Molecular Epidemiology of Human Rhinovirus in 2 260 Children with Acute Lower Respiratory Tract Infection

Li TAN; Ming LI; Yu-xing SUN; Zhen ZHANG; Zheng-yan GAN

doi:10.12259/j.issn.2095-610X.S20201233

Volume 41 Issue 12

Dec. 2019

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2020 > 41(12): 119-122

Li TAN, Ming LI, Yu-xing SUN, Zhen ZHANG, Zheng-yan GAN. Molecular Epidemiology of Human Rhinovirus in 2 260 Children with Acute Lower Respiratory Tract Infection[J]. Journal of Kunming Medical University, 2020, 41(12): 119-122. doi: 10.12259/j.issn.2095-610X.S20201233

Citation:

Li TAN, Ming LI, Yu-xing SUN, Zhen ZHANG, Zheng-yan GAN. Molecular Epidemiology of Human Rhinovirus in 2 260 Children with Acute Lower Respiratory Tract Infection[J]. Journal of Kunming Medical University, 2020, 41(12): 119-122. doi: 10.12259/j.issn.2095-610X.S20201233

Citation:

PDF( 551 KB)

Molecular Epidemiology of Human Rhinovirus in 2 260 Children with Acute Lower Respiratory Tract Infection

doi: 10.12259/j.issn.2095-610X.S20201233

Li TAN^{1, 2},
Ming LI^{1, 2},
Yu-xing SUN^{1, 2},
Zhen ZHANG^{1, 2},
Zheng-yan GAN^{1, 2
,
,}

1.
Dept. of Respiratory Medicine，Kunming Children’s Hospital
2.
Dept. of Respiratory Medicine，Children’s Hospital Affiliated to Kunming Medical University， Kunming Yunnan 650228，China

Received Date: 2020-05-22
Publish Date: 2019-12-26

Abstract

Abstract

Objective To investigate the molecular epidemiological characteristics of human rhinovirus (HRV) infection in hospitalized children with acute lower respiratory tract infection (ALRTI) in Kunming. Methods A total of 2260 children with ALRTI who were hospitalized in Kunming children's Hospital from January 2019 to December 2019 were selected. HRV was detected by reverse transcription polymerase chain reaction (RT-PCR) in nasopharyngeal aspirates or sputum. 40 HRV positive samples were randomly selected to amplify VP4 / VP2 gene fragment, and the amplified products were sequenced and their types were identified. Results The positive rate of HRV was 6.50% (147 / 2260). There was no significant difference in HRV positive rate among different age groups (χ² = 3.240, P = 0.356). The positive rate of HRV in children with ALRTI was significantly different in different seasons, the peak is in summer, followed by autumn (χ² = 37.674, P < 0.05). Among the 40 positive samples, 23 were HRV-A, 5 were HRV-B and 12 were HRV-C. There was no significant difference in fever and cough between HRV positive and HRV negative children ( P > 0.05), but there was significant difference in wheezing ( P < 0.05). Conclusion HRV is one of the pathogens of acute lower respiratory tract infection in Kunming area. The epidemic season is summer and autumn and HRV-A is the main type. Children infected with HRV are more likely to have wheezing.
- Rhinovirus,
- Respiratory tract infection,
- Children,
- Epidemiology

FullText(HTML)

References(19)

