2025 Vol. 46, No. 1

Expert Forum
The Role of Macrophage Polarization in Thrombotic Diseases
Haopeng SHENTU, Jing YANG, Weiqing GE, Tao ZHOU, En SONG
2025, 46(1): 1-8. doi: 10.12259/j.issn.2095-610X.S20250101
Abstract(304) HTML PDF(25)
Abstract:
Thrombotic diseases refer to a group of conditions characterized by abnormal blood coagulation within blood vessels, leading to the formation of blood clots and a series of clinical symptoms. This includes diseases such as deep vein thrombosis in the...
Original Articles Basic of Medicine
Refractive Progression and Related Factors in Myopic School-age Children in Ethnic Minority Areas of Yunnan
Maosen CHEN, Dafeng HUANG, Peiqian LI, Jie XIAO, Zixue MA, Chao FAN, Yayi DAI, Han ZHANG, Ying HUANG
2025, 46(1): 9-15. doi: 10.12259/j.issn.2095-610X.S20250102
Abstract(210) HTML PDF(6)
Abstract:
Objective To understand the refractive progression of myopic school-aged children in ethnic minority areas of Yunnan and explore related factors. Methods Based on an existing cohort, a first follow-up survey was conducted from October 2020 to June 2...
Signal Mining and Analysis of Adverse Events of Azithromycin Based FAERS Database
Qinglan PENG, Jialu LUO, Jiayi YU, Kaixin WANG, Fang WU, Chuanzhi XU
2025, 46(1): 16-22. doi: 10.12259/j.issn.2095-610X.S20250103
Abstract(946) HTML PDF(40)
Abstract:
Objective To explore and analyze adverse drug events (ADE) signals of azithromycin, identify common adverse events and suspected adverse reactions that occur easily in the real clinical application of azithromycin. Methods The adverse drug event rep...
Identify Key Mitochondrial Autophagy Genes in Schizophrenia through Integrated Bioinformatics Approaches
Kun LIAN, Yongmei LI, Chenglong SHI, Yilan CHEN, Lei ZHANG, Wei YANG, Xiufeng XU
2025, 46(1): 23-35. doi: 10.12259/j.issn.2095-610X.S20250104
Abstract(302) HTML PDF(16)
Abstract:
Objective To utilize single-cell and peripheral blood transcriptomic data from 3D brain organoids, combined with machine learning, to analyze the role of mitochondrial autophagy genes in schizophrenia (SCZ). Methods By integrating two machine learni...
Galangin Inhibits the Migration and Invasion of Cervical Cancer Hela Cells Through Hippo/YAP Pathway
Yiran YAN, Chengwan SHEN, Xiangyu SHANG, Chan FENG, Jinqiu LI, Hasim AXIANGU
2025, 46(1): 36-42. doi: 10.12259/j.issn.2095-610X.S20250105
Abstract(268) HTML PDF(16)
Abstract:
Objective To investigate the effects of galangin on the migration and invasion abilities of cervical cancer Hela cells and its potential mechanisms. Methods Hela cells were treated with different concentrations of galangin (0, 5, 10, 20, 40, 60, 80,...
Clinical Research
Clinical Efficacy of Immediate Radical Surgery for Locally Advanced Prostate Cancer
Wei WANG, Sheng LIU, Hongqing ZHOU, Mingsheng LIU, Pingbo XIE, Feng GUO, Guanyu CHEN
2025, 46(1): 43-50. doi: 10.12259/j.issn.2095-610X.S20250106
Abstract(246) HTML PDF(3)
Abstract:
Objective To explore the clinical efficacy and safety of immediate laparoscopic radical prostatectomy immediately following the diagnosis of locally advanced prostate cancer. Methods A retrospective analysis was performed for 63 patients with locall...
Analysis of Antiviral Efficacy and Safety in Patients with Chronic Hepatitis B in Indeterminate Phase
Qian AI, Zhirong ZHAO, Yue WU, Haiwen LI, Shenghao LI, Yongrui YANG
2025, 46(1): 51-59. doi: 10.12259/j.issn.2095-610X.S20250107
Abstract(270) HTML PDF(11)
Abstract:
Objective To analysis the efficacy and safety of antiviral therapy in patients with chronic hepatitis B virus in indeterminate phase based on the new guidelines (2022 Edition of the Guidelines for the Prevention and Treatment of Chronic Hepatitis B)....
Status and Influencing Factors of Stigma in Lung Cancer Patients
Qianrong YANG, Xue CAO, Jiao YANG, Yanqiu ZHAO, Nan SHEN, Yajiao SUN
2025, 46(1): 60-67. doi: 10.12259/j.issn.2095-610X.S20250108
Abstract(228) HTML PDF(3)
Abstract:
Objective To understand the current status of stigma among lung cancer patients in Yunnan and analyze its influencing factors. Methods A convenience sampling method was employed to select 248 lung cancer patients from a tertiary cancer hospital in Y...
