Clinical Features of Rhupus Syndrome

Jin-yun CAI; Juan WANG; Rui-xi SUN; Ping FU

doi:10.12259/j.issn.2095-610X.S20210201

Volume 42 Issue 2

Mar. 2021

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Jin-yun CAI, Juan WANG, Rui-xi SUN, Ping FU. Clinical Features of Rhupus Syndrome[J]. Journal of Kunming Medical University, 2021, 42(2): 64-69. doi: 10.12259/j.issn.2095-610X.S20210201

Citation:

Jin-yun CAI, Juan WANG, Rui-xi SUN, Ping FU. Clinical Features of Rhupus Syndrome[J]. Journal of Kunming Medical University, 2021, 42(2): 64-69. doi: 10.12259/j.issn.2095-610X.S20210201

Jin-yun CAI, Juan WANG, Rui-xi SUN, Ping FU. Clinical Features of Rhupus Syndrome[J]. Journal of Kunming Medical University, 2021, 42(2): 64-69. doi: 10.12259/j.issn.2095-610X.S20210201

Citation:

Jin-yun CAI, Juan WANG, Rui-xi SUN, Ping FU. Clinical Features of Rhupus Syndrome[J]. Journal of Kunming Medical University, 2021, 42(2): 64-69. doi: 10.12259/j.issn.2095-610X.S20210201

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Clinical Features of Rhupus Syndrome

doi: 10.12259/j.issn.2095-610X.S20210201

Dept. of Rheumatology，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2020-11-26
Publish Date: 2021-03-05

Abstract

Abstract

Objective To analyse the clinical features of Rhupus syndrome. Methods The medical records of 21 Rhupus syndrome patients who were admitted to the Second Affiliated Hospital of Kunming Medical University from 2015 to 2019 were analysed retrospectively. One hundred and twenty RA patients and 45 SLE patients from our Unit were randomly selected as the controls. The data of patients in the three groups were compared. Results Twenty-one patients with Rhupus syndrome were female, 61.9% patients were initiallypresented with RA. The age of onset was significantly younger than that of RA （P < 0.05）, but similar to that of SLE. Rhupus patients had longer diseaseduration than control groups.As compared with RA patients, Rhupus patients had higher incidence of bone erosion, joint defornlity and rheumatoid nodules, lower anti-CCP, AKA and APF antibodies positivity （P < 0.05）. There were no significant differences in the incidence of hand arthritis, polyarthritis, symmetrical arthritis and RF positivity （P > 0.05）. As compared with SLE patients, Rhupus patients had less malar erythema while no differences were observed in serositis, kidney, hematological involvement and ANA, anti-dsDNA antibody positivity （P > 0.05）. Conclusions Most of the Rhupus patients are firstly presented with RA and with severe arthritis. The positivity of ANA, anti-CCP and RF arehigh, are helpful to the diagnosis.
- Rhupus syndrome,
- Systemic lupus erythematosus,
- Rheumatoid arthritis,
- Overlap syndrome

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