Antagonistic Effect of Total Flavonoids of <i>Panax notoginseng</i> on Osteoporosis Induced by Glucocorticoid

Li-yuan WU; Su-yi LUO; Yong-jie GU; Qi-peng WANG; Jia-hao XU

doi:10.12259/j.issn.2095-610X.S20201117

Volume 41 Issue 11

Dec. 2020

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Li-yuan WU, Su-yi LUO, Yong-jie GU, Qi-peng WANG, Jia-hao XU. Antagonistic Effect of Total Flavonoids of Panax notoginseng on Osteoporosis Induced by Glucocorticoid[J]. Journal of Kunming Medical University, 2020, 41(11): 25-29. doi: 10.12259/j.issn.2095-610X.S20201117

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Antagonistic Effect of Total Flavonoids of Panax notoginseng on Osteoporosis Induced by Glucocorticoid

doi: 10.12259/j.issn.2095-610X.S20201117

Basic Medical College of Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2020-08-12
Available Online: 2020-12-03
Publish Date: 2020-11-25

Abstract

Abstract

Objective To study the antagonistic effect of total flavonoids of Panax notoginseng on osteoporosis induced by glucocorticoid and its possible mechanism. Methods Fifty female SD rats（SPF-grade）weighing about 170 g were randomly divided into five groups（10 / group）: normal control group, model group（hormone group）and high, medium and low dose treatment group（hormone + drug group）of total flavonoids of Panax notoginseng. Dexamethasone（2.5 mg/kg）was injected intramuscularly twice a week in the model group and total flavonoids of Panax notoginseng treatment groups. At the same time, the three treatment groups were given total flavonoids of Panax notoginseng 275 mg/（kg·d）, 137.5 mg/（kg·d）and 68.75 mg/（kg·d）by intragastric administration once a day. The experimental period was 9 weeks. After 9 weeks, bone mineral density（BMD）and indexes reflecting biomechanical properties of femur, serum biochemical indexes were measured. Results Compared with the normal group, the bone mineral density of femur, bone biomechanical properties and the serum calcium level decreased significantly, the serum phosphorus level and the serum alkaline phosphatase activity increased significantly in the model group（P < 0.05）. Compared with the model group, the bone mineral density, bone biomechanical properties and the serum calcium level increased significantly, the serum phosphorus level and the serum alkaline phosphatase activity decreased significantly in the high and medium dose treatment group of total flavonoids of Panax notoginseng（P < 0.05）. Conclusions Total flavonoids of Panax notoginseng can increase the bone density and improve the biomechanical properties of bone in glucocorticoid-induced osteoporosis rats. It has an antagonistic effect on osteoporosis induced by glucocorticoid. The mechanism of action is related to the inhibition of bone absorption and the imbalance of calcium and phosphorus metabolism induced by glucocorticoid.
- Total flavonoids of Panax notoginseng,
- Glucocorticoid,
- Osteoporosis,
- Bone mineral density,
- Bone biomechanical property

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References(15)

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