Expression of Serum H-FABP， Platelet Activating Factor and IMA in Patients with Coronary Heart Disease and Its Clinical Implications

Ju TIAN; Wen-jie WANG; Qian LI

doi:10.12259/j.issn.2095-610X.S20201216

Volume 41 Issue 12

Dec. 2019

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Article Navigation > Journal of Kunming Medical University > 2020 > 41(12): 49-54

Ju TIAN, Wen-jie WANG, Qian LI. Expression of Serum H-FABP， Platelet Activating Factor and IMA in Patients with Coronary Heart Disease and Its Clinical Implications[J]. Journal of Kunming Medical University, 2020, 41(12): 49-54. doi: 10.12259/j.issn.2095-610X.S20201216

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Ju TIAN, Wen-jie WANG, Qian LI. Expression of Serum H-FABP， Platelet Activating Factor and IMA in Patients with Coronary Heart Disease and Its Clinical Implications[J]. Journal of Kunming Medical University, 2020, 41(12): 49-54. doi: 10.12259/j.issn.2095-610X.S20201216

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Expression of Serum H-FABP， Platelet Activating Factor and IMA in Patients with Coronary Heart Disease and Its Clinical Implications

doi: 10.12259/j.issn.2095-610X.S20201216

Ju TIAN¹,
Wen-jie WANG^{1
,
,},
Qian LI²

1.
Dept. of Functional Inspection，Qingdao 8th People’s Hospital Qingdao Shandong
2.
Dept. of Gastroenterology，Affiliated Hospital of Qingdao University，Qingdao Shandong 266000 ，China

Received Date: 2020-04-16
Publish Date: 2019-12-26

Abstract

Abstract

Objective To investigate the expression of serum H-FABP, platelet activating factor （PAF） and ischemia-modified albumin （IMA） in patients with coronary heart disease and its clinical implications. Methods 168 patients who reported chest pain and underwent coronary angiography in Qingdao 8th People's Hospital from April 2017 to October 2019 were enrolled as subjects. Based on the results of coronary angiography, subjects were divided into control group （n = 30）, SAP group （n = 55）, UAP group （n = 51） and AIM group （n = 32）. Serum H-FABP, PAF and IMA levels in each group were compared. Influencing factors of coronary heart disease were analyzed by multivariate logistic regression. The correlation between GRACE score and serum H-FABP, PAF and IMA levels was analyzed by Pearson method. The receiver operating Characteristic curve （ROC） was used to analyze the diagnostic value of each indicator for coronary heart disease. Results GRACE score and serum H-FABP, PAF and IMA levels were the highest in AMI group, followed by UAP group, SAP group, and control group （P < 0.05）. GRACE scores and serum H-FABP, PAF, and IMA levels were independent risk factors for coronary heart disease （ OR = 1.993, 2.325, 1.741, and 2.208, P < 0.05）. GRACE score was positively correlated with serum H-FABP, PAF and IMA levels （ r = 0.9023, 0.8967 and 0.9364, P < 0.05）. In diagnosing coronary heart disease, the diagnostic value of serum H-FABP, PAF and IMA combined was significantly higher than that of each indicator alone. Conclusion Elevated serum H-FABP, PAF and IMA levels are major risk factors for coronary heart disease, and serum H-FABP, PAF and IMA levels are positively correlated with GRACE scores. Detection of serum H-FABP, PAF and IMA combined are of value in the clinical diagnosis of coronary heart disease.
- H-FABP,
- Platelet activating factor,
- Ischemic modified albumin,
- Coronary angiography,
- GRACE score

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References(24)

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