Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol

Wei-jia ZHAO; Hong-bin LI; Zong-han CHEN

doi:10.12259/j.issn.2095-610X.S20201227

Volume 41 Issue 12

Dec. 2019

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Article Navigation > Journal of Kunming Medical University > 2020 > 41(12): 99-103

Wei-jia ZHAO, Hong-bin LI, Zong-han CHEN. Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol[J]. Journal of Kunming Medical University, 2020, 41(12): 99-103. doi: 10.12259/j.issn.2095-610X.S20201227

Citation:

Wei-jia ZHAO, Hong-bin LI, Zong-han CHEN. Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol[J]. Journal of Kunming Medical University, 2020, 41(12): 99-103. doi: 10.12259/j.issn.2095-610X.S20201227

Citation:

Wei-jia ZHAO, Hong-bin LI, Zong-han CHEN. Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol[J]. Journal of Kunming Medical University, 2020, 41(12): 99-103. doi: 10.12259/j.issn.2095-610X.S20201227

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Evaluation of Peripheral Blood Cytokine Levels before and after Psoriasis Treatment with Narrow-spectrum UVB Combined with Carpotriol

doi: 10.12259/j.issn.2095-610X.S20201227

1.
Dept. of Dermatology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan， 650032
2.
Higher Education Research and Evaluation Center，Yunnan University of Traditional Chinese Medicine，Kunming Yunnan 650500，China

Received Date: 2020-06-23
Publish Date: 2020-12-25

Abstract

Abstract

Objective To analyze the clinical efficacy of narrow-spectrum UVB in the treatment of psoriasis and the effect on peripheral blood cytokines. Methods 109 patients with psoriasis treated in the First Affiliated Hospital of Kunming Medical University from May 2018 to March 2020 were selected and randomly divided into experimental group（n = 55）and control group（n = 54）. The control group was treated with capotriol ointment, and the experimental group was treated with narrow-spectrum UVB combined with capotriol ointment. The clinical efficacy and the changes of cytokines in peripheral blood of patients in the two groups were compared. Results The total effective rate of clinical treatment in the experimental group was higher than that of control group, and the difference was statistically significant（P < 0.05）. After treatment, Th17, Treg and Th17/Treg in the experimental group were statistically significant in control group（ P < 0.05）. After treatment, TNF- radiation and il-10 in the experimental group were compared with those in the control group, and the difference was statistically significant（ P < 0.05）. Conclusion Narrow spectrum UVB treatment of psoriasis can improve the clinical outcomes, which may be related to the inhibition of serum TNF- beam and Th17 levels in patients with psoriasis, and the improvement of 1l-10 and Treg cell levels. UVB in narrow spectrum may play a role in improving Th17/Treg imbalance ratio and cytokine levels in patients with psoriasis, which has great potential in clinical practice.
- Narrow spectrum,
- UVB rays,
- Carpotriol,
- Psoriasis,
- Clinical outcome,
- Cytokines

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