Effects of Dexmedetomidine on Respiration in Postoperative Patients Undergone General Anesthesia at High Altitude Areas

Qing-qing XIONG; Xiao-dong LUO; Bu-fang FU; Jia-yi ZHONG; Guo-lian HE

doi:10.12259/j.issn.2095-610X.S20201224

Volume 41 Issue 12

Dec. 2019

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2020 > 41(12): 85-88

Qing-qing XIONG, Xiao-dong LUO, Bu-fang FU, Jia-yi ZHONG, Guo-lian HE. Effects of Dexmedetomidine on Respiration in Postoperative Patients Undergone General Anesthesia at High Altitude Areas[J]. Journal of Kunming Medical University, 2020, 41(12): 85-88. doi: 10.12259/j.issn.2095-610X.S20201224

Citation:

Qing-qing XIONG, Xiao-dong LUO, Bu-fang FU, Jia-yi ZHONG, Guo-lian HE. Effects of Dexmedetomidine on Respiration in Postoperative Patients Undergone General Anesthesia at High Altitude Areas[J]. Journal of Kunming Medical University, 2020, 41(12): 85-88. doi: 10.12259/j.issn.2095-610X.S20201224

Citation:

Qing-qing XIONG, Xiao-dong LUO, Bu-fang FU, Jia-yi ZHONG, Guo-lian HE. Effects of Dexmedetomidine on Respiration in Postoperative Patients Undergone General Anesthesia at High Altitude Areas[J]. Journal of Kunming Medical University, 2020, 41(12): 85-88. doi: 10.12259/j.issn.2095-610X.S20201224

PDF( 540 KB)

Effects of Dexmedetomidine on Respiration in Postoperative Patients Undergone General Anesthesia at High Altitude Areas

doi: 10.12259/j.issn.2095-610X.S20201224

Dept. of Anesthesiology，Lijiang People’s Hospital，Lijiang Yunnan 674100，China

Received Date: 2020-03-26
Publish Date: 2019-12-26

Abstract

Abstract

Objective To observe the effect of dexmedetomidine on respiration in postoperative patients undergone general anesthesia at high altitude areas. Methods 60 patients who received laparoscopic cholecystectomy under tracheal general anesthesia, and all the patients had been living in high altitude area (altitude: 2000 m～3000 m) for at least one year. The patients were randomly assigned into two groups. The dexmedetomidine group received a 10-minute- infusion of dexmedetomidine 0.6 μg/kg, while the control group was given a volume-matched normal saline in same dose. After operation, the tracheal tube was removed and then oxygen 3 L/min was given. A rapid arterial blood gas examination was performed one hour after operation. At the time points of 1 hour, 3 hours, 6 hours and 12 hours after operation, we examined the blood oxygen saturation and the respiratory rate, and recorded the number of patients with hypoxemia in both groups (Hypoxemia was considered to be present when blood oxygen saturation was ≤ 85%). Results The oxygen partial pressure at each postoperative point in both groups was higher than that before surgery (P < 0.05), and there was no statistically significant difference in oxygen partial pressure at each postoperative point in the two groups ( P > 0.05). Oxygen saturation at each time point after operation in both groups was higher than that before operation ( P < 0.05), and oxygen saturation at 3 h after operation in the dexmedetomidine group was lower than that in the control group ( P < 0.05). The respiration rate of the dexmedetomidine group at 1 h, 3 h and 12 h after operation was lower than that of the control group ( P < 0.05). No oxygen saturation below 85% was found in both groups after operation. Conclusion The administration of dexmedetomidine to patients under tracheal general anesthesia at high altitude areas will reduce the number of breaths and blood oxygen saturation at some time points, but it will not reduce the partial pressure of oxygen at 1 min after surgery, and will not cause postoperative hypoxemia.
- Dexmedetomidine,
- High altitude areas,
- General anesthesia,
- Respiration

FullText(HTML)

References(15)

