Volume 41 Issue 11
Dec.  2020
Turn off MathJax
Article Contents
Xu XU, Li-yong WU, Ming-li ZHOU, Guo-fu ZHU. Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients[J]. Journal of Kunming Medical University, 2020, 41(11): 56-61. doi: 10.12259/j.issn.2095-610X.S20201119
Citation: Xu XU, Li-yong WU, Ming-li ZHOU, Guo-fu ZHU. Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients[J]. Journal of Kunming Medical University, 2020, 41(11): 56-61. doi: 10.12259/j.issn.2095-610X.S20201119

Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients

doi: 10.12259/j.issn.2095-610X.S20201119
  • Received Date: 2020-10-12
    Available Online: 2020-12-03
  • Publish Date: 2020-11-25
  •   Objectives  To investigate the association between microRNA-146a(miR-146a)and the plaque stability in patients with coronary heart disease.  Methods  Real-time PCR was used to measure miR-146a expression in 324 patients. ELISA was used to measure the level of hs-CRP, IL-6 and IL-8. Coronary angiography was used to evaluate the degree of coronary artery stenosis. Intravascular ultrasound(IVUS)was used to evaluate the plaque stability of coronary stenotic lesions.  Results  (1)The levels of hs-CRP, IL-6 and IL-8 were significantly increased in the UAP and AMI groups compared with the CPS groups(P < 0.01).(2)The miR-146a expression in peripheral blood mononuclear cells(PBMCs)and plasma was significantly higher in CAD patients than those in non-CAD group(P < 0.05, P < 0.001).(3)The miR-146a expression in PBMCs was higher in SAP, UAP and AMI group than CPS group(P < 0.01, P < 0.001, P < 0.001). The expression patterns of miR-146a in plasma was consistent with that of PBMCs.(4)The expression of miR-146a in PBMCs and plasma were significantly higher in vulnerable plaque group than those in stable plaque group(P < 0.05).(5)The level of miR-146a in PBMCs and plasma was significantly higher in soft plaque group than those in fibrous plaque group and calcified plaque group(P < 0.05).  Conclusions  The expression of miR-146a is associated with the plaque stability of coronary stenotic lesions.
  • loading
  • [1]
    胡盛寿,高润霖,刘力生,等. 《中国心血管病报告2018》概要[J].中国循环杂志,2019,34(3):209-220. doi: 10.3969/j.issn.1000-3614.2019.03.001
    [2]
    Geovanini G R,Libby P. Atherosclerosis and inflammation:overview and updates[J]. Clin Sci(Lond),2018,132(12):1243-1252. doi: 10.1042/CS20180306
    [3]
    Zhong L,Simard M J,Huot J. Endothelial microRNAs regulating the NF-κB pathway and cell adhesion molecules during inflammation[J]. FASEB J,2018,32(8):4070-4084. doi: 10.1096/fj.201701536R
    [4]
    Churov A,Summerhill V,Grechko A,et al. MicroRNAs as potential biomarkers in atherosclerosis[J]. Int J Mol Sci,2019,20(22):5547. doi: 10.3390/ijms20225547
    [5]
    Bostjancic E,Glavac D. Importance of microRNAs in skin morphogenesis and diseases[J]. Acta Dermatovenerol Alp Panonica Adriat,2008,17(3):95-102.
    [6]
    Stanczyk J,Pedrioli D M,Brentano F,et al. Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis[J]. Arthritis Rheum,2008,58(4):1001-1009. doi: 10.1002/art.23386
    [7]
    Chen X,Gao Q,Zhou L,et al. MiR-146a alleviates inflammation of acute gouty arthritis rats through TLR4/MyD88 signal transduction pathway[J]. Eur Rev Med Pharmacol Sci,2019,23(21):9230-9237.
    [8]
    Yao R,Ma Y,Du Y,et al. The altered expression of inflammation-related microRNAs with microRNA-155 expression correlates with Th17 differentiation in patients with acute coronary syndrome[J]. Cell Mol Immunol,2011,8(6):486-495. doi: 10.1038/cmi.2011.22
    [9]
    Zhu G F,Yang L X,Guo R W,et al. microRNA-155 is inversely associated with severity of coronary stenotic lesions calculated by the Gensini score[J]. Coron Artery Dis,2014,25(4):304-310. doi: 10.1097/MCA.0000000000000088
    [10]
    Mintz G S,Nissen S E,Anderson W D,et al. American college of cardiology clinical expert consensus document on standards for acquisition,measurement and reporting of Intravascular Ultrasound Studies(IVUS). A report of the American college of cardiology task force on clinical expert consensus documents[J]. J Am Coll Cardiol,2001,37(5):1478-1492. doi: 10.1016/S0735-1097(01)01175-5
    [11]
    Endo M,Hibi K,Shimizu T,et al. Impact of ultrasound attenuation and plaque rupture as detected by intravascular ultrasound on the incidence of no-reflow phenomenon after percutaneous coronary intervention in ST-segment elevation myocardial infarction[J]. J Am Coll Cardiol Intv,2010,3(5):540-549. doi: 10.1016/j.jcin.2010.01.015
    [12]
    Livak K J,Schmittgen T D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))Method[J]. Methods,2001,25(4):402-408. doi: 10.1006/meth.2001.1262
    [13]
    Tayefi M,Tajfard M,Saffar S,et al. hs-CRP is strongly associated with coronary heart disease(CHD):A data mining approach using decision tree algorithm[J]. Comput Methods Programs Biomed,2017,141:105-109. doi: 10.1016/j.cmpb.2017.02.001
    [14]
    Tajfard M,Latiff L A,Rahimi H R,et al. Serum concentrations of MCP-1 and IL-6 in combination predict the presence of coronary artery disease and mortality in subjects undergoing coronary angiography[J]. Mol Cell Biochem,2017,435(1-2):37-45. doi: 10.1007/s11010-017-3054-5
    [15]
    Glaser R,Selzer F,Faxon D P,et al. Clinical progression of incidental,asymptomatic lesions discovered during culprit vessel coronary intervention[J]. Circulation,2005,111(2):143-149. doi: 10.1161/01.CIR.0000150335.01285.12
    [16]
    Taganov K D,Boldin M P,Chang K J,et al. NF-kappaB-dependent induction of microRNA miR-146,an inhibitor targeted to signaling proteins of innate immune responses[J]. Proc Natl Acad Sci USA,2006,103(33):12481-12486. doi: 10.1073/pnas.0605298103
    [17]
    Zeng Z,Gong H,Li Y,et al. Upregulation of miR-146a contributes to the suppression of inflammatory responses in LPS-induced acute lung injury[J]. Exp Lung Res,2013,39(7):275-282. doi: 10.3109/01902148.2013.808285
    [18]
    Gao M,Wang X,Zhang X,et al. Attenuation of cardiac dysfunction in polymicrobial sepsis by microRNA-146a is mediated via targeting of IRAK1 and TRAF6 expression[J]. J Immunol,2015,195(2):672-682. doi: 10.4049/jimmunol.1403155
    [19]
    Pundziute G,Schuijf J D,van Velzen J E,et al. Assessment with multi-slice computed tomography and gray-scale and virtual histology intravascular ultrasound of gender-specific differences in extent and composition of coronary atherosclerotic plaques in relation to age[J]. Am J Cardiol,2010,105(4):480-486. doi: 10.1016/j.amjcard.2009.09.054
    [20]
    Blaha M J,Nasir K,Rivera J J,et al. Gender differences in coronary plaque composition by coronary computed tomography angiography[J]. Coron Artery Dis,2009,20(8):506-512. doi: 10.1097/MCA.0b013e328331368d
  • Relative Articles