Psychological Characteristics and Pain Tolerance of Adolescents with Depression Experiencing Self-injury or Suicidality
Linyuan XU, Huajun ZHAO, Chao LI, Yan SU, Shihua BAO, Lei WU, Qingwei LI, Bingkui ZHANG
2025, 46(1): 68-77. doi: 10.12259/j.issn.2095-610X.S20250109
Abstract(558) HTML PDF(17)
Abstract:
Objective To explore the influencing factors of self injury or suicide in adolescent patients with depression. Methods A total of 96 adolescents who were diagnosed with depressive disorder at Yunnan Psychiatirc Hospital and Kunming Psychiatirc Hospi...
GJB4 Gene Expression in Relation to Clinical and Pathological Features of Pancreatic Cancer Patients
Runlin FENG, Zongqi DENG, Mengyao WU, Yunna WANG, Yu WANG, Guilan LIU, Yanping TAO
2025, 46(1): 78-86. doi: 10.12259/j.issn.2095-610X.S20250110
Abstract(468) HTML PDF(14)
Abstract:
Objective To investigate the expression of GJB4 gene in pancreatic cancer tissue and its correlation with clinicopathology. Methods The expression levels of GJB4 mRNA in pancreatic cancer and adjacent cancer tissues were analyzed using bioinformatic...
Characteristics of Refractive Development Parameters and Their Effects on Refractive Status in Children Aged 7~12 Years
Jianmei CHA, Fangbing YAN, Yang ZHANG, Can YU
2025, 46(1): 87-92. doi: 10.12259/j.issn.2095-610X.S20250111
Abstract(165) HTML PDF(4)
Abstract:
Objective To investigate the refractive development parameters of primary school students aged 7 to 12 years in Chuxiong City, Yunnan Province, analyze their relationship with equivalent spherical power (SE), and evaluate the monitoring role of refra...
Preoperative CL-11,Urinary Nitrite,U-HBP,and Their Correlation with Postoperative Urinary Sepsis in Patients with Kidney Stones and Their Predictive Significance
Tao CHEN, Haiyan ZHANG, Shunhui YUAN, Xiangmeng LI, Jian CHEN
2025, 46(1): 93-98. doi: 10.12259/j.issn.2095-610X.S20250112
Abstract(157) HTML PDF(3)
Abstract:
Objective To analyze the correlation of preoperative collagen lectin-11 (CL-11), urinary nitrite, and urinary heparin-binding protein (U-HBP) with postoperative urinary sepsis (US) in patients with kidney stones, and to explore their predictive value...
Real-time Shear Wave Elastography in Evaluating Changes in Muscle and Tendon Tone of the Quadriceps in Parkinson's Disease Patients
Li LUO, Yue SUN, Yuxue WANG, Yongping LU
2025, 46(1): 99-104. doi: 10.12259/j.issn.2095-610X.S20250113
Abstract(250) HTML PDF(4)
Abstract:
Objective To measure the Young's modulus values of the quadriceps muscles (rectus femoris, vastus intermedius, vastus lateralis, vastus medialis) and tendons in Parkinson's disease (PD) patients using real-time shear wave elastography (SWE) technolog...
Mediating Effect of Hope on Self-perceived Burden and Quality of Life in Patients with Recurrent Malignant Tumor
Yaoyao PEI, Zhangying XU, Wei XIAO, Xiuxian LI, Tingting HU
2025, 46(1): 105-110. doi: 10.12259/j.issn.2095-610X.S20250114
Abstract(163) HTML PDF(4)
Abstract:
Objective To explore the mediating effect of hope between self-perceived burden and quality of life in patients with recurrent malignant tumors. Methods A cross-sectional survey was conducted using convenience sampling, selecting 204 patients with re...
Predictive Value of KIAA1199 and Linc00673 Genes on Chemotherapy Efficacy in Non-small Cell Lung Cancer
Huimin YU, Xin XIN, Zhiwei LIANG
2025, 46(1): 111-116. doi: 10.12259/j.issn.2095-610X.S20250115
Abstract(125) HTML PDF(3)
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Objective To explore the expression changes of KIAA1199 and Linc00673 genes in non-small cell lung cancer patients before and after chemotherapy, and to further evaluate the potential value of these two genes as molecular markers in predicting chemot...
Effects and Efficacy Evaluation of Modified Prone Ventilation Combined with Bronchoscopic Alveolar Lavage on Respiratory Mechanics and Hemodynamics in Children with ARDS
Yao HOU, Nan KONG, Yuqin WU, Lin WANG, Ting WANG
2025, 46(1): 117-122. doi: 10.12259/j.issn.2095-610X.S20250117
Abstract(245) HTML PDF(3)
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Objective To explore the effects of modified prone ventilation combined with bronchoscopic alveolar lavage on respiratory mechanics and hemodynamics in children with Acute Respiratory Distress Syndrome (ARDS), as well as to evaluate the clinical trea...