References

[1]	李爽, 兰德, 魏雪梅. 高原环境与睡眠呼吸改变的研究现状[J].西南军医,2011,13(5):903-905. doi: 10.3969/j.issn.1672-7193.2011.05.064
[2]	仁增拉姆. 高原人群血氧饱和度调查[J].西藏: 西藏医药杂志,2009,30(04):4.
[3]	陈志刚, 李金宝, 吕欣. 全身麻醉的肺损伤及其保护策略[J].上海医学,2016,039(002):121-124.
[4]	曹洪森. 高原地区全身麻醉行腹部手术对呼吸的影响及处理[J].中国现代医生,2009,47(14):92-93.
[5]	尹文亮,李泽文,任雨笙. 高原地区创伤患者手术的麻醉体会[J].第二军医大学学报,2001,22(2):181-184.
[6]	韩武斌, 赵书哲, 冯国君. 高原地区全麻拔管后22 例血氧饱和度的临床观察[J].高原医学,2003,13(1):56-57.
[7]	俞文军, 宋有成. 高海拔地区腹腔镜胆囊切除术麻醉及围术期SpO₂观察[J].青海医药杂志,1996,26(5):11-12.
[8]	李彤. 右美托咪定在腹腔镜手术中的临床应用研究[J].当代医学,2017,23(1):75-76.
[9]	强铭. 右美托咪啶用于全身麻醉临床观察[J].中国医学工程,2016,24(1):78-79.
[10]	Ebert T J, Hall J E, Barney J A, et al. The effects of increasing plasma concentrations of dexmedetomidine in humans[J]. Anesthesiology,2000,93(2):382-394. doi: 10.1097/00000542-200008000-00016
[11]	Hall J E , Uhrich T D , Barney J A , et al. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions[J]. Anesthesia & Analgesia,2000,90(3):699-705.
[12]	乔飞, 李轩, 衡新华. 右美托咪定在气管插管中对循环系统及丙泊酚用量的影响[J].昆明医科大学学报,2011,32(7):130-133.
[13]	黄鹏健. 右美托咪啶对术后复苏患者的呼吸系统影响[J].吉林医学,2015,36(14):982.
[14]	钟真良. 右美托咪定对腹部手术患者全身麻醉苏醒期呼吸, 血流动力学, BIS值的影响[J].职业卫生与病伤,2016,31(2):111-115.
[15]	谢小伟, 李武军, 赵海, 等. 不同吸氧流量对高海拔高原地区病人术后血氧饱和度的影响[J].外科理论与实践,2019,24(2):155-158.

Relative Articles(20)