    [1] Shuangshuang XU, Wei ZHAO, Lei JIANG, Huajiang LIU, Fang WANG, Zhisheng TAN, Likun ZHOU. Correlation Between TyG Index,MHR and Coronary Lesions,Myocardial Ischemia in Patients with Coronary Heart Disease,and the Value of Combined Detection. Journal of Kunming Medical University, 2024, 45(3): 65-71.  doi: 10.12259/j.issn.2095-610X.S20240310
    [2] Wenqing MIAO, Yu WANG, Xiaoli ZHAO, Nini TIAN, Liying YOU. Analysis of Differential Gene Expression and Function in Peripheral Blood of Patients with Coronary Heart Disease and Acute Myocardial Infarction. Journal of Kunming Medical University, 2022, 43(6): 25-34.  doi: 10.12259/j.issn.2095-610X.S20220614
    [3] Jing TANG, Jun-chao HUANG, Ya-fei HUANG, Ming-zhu GENG, Xiao-qin MAO, Jian-ping PU. Application of Lipoprotein-associated Phospholipase A2 in Coronary Heart Disease Patients Taking Statins. Journal of Kunming Medical University, 2021, 42(12): 6-10.  doi: 10.12259/j.issn.2095-610X.S20211205
    [4] Bin LIU, Xian-gang LI, Min ZHANG, Fang ZHOU, Ren-hua LIN, Jie YANG, Liang ZHANG, Xian-kun WANG, Ya-nan PAN. Main Influencing Factors of the Second Hospitalization of Patients with Coronary Heart Disease. Journal of Kunming Medical University, 2021, 42(6): 103-109.  doi: 10.12259/j.issn.2095-610X.S20210618
    [5] Dai Hai Long , Zhang Xing , Pan Yun , Feng Xiao Lan , Lu Xiang Ting , Guang Xue Feng , Yin Xiao Long . . Journal of Kunming Medical University, 2020, 41(04): 60-63.
    [6] Wang Ji Yan , Duan Yong . . Journal of Kunming Medical University, 2018, 39(12): 1-4.
    [7] Ye Xue Qun , Nie Lei . . Journal of Kunming Medical University, 2017, 38(02): 95-98.
    [8] Li Lin , Li Ji Yi , Wang De Zhao , Liu Wei . 武汉地区123例冠心病患者CYP2C19基因多态性分布. Journal of Kunming Medical University, 2017, 38(06): 60-63.
    [9] Xiao Yi . The Clinical Effect of CDSP Treatment for Coronary Heart Disease. Journal of Kunming Medical University,
    [10] Li Wen Hua , Wei Yun Hong , Ye Ji Yun . Effect of Probiotics on Blood Lipid Metabolism of Elderly Patients with Coronary Heart Disease. Journal of Kunming Medical University, 2016, 37(12): 82-84.
    [11] Dai Qing Yuan . . Journal of Kunming Medical University,
    [12] Feng Yong Hong . . Journal of Kunming Medical University,
    [13] Zhou Kai Hua . . Journal of Kunming Medical University,
    [14] Tan Xiao Bing . . Journal of Kunming Medical University,
    [15] Li Hong Dao . . Journal of Kunming Medical University,
    [16] Yang Ping . . Journal of Kunming Medical University,
    [17] Zhu Ya Juan . . Journal of Kunming Medical University,
    [18] Yu Mei . . Journal of Kunming Medical University,
    [19] Yin Lin . . Journal of Kunming Medical University,
    [20] Lv Han Xian . Detection of Periodontopathogens in Subgingival Plaque of Patients with Coronary Heart Disease and Periodontitis. Journal of Kunming Medical University,
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)  / Tables(3)

    Article Metrics

    Article views (2870) PDF downloads(14) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return