References

[1]	Royston L,Tapparel C. Rhinoviruses and Respiratory Enteroviruses:Not as Simple as ABC[J]. Viruses,2016,8(1):E16. doi: 10.3390/v8010016
[2]	江载芳, 申昆玲, 沈颖. 诸福棠实用儿科学[M]. 第8版, 北京: 人民卫生出版社, 2015: 1247-1253.
[3]	Wisdom A,Leitch E C,Gaunt E,et al. Screening respiratory samples for detection of human rhinoviruses (HRVs) and enteroviruses:Comprehensive VP4-VP2 typing reveals high incidence and genetic diversity of HRV species C[J]. J Clin Microbiol,2009,47(12):3958-3967. doi: 10.1128/JCM.00993-09
[4]	Harvala H,Simmonds P. Human parechoviruses:Biology,Epidemiology and clinical significance[J]. J Clin Virol,2009,45(1):1-9. doi: 10.1016/j.jcv.2009.03.009
[5]	Costa L F,Queiróz D A,Lopes da Silveira H,et al. Human rhinovirus and disease severity in children[J]. Pediatrics,2014,133(2):e312-321. doi: 10.1542/peds.2013-2216
[6]	Hartiala M,Lahti E,Forsström V,et al. Characteristics of hospitalized rhinovirus-associated community-acquired pneumonia in children,finland,2003-2014[J]. Front Med (Lausanne),2019,6:235. doi: 10.3389/fmed.2019.00235
[7]	Spichak T V,Yatsyshina S B,Кatosova L К,et al. Is the role of rhinoviruses as causative agents of pediatric community-acquired pneumonia over-estimated?[J]. Eur J Pediatr,2016,175(12):1951-1958. doi: 10.1007/s00431-016-2791-x
[8]	Liu G S,Li H,Zhao S C,et al. Viral and bacterial etiology of acute febrile respiratory syndrome among patients in qinghai,China[J]. Biomed Environ Sci,2019,32(6):438-445.
[9]	Zhao Y,Lu R,Shen J,et al. Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai,China[J]. BMC Infect Dis,2019,19(1):729. doi: 10.1186/s12879-019-4385-5
[10]	赵梦川,吴勇,黄迎彬,等. 河北省重症肺炎患儿非细菌性呼吸道病原学研究[J].河北医药,2020,42(5):774-778. doi: 10.3969/j.issn.1002-7386.2020.05.033
[11]	Freymuth F,Vabret A,Dina J,et al. Bronchiolitis viruses[J]. Arch Pediatr,2010,17(8):1192-201. doi: 10.1016/j.arcped.2010.05.006
[12]	Miller E K,Lu X,Erdman D D,et al. Rhinovirus-associated hospitalizations in young children[J]. J Infect Dis,2007,195(6):773-781. doi: 10.1086/511821
[13]	Wang W,Cavailler P,Ren P,et al. Molecular monitoring of causative viruses in child acute respiratory infection in endemo-epidemic situations in Shanghai[J]. J Clin Virol,2010,49(3):211-218. doi: 10.1016/j.jcv.2010.08.005
[14]	Jin Y,Yuan X H,Xie Z P,et al. Prevalence and clinical characterization of a newly identified human rhinovirus C species in children with acute respiratory tract infections[J]. J Clin Microbiol,2009,47(9):2895-900. doi: 10.1128/JCM.00745-09
[15]	Lu Q B,Wo Y,Wang L Y,et al. Molecular epidemiology of human rhinovirus in children with acute respiratory diseases in Chongqing,China[J]. Sci Rep,2014,4:6686.
[16]	Piralla A,Baldanti F,Gerna G. Phylogenetic patterns of human respiratory picornavirus species,including the newly identified group C rhinoviruses,during a 1-year surveillance of a hospitalized patient population in Italy[J]. J Clin Microbiol,2011,49(1):373-376. doi: 10.1128/JCM.01814-10
[17]	Erkkola R,Turunen R,Risnen K,et al. Rhinovirus C is associated with severe wheezing and febrile respiratory illness in young children[J]. Pediatr Infect Dis J,2020,39(4):283-286. doi: 10.1097/INF.0000000000002570
[18]	Psarras S,Volonaki E,Skevaki C L,et al. Vascular endothelial growth factor-mediated induction of angiogenesis by human rhinoviruses[J]. J Allergy Clin Immunol,2006,117(2):291-297. doi: 10.1016/j.jaci.2005.11.005
[19]	Brownlee J W,Turner R B. New developments in the epidemiology and clinical spectrum of rhinovirus infections[J]. Curr Opin Pediatr,2008,20(1):67-71. doi: 10.1097/MOP.0b013e3282f41cb6

Relative Articles(20)