Levels of IGF-1 and IGFBP-3 in Childhood Obesity and Their Diagnostic Value
Lisi LUO, Qingxiong YANG, Yan WANG, Sixiang LIU, Zhen XU, Yu LING
2025, 46(1): 123-128. doi: 10.12259/j.issn.2095-610X.S20250118
Abstract(204) HTML PDF(8)
Abstract:
Objective To explore the expression changes of IGF-1 and IGFBP-3 in childhood obesity and their diagnostic value. Methods Blood samples and corresponding clinical information were collected from patients attending Kunming Children's Hospital from De...
Exploratory Study on the Ultrasound Characteristics of the Vagus Nerve in a Healthy Han Population in a Hospital in Qujing, Yunnan
Lingli HOU, Yan CHENG, Fang YANG, Junsu YANG, Zizhen ZHANG, Jianjian BAO, Guohui ZHANG, Kang DU
2025, 46(1): 129-135. doi: 10.12259/j.issn.2095-610X.S20250119
Abstract(197) HTML PDF(12)
Abstract:
Objective To explore the characteristics of the cross-sectional area (CSA) of the vagus nerve in a healthy population in Qujing, Yunnan, and its correlation with demographic characteristics. Methods High-resolution nerve ultrasound examinations were...
Expression,Diagnostic Value,and Correlation Analysis of PCT,WBC,and CRP with CPIS Score in ICU Respiratory Infections
Luying TI, Hongyu YANG, Li LI, Dongmei WANG, Yasong YUAN, Bo ZHANG
2025, 46(1): 136-141. doi: 10.12259/j.issn.2095-610X.S20250120
Abstract(218) HTML PDF(9)
Abstract:
Objective To analyze the expression and diagnostic value of procalcitonin (PCT), white blood cell count (WBC), and C-reactive protein (CRP) in respiratory infections in the intensive care unit (ICU), and their correlation with the clinical pulmonary ...
Correlations between CD4+CD25+Treg,sCD30 and Clinical Characteristics of Lymphoma and Their Value in Predicting Infection after Chemotherapy
Chunyan LIU, Bingqing CHANG, Chao LI, Xin REN, Xiaoqin LIU
2025, 46(1): 142-147. doi: 10.12259/j.issn.2095-610X.S20250121
Abstract(742) HTML PDF(6)
Abstract:
Objective To investigate the expression and significance of CD4+CD25+ regulatory T cells (CD4+CD25+Treg) and soluble CD30 (sCD30) in peripheral blood of lymphoma patients. Methods A total of 83 lymphoma patients admitted to Beijing Aerospace General ...
Reviews
Application of Bacteriophages in Common Infectious Diseases of the Oral Cavity
Hao HUANG, Xuelin LI, Zehua HAN, Lin CHANG, Pengfei ZHU, Yingying XIANG
2025, 46(1): 148-153. doi: 10.12259/j.issn.2095-610X.S20250122
Abstract(250) HTML PDF(13)
Abstract:
Bacteriophages possess the ability to infect and kill bacteria and have now been applied in various oral diseases, providing new insights for the prevention and treatment of oral diseases. They are expected to become a novel biological antibacterial ...
Classification and Treatment of Solitary Iliac Artery Aneurysms
Mengjia WANG, Kaixiong QING, Lingfeng ZHAO
2025, 46(1): 154-159. doi: 10.12259/j.issn.2095-610X.S20250123
Abstract(215) HTML PDF(13)
Abstract:
Solitay iliac aneurysms are a rare clinical condition characterized by insidious onset. Once they rupture, treatment becomes difficult, and the mortality rate is extremely high. Therefore, it is extremely important to detect the disease, classify it ...
Teaching Research
The Impact of a Three-phase School-Based Rehabilitation Outpatient Clinical Internship Model on the Clinical Practice Skills and Employment Intentions of Physical Therapy Students
Fanyuan MENG, Moxian CHEN, Kerong LI, Zhizhong XING, Lijuan AO, Xuan XU
2025, 46(1): 160-166. doi: 10.12259/j.issn.2095-610X.S20250124
Abstract(204) HTML PDF(4)
Abstract:
Objective To explore the impact of the clinical internship model at the on-campus rehabilitation outpatient clinic on the clinical practice abilities and employment intentions of students in the physical therapy program. Methods A total of 60 studen...
Nursing Forum
Impact of Temperature Intervention on Pain and Catheterization Outcomes in Premature Infants Undergoing PICC Placement
Yonglin QI, Fang WANG, Xiangjuan KUANG, Lijuan YIN
2025, 46(1): 167-172. doi: 10.12259/j.issn.2095-610X.S20250125
Abstract(126) HTML PDF(10)
Abstract:
Objective To investigate the impact of temperature intervention on pain and catheterization outcomes in premature infants undergoing peripherally inserted central catheter (PICC) placement. Methods A total of 70 premature infants who underwent PICC ...