Volume 41 Issue 12
Dec.  2019
Turn off MathJax
Article Contents
Chun-Xia HE, Zhi-Juan LIU, Li AI, Yong-Xia LI. Coagulation Function in Patients with Obstructive Sleep Apnea Hypopnea[J]. Journal of Kunming Medical University, 2020, 41(12): 123-127. doi: 10.12259/j.issn.2095-610X.S20201235
Citation: Chun-Xia HE, Zhi-Juan LIU, Li AI, Yong-Xia LI. Coagulation Function in Patients with Obstructive Sleep Apnea Hypopnea[J]. Journal of Kunming Medical University, 2020, 41(12): 123-127. doi: 10.12259/j.issn.2095-610X.S20201235

Coagulation Function in Patients with Obstructive Sleep Apnea Hypopnea

doi: 10.12259/j.issn.2095-610X.S20201235
  • Received Date: 2020-05-10
  • Publish Date: 2019-12-26
  •   Objective   To investigate the correlation between OSA with different severity and coagulation function and sleep respiratory monitoring index by detecting the level of coagulation function in OSA patients with different severity.   Methods   A total of 184 patients undergoing sleep breathing monitoring in the Department of Respiratory Medicine of the Second Affiliated Hospital of Kunming Medical University from January 2018 to January 2020 were selected. According to apnea Hypopnea index(AHI), patients were divided into 3 groups, including 50 patients in the normal control group(group A), 45 patients in the mild OSA group(group B), and 86 patients in the moderate-severe OSA group(group C) . The differences of coagulation function indexes and sleep respiratory monitoring indexes in the normal control group, the mild OSA group and the moderate and severe OSA group were compared, and the correlation between coagulation function indexes and AHI, LSaO2 and LAT were analyzed.   Results   There were no statistically significant differences in APTT, INR, PTR, FIB, TT, d-dimer, AT and FDPs between group A, B and C(P > 0.05), no statistically significant differences in PT between group A and B( P > 0.05); The PT value of group C was significantly higher than that of group A and B( P < 0.05). Compared with group A and Group B, the AHI and LAT values of group C were significantly higher than those of group B and Group A, while those of group B were higher than those of group A. LSaO2 in group A and B was significantly different from that in group C; and FDPs of OSA group was negatively correlated with LSaO2(r = -0.157, P < 0.05). There was no significant difference in LSaO2 between group A and group B( P > 0.05); In OSA group, FDPs was negatively correlated with LSaO2(R = -0.157, P < 0.05).   Conclusion   PT prolonged among moderate-severe OSA patients, and FDPs is negatively correlated with LSaO2 in OSA patients, thus affecting coagulation function.
  • loading
  • [1]
    Benjafield A V, Ayas N T, Eastwood P R , et al.Estimation of the global prevalence and burden of obstructive sleep apnoea: A literature-based analysis.[J].Lancet Respir Med, 2019, 7(8):687-698
    [2]
    Seijo L M,Pérez-Warnisher M T,Giraldo-Cadavid L F,et al. Obstructive sleep apnea and nocturnal hypoxemia are associated with an increased risk of lung cancer[J]. Sleep Med,2019,63(11):41-45.
    [3]
    He Q,Zhang P,Li G,et al. The association between insomnia symptoms and risk of cardio-cerebral vascular events:A meta-analysis of prospective cohort studies[J]. Eur J Prev Cardiol,2017,24(10):1071-1082. doi: 10.1177/2047487317702043
    [4]
    Budhiraja R,Javaheri S,Parthasarathy S,et al. Incidence of hypertension in obstructive sleep apnea using hypopneas defined by a 3 percent oxygen desaturation or arousal but not by only 4 percent oxygen desaturation[J]. J Clin Sleep Med,2020,16(4):104-110.
    [5]
    Khaire S S,Gada J V,Utpat K V,et al. A study of glycemic variability in patients with type 2 diabetes mellitus with obstructive sleep apnea syndrome using a continuous glucose monitoring system[J]. Clin Diabetes Endocrinol,2020,6(10):10.
    [6]
    中国医师协会睡眠医学专业委员会. 成人阻塞性睡眠呼吸暂停多学科诊疗指南[J].中华医学杂志,2018,98(24):1092-1014.
    [7]
    莫晓云,刘建红,谢宇萍,等. 阻塞性睡眠呼吸暂停低通气综合征合并高血压的特点及危险因素[J].中华医学杂志,2016,96(4):605-609.
    [8]
    何权瀛,赵忠新. 提高我国阻塞性睡眠呼吸暂停相关卒中的防控水平[J].中华内科杂志,2014,53(8):596-597. doi: 10.3760/cma.j.issn.0578-1426.2014.08.003
    [9]
    王伊梦. 阻塞性睡眠呼吸暂停低通气综合征与凝血功能相关性分析[D].延吉: 延边大学硕士论文, 2019.
    [10]
    王强. 阻塞性睡眠呼吸暂停低通气综合征患者血液流变学指标及D-二聚体抗凝血酶Ⅲ水平变化[J].实用医技志,2017,24(6):624-625.
    [11]
    斯琪. 成年人阻塞性睡眠呼吸暂停低通气综合征患者血液凝血相关指标的临床研究[D].南宁: 广西医科大学硕士论文, 2017.
    [12]
    樊冀闽,许丹凤,张祎祥. 阻塞性睡眠呼吸暂停低通气综合征患者血液高凝倾向的研究[J].实用医技杂志,2016,23(12):1269-1271.
    [13]
    闫宏,郝金奇,余艳琴. 不同程度阻塞性睡眠呼吸暂停低通气综合征男性患者血细胞参数、凝血指标分析[J].中国疗养医学,2016,25(11):1124-1126.
    [14]
    车娟,张鹏,李金玲,等. 阻塞性睡眠呼吸暂停低通气综合征患者的凝血功能观察[J].血栓与止血学,2015,21(2):109-110. doi: 10.3969/j.issn.1009-6213.2015.02.015
    [15]
    Toraldo D M,Peverini F,De Benedetto M,et al. Obstructive sleep apnea syndrome:Blood viscosity,Blood coagulation abnormalities,and early atherosclerosis[J]. Lung,2013,191(1):1-7. doi: 10.1007/s00408-012-9427-3
    [16]
    李蓉,杨爱荣,杨发满,等. 老年睡眠呼吸暂停低通气综合征患者血清HIF-1α、VEGF、hs-CRP、NT-proBNP的水平[J].中国老年学杂志,2015,35(23):6814-6815. doi: 10.3969/j.issn.1005-9202.2015.23.076
    [17]
    陈敬绵,李宗军,李培兰,等. 阻塞性睡眠呼吸暂停与脑卒中相关性的研究进展[J].中国康复理论与实践,2019,25(7):783-787.
    [18]
    郑爱芳,钟雪梅,李菲菲,等. 阻塞性睡眠呼吸暂停低通气综合征患者血清ADMA、ET-1、VWF水平及临床意义[J].临床肺科杂志,2019,24(12):2166-2170. doi: 10.3969/j.issn.1009-6663.2019.12.007
    [19]
    Lippi G,Mattiuzzi C,Franchini M. Sleep apnea and venous thromboembolism. A systematic review[J]. Thromb Haemost,2015,114(5):958-963.
  • Relative Articles