Relative Articles

[1]	Yanjuan CHEN, Wanrong LUO, Ruixue MA, Yilin DAI, Guixian LI, Yunfen TIAN. Clinical Analysis of the Spectrum of Upper Gastrointestinal Diseases in 424 Cases of Children in A Tertiary Hospital in Kunming. Journal of Kunming Medical University, 2024, 46(): 1-6.
[2]	Ruoyu WANG, Wei CHEN, Xun XU, Wende CAO, Yulan MIAO. Epidemiological Investigation and Risk Factors Analysis of Systemic Inflammatory Response Syndrome in 329 Children with Burn. Journal of Kunming Medical University, 2024, 45(5): 123-129. doi: 10.12259/j.issn.2095-610X.S20240519
[3]	Xuelin ZHANG, Lu LIU, Yanzhi CHEN, Caijun ZHA, Yanli LI. The Distribution and Drug Resistance of Pathogenic Bacteria in Respiratory Tract Infections in Children from 2019 to 2022. Journal of Kunming Medical University, 2024, 45(1): 149-155. doi: 10.12259/j.issn.2095-610X.S20240125
[4]	Weijie LI, Liqin CHEN, Yaling LI, Yonghui HAN, Xiaojuan LI, Ruogu WANG. Epidemiology of CRKP Infection Outbreak in a Neonatal Intensive Care Unit. Journal of Kunming Medical University, 2023, 44(12): 144-149. doi: 10.12259/j.issn.2095-610X.S20231223
[5]	Xiaoli SHANG, Junxue NI, Yeying WANG, Jiao SHAN, Na BAI, Song WANG. Clinical Epidemiological Characteristics of Mycoplasma Pneumoniae and Its Correlation with Climatic Environment. Journal of Kunming Medical University, 2023, 44(6): 97-101. doi: 10.12259/j.issn.2095-610X.S20230618
[6]	Shuangshuang WANG, Liqin CHEN, Yaling LI, Weijie LI, Jiayi YANG. Analysis of Epidemiological Characteristics of Neonatal Rotavirus Infection from 2020 to 2022. Journal of Kunming Medical University, 2023, 44(5): 26-31. doi: 10.12259/j.issn.2095-610X.S20230509
[7]	Ying ZHANG, Hong GAO, Cuixiang ZHANG, Zeying CHEN, Hongqun ZOU, Liqiong LI, Jupin YANG, Yuexin HU. Helicobacter Pylori Infection in Children and its Correlation with Iron Deficiency Anemia. Journal of Kunming Medical University, 2022, 43(4): 103-106. doi: 10.12259/j.issn.2095-610X.S20220418
[8]	Liqin CHEN, Yaling LI, Xiaojuan LI, Yonghui HAN, Weijie LI. Epidemiological Analysis of Clinical Isolation of Multi-drug Resistant Bacteria in Children’ s Hospitals. Journal of Kunming Medical University, 2022, 43(1): 40-47. doi: 10.12259/j.issn.2095-610X.S20220105
[9]	Hai-lin HUANG, Xiao-juan LI, Jian-wen YIN, Hong-chao JIANG. Distribution and Drug Sensitivity of Salmonella and Shigella in Children with Infectious Diarrhea in Kunming from 2017 to 2020. Journal of Kunming Medical University, 2021, 42(7): 83-87. doi: 10.12259/j.issn.2095-610X.S20210713
[10]	Song-tao BIN, Cheng-qing WU, Li TAN, Rui HAO, Ming LI, Xia ZHANG. Etiology，Diagnosis and Treatment of 84 Children with Central Airway Stenosis. Journal of Kunming Medical University, 2021, 42(12): 123-128. doi: 10.12259/j.issn.2095-610X.S20211231
[11]	Jin-yan ZU, Fan LOU, Cheng MING, guo LI, Ying-qin GAO, Jing MA. Assessment of Nasal Resistance Measurement in the Diagnosis and Treatment of OSA in Children. Journal of Kunming Medical University, 2021, 42(12): 101-105. doi: 10.12259/j.issn.2095-610X.S20211227
[12]	Li Yan Hong , Zhang Xian , Zhang Jun Tao , Zhao Meng Ru , Tang Jia Hui , Li Lin Xia . . Journal of Kunming Medical University, 2018, 39(11): 67-73.
[13]	Chen Jing Yi , Liao Fei , Feng Lei , Chu Cong Jia . Prevalence and Drug Resistance of Streptococcus Pneumoniae Infection in Children in Yuxi during from 2014 to 2016. Journal of Kunming Medical University, 2017, 38(11): 82-85.
[14]	Yang Jun Jun , Hu Xi Chi , Yan Zi He . . Journal of Kunming Medical University, 2017, 38(03): 119-122.
[15]	Qi Zhi Ye . Comparative Analysis of 2000~2010 Epidemiological Survey of Childhood Asthma in Kunming City， China. Journal of Kunming Medical University,
[16]	Sheng Xiao Cui . . Journal of Kunming Medical University,
[17]	Bai Zhi Yao . . Journal of Kunming Medical University,
[18]	He Cheng Lu . . Journal of Kunming Medical University,
[19]	Li Xiu Yun . . Journal of Kunming Medical University,
[20]	. Epidemiological Investigation of Asthma in Children Aged 0 ～ 14 Years Old in Yuxi City. Journal of Kunming Medical University,