Relative Articles

[1]	Hongmei BAO, Rong QIN, Yu ZHANG, Meiju YANG, Gang SU. Effect of PCV-VG Mode Combined with Dexmedetomidine on Intraoperative Respiratory Mechanics and Blood Gas Indicators in Patients Undergoing Laparoscopic Sleeve Gastrectomy. Journal of Kunming Medical University, 2024, 45(9): 110-115. doi: 10.12259/j.issn.2095-610X.S20240917
[2]	Xin DU, Chao SONG, Bing DU, Xuechang WANG, Lian DUAN. Analysis of Serum 25-Hydroxyvitamin D Levels in Population with Lumbar Disc Herniation in High-Altitude Areas. Journal of Kunming Medical University, 2023, 44(): 1-7. doi: 10.12259/j.issn.2095-610X.S20230813
[3]	Rong QIN, Gang SU, Yu ZHANG, Wei YIN, zhen ZHAO. Effect of Dolisetron Mesylate Combined with Dexmedetomidine on Plasma Motilin and Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Sleeve Gastrectomy. Journal of Kunming Medical University, 2023, 44(2): 156-160. doi: 10.12259/j.issn.2095-610X.S20230215
[4]	Yue LU, Changming QIU, Yunli YANG, Zhiguo HUANG, Zhigui LI, Weiqing MA, Na LI. Analgesia of Ultrasound-guided Single-dose Adductor Canal Block with Dexmedetomidine Combined with Ropivacaine after Patella Fracture Surgery in Adults. Journal of Kunming Medical University, 2022, 43(6): 68-73. doi: 10.12259/j.issn.2095-610X.S20220613
[5]	Yuan YANG, Li-jia PENG, Lan-qing PU, Jun-jie LI, Jian-lin SHAO, Xin YANG. Application of Propofol Combined with Dexmedetomidine or Midazolam in Painless Gastrointestinal Endoscopy in the Elderly. Journal of Kunming Medical University, 2021, 42(2): 43-48. doi: 10.12259/j.issn.2095-610X.S20210221
[6]	Li-jia PENG, Yuan YANG, Ran GUO, Li XIONG, Jun-jie LI, Jian-lin SHAO, Wei-jun ZENG. Effect of Dexmedetomidine Combined with Nalbuphine in Meningioma Surgery on Postoperative Cognitive Function. Journal of Kunming Medical University, 2021, 42(3): 18-22. doi: 10.12259/j.issn.2095-610X.S20210306
[7]	Yun-rui GUO, Jian-ming YANG, Hao YANG, Ye-cai ZHANG, Guo-yun ZHANG, Chen ZHOU, Ya-ting HOU. The Clinical Study on the Effects of Sedation，Analgesia and Slow Induction of Endotracheal Intubation on Hemodynamics，Reduction of Postoperative Adverse Memory and Psycho-psychological Effects in Patients with General Anesthesia. Journal of Kunming Medical University, 2021, 42(9): 127-133. doi: 10.12259/j.issn.2095-610X.S20210906
[8]	Liu YANG, Qi-cai QU, Rui CHEN, Shu-lan JIAO, Yong-yu SI, Hua ZHOU. Effects of Dexmedetomidine on Inflammatory Response in Rats with Smoke Inhalation Lung Injury. Journal of Kunming Medical University, 2020, 41(11): 30-37. doi: 10.12259/j.issn.2095-610X.S20201124
[9]	Mai-qiao YANG, Fu-rong ZHANG, Li-li LIU, Xiao-ying LIU, ping LIU. Clinical Effect of Dexmedetomidine on Shivering Reaction in Cesarean Section Patients during Combined Spinal-epidural Anesthesia. Journal of Kunming Medical University, 2020, 41(11): 98-102. doi: 10.12259/j.issn.2095-610X.S20201125
[10]	Wang Gang , Zhang Lei , Zhou Juan , Guo Tao . . Journal of Kunming Medical University, 2019, 40(09): 106-109.
[11]	Yang Yue, Tao Jian Ping . . Journal of Kunming Medical University, 2019, 40(12): 135-139.
[12]	Shi Shao Feng , Su Gang , Peng Bo , Zhang Yu . Effects of Different Anesthetic Methods on Parturient and Fetus with Cesarean Section due to Placenta Previa. Journal of Kunming Medical University, 2018, 39(07): 72-75.
[13]	Li Zheng Chao , Qian Chuan Yun , Wu Hai Ying , Zhang Wei , Xia Jing . Effect of Dexmedetomidine on Brain Edema in Rats with Severe Traumatic Brain Injury. Journal of Kunming Medical University, 2017, 38(11): 40-44.
[14]	Song Shi Qin . Influence of Dexmedetomidine on the Oxygenation and Cardio-pulmonary Function of Elderly Patients with Surgery. Journal of Kunming Medical University, 2017, 38(07): 122-125.
[15]	Li Wen Feng , Fan Xiao Hua , Dong Fa Tuan , Li Na . . Journal of Kunming Medical University, 2017, 38(02): 118-121.
[16]	Li Zhi Gui . . Journal of Kunming Medical University,
[17]	Li Zhi Gui . . Journal of Kunming Medical University,
[18]	Dan Ke Ji . . Journal of Kunming Medical University,
[19]	Ma Liang . . Journal of Kunming Medical University,
[20]	Qi Lei . . Journal of Kunming Medical University,