    [1] Zhongqiang ZHANG, Lili HU, Junli CHEN. Clinical Efficacy of Intrapleural Injection of Thrombin Combined with Drainage tube Suspension in the Treatment of Refractory Pneumothorax. Journal of Kunming Medical University, 2024, 45(2): 1-6.
    [2] Zhongqiang ZHANG, Lili HU, Junli CHEN. The Curative Effect of Intrathoracic Injection of Thrombin Combined with Drainage Tube Suspension in the Treatment of Refractory Pneumothorax. Journal of Kunming Medical University, 2024, 45(5): 164-169.  doi: 10.12259/j.issn.2095-610X.S20240525
    [3] Jinxi YUE, Linjun WAN, Ruiling ZHANG, Xiaoran ZHANG, Ouya LIU, Xiaofan YU, Qingqing HUANG, Zongfang REN. Clinical Significance of a Marker of Thrombin Activity-fibrin Monomer after Surgery. Journal of Kunming Medical University, 2023, 44(3): 87-91.  doi: 10.12259/j.issn.2095-610X.S20230325
    [4] Wen-hui DONG, Xu ZOU, Zhong GONG, Li-qin SU, Hui-ying LI, Han ZHANG. Feasibility Analysis of the NOSAS Score as A Screening Tool for Obstructive Sleep Apnea in the Physical Examination Population. Journal of Kunming Medical University, 2021, 42(5): 48-53.  doi: 10.12259/j.issn.2095-610X.S20210509
    [5] Fan XU, Fang-yuan GUO, Yan HE, Xiang-qun WEI. Clinical Analysis of Peripheral Blood Cells and Coagulation Function in Patients with Adenomyosis. Journal of Kunming Medical University, 2021, 42(11): 128-133.  doi: 10.12259/j.issn.2095-610X.S20211124
    [6] Lou Fan , Zhang Tie Song , Ma Jing , Lin Ken , Zhao Li Ping . . Journal of Kunming Medical University, 2020, 41(07): 94-98.
    [7] Li-xian YUAN, Hong-tao ZHANG, Rui LI, Kun-rui CHEN, Kun-qian CHEN, An-shu XU. Diagnostic Efficacy of Serum PIVKA-Ⅱ Detection in Primary Hepatocellular Carcinoma. Journal of Kunming Medical University, 2020, 41(12): 80-84.  doi: 10.12259/j.issn.2095-610X.S20201223
    [8] Li Kong Long , Chen Jing , Zhao Ling , Shu Jun Ran , Ke Ting Yu . . Journal of Kunming Medical University, 2019, 40(10): 89-94.
    [9] Wu Hai Ying , Cao Shou Ming , Shi Bin , Bai Zhong , Li Yong Xia . Chemerin in Obstructive Sleep Apnea-hypopnea Patients' Pharyngeal Fat Deposition. Journal of Kunming Medical University, 2018, 39(01): 77-80.
    [10] Zhang Yong Kang , Yang Yan , Li Guo Hui . Value of 128-slice CT in Evaluation of Obstructive Sleep Apnea Syndrome. Journal of Kunming Medical University, 2017, 38(01): 57-60.
    [11] Fan Min Juan . . Journal of Kunming Medical University,
    [12] Zhang Chan . . Journal of Kunming Medical University,
    [13] Yang Xiao Ling . . Journal of Kunming Medical University,
    [14] Ke Ting Yu . . Journal of Kunming Medical University,
    [15] Feng Qing . . Journal of Kunming Medical University,
    [16] Miao Yu Lan . . Journal of Kunming Medical University,
    [17] Yan Xiao Hong . . Journal of Kunming Medical University,
    [18] Wang Hui Ming . . Journal of Kunming Medical University,
    [19] Miao Yu Lan . . Journal of Kunming Medical University,
    [20] . . Journal of Kunming Medical University,
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(4)

    Article Metrics

    Article views (2566) PDF downloads(20) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return