作者简介:
李瑾瑜（2004～），女，云南昆明人，在读本科生

通讯作者:
邹英鹰，E-mail：zouyingyingzyy@126.com