Clinical Features of Rhupus Syndrome

Jin-yun CAI; Juan WANG; Rui-xi SUN; Ping FU

doi:10.12259/j.issn.2095-610X.S20210201

Volume 42 Issue 2

Mar. 2021

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Jin-yun CAI, Juan WANG, Rui-xi SUN, Ping FU. Clinical Features of Rhupus Syndrome[J]. Journal of Kunming Medical University, 2021, 42(2): 64-69. doi: 10.12259/j.issn.2095-610X.S20210201

Citation:

Jin-yun CAI, Juan WANG, Rui-xi SUN, Ping FU. Clinical Features of Rhupus Syndrome[J]. Journal of Kunming Medical University, 2021, 42(2): 64-69. doi: 10.12259/j.issn.2095-610X.S20210201

Jin-yun CAI, Juan WANG, Rui-xi SUN, Ping FU. Clinical Features of Rhupus Syndrome[J]. Journal of Kunming Medical University, 2021, 42(2): 64-69. doi: 10.12259/j.issn.2095-610X.S20210201

Citation:

Jin-yun CAI, Juan WANG, Rui-xi SUN, Ping FU. Clinical Features of Rhupus Syndrome[J]. Journal of Kunming Medical University, 2021, 42(2): 64-69. doi: 10.12259/j.issn.2095-610X.S20210201

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Clinical Features of Rhupus Syndrome

doi: 10.12259/j.issn.2095-610X.S20210201

Dept. of Rheumatology，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2020-11-26
Publish Date: 2021-03-05

Abstract

Abstract

Objective To analyse the clinical features of Rhupus syndrome. Methods The medical records of 21 Rhupus syndrome patients who were admitted to the Second Affiliated Hospital of Kunming Medical University from 2015 to 2019 were analysed retrospectively. One hundred and twenty RA patients and 45 SLE patients from our Unit were randomly selected as the controls. The data of patients in the three groups were compared. Results Twenty-one patients with Rhupus syndrome were female, 61.9% patients were initiallypresented with RA. The age of onset was significantly younger than that of RA （P < 0.05）, but similar to that of SLE. Rhupus patients had longer diseaseduration than control groups.As compared with RA patients, Rhupus patients had higher incidence of bone erosion, joint defornlity and rheumatoid nodules, lower anti-CCP, AKA and APF antibodies positivity （P < 0.05）. There were no significant differences in the incidence of hand arthritis, polyarthritis, symmetrical arthritis and RF positivity （P > 0.05）. As compared with SLE patients, Rhupus patients had less malar erythema while no differences were observed in serositis, kidney, hematological involvement and ANA, anti-dsDNA antibody positivity （P > 0.05）. Conclusions Most of the Rhupus patients are firstly presented with RA and with severe arthritis. The positivity of ANA, anti-CCP and RF arehigh, are helpful to the diagnosis.
- Rhupus syndrome,
- Systemic lupus erythematosus,
- Rheumatoid arthritis,
- Overlap syndrome

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References(19)

References

[1]	As J,Lupus H S J. The definition for coexistent rheumatoid arthritis and systemic lupus erythematosus[J]. Lupus,1995,4(2):166-168.
[2]	Iaccarino L,Gatto M,Bettio S,et al. Overlap connective tissue disease syndromes[J]. Autoimmunity Reviews,2013,12(3):363-373. doi: 10.1016/j.autrev.2012.06.004
[3]	Petri M,Orbai A M,Alarc¨®N G S,et al. Derivation and validation of the systemic lupus international collaborating Clinics classification criteria for systemic lupus erythematosus[J]. Arthritis Rheum,2012,64(8):2677-2686. doi: 10.1002/art.34473
[4]	Aletaha D,Neogi T,Silman A J,et al. 2010 Rheumatoid arthritis classification criteria:an american college of rheumatology/european league against rheumatism collaborative initiative[J]. Arthritis Rheum,2010,62(9):2569-2581. doi: 10.1002/art.27584
[5]	Aletaha D,Wang X,Zhong S,et al. Differences in disease activity measures in patients with rheumatoid arthritis who achieved DAS,SDAI,or CDAI remission but not boolean remission[J]. Seminars in Arthritis and Rheumatism,2020,50(2):276-284. doi: 10.1016/j.semarthrit.2019.09.005
[6]	Bajema I M,Wilhelmus S,Alpers C E,et al. Revision of the International society of nephrology/renal pathology society classification for lupus nephritis:clarification of definitions,and modified national institutes of health activity and chronicity indices[J]. Kidney International,2018,93(4):789-796. doi: 10.1016/j.kint.2017.11.023
[7]	Shovman O,Langevitz P,SHOENFELD Y. Rhupus;unusual presentations[J]. Clin Rheumatol,2015,34(12):2041-2046. doi: 10.1007/s10067-015-2978-y
[8]	J L,H W,X H,et al. Clinical analysis of 56 patients with rhupus syndrome:manifestations and comparisons with systemic lupus erythematosus:a retrospective case-control study[J]. Medicine(Baltimore),2014,93(10):e49.
[9]	Liu T,Li G,MU R,et al. Clinical and laboratory profiles of rhupus syndrome in a Chinese population:a single-centre study of 51 patients[J]. Lupus,2014,23(9):958-963. doi: 10.1177/0961203314526439
[10]	Tani C,D'aniello D,Dellesedie A,et al. Rhupus syndrome:assessment of its prevalence and its clinical and instrumental characteristics in a prospective cohort of 103 SLE patients[J]. Autoimmunity Teviews,2013,12(4):537-541. doi: 10.1016/j.autrev.2012.09.004
[11]	S G,S D,TA K,et al. Organising pneumonia in rhupus syndrome[J]. BMJ Case Rep,2019,12(12):e232326. doi: 10.1136/bcr-2019-232326
[12]	Panagopoulos P K,Lambrou G I. Bone erosions in rheumatoid arthritis:recent developments in pathogenesis and therapeutic implicatio ns[J]. J Musculoskelet Neuronal Interact,2018,18(3):304-319.
[13]	Aurell Y,Andersson M,Forslind K. Cone-beam computed tomography,a new low-dose three-dimensional imaging technique for assessment of bone erosions in rheumatoid arthritis:reliability assessment and comparison with conventional radiography - a BARFOT study[J]. Scand J Rheumatol,2018,47(3):173-177. doi: 10.1080/03009742.2017.1381988
[14]	Hallert E,Björk M,Dahlström O,et al. Disease activity and disability in women and men with early rheumatoid arthritis(RA):an 8-year foll owup of a Swedish early RA project[J]. Arthritis Care Res(Hoboken),2012,64(8):1101-1107.
[15]	Tian M,Song X,Dong L,et al. Systematic evaluation of different doses of cyclophosphamide induction therapy for lupus nephritis[J]. Medicine(Baltimore),2017,96(51):e9408.
[16]	张桌莉. 吗替麦考酚酯在自身免疫病治疗中应用的风湿病专家共识[J]. 中华风湿病学杂志,2019,23(7):436-440. doi: 10.3760/cma.j.issn.1007-7480.2019.07.002
[17]	Zengin O,Onder M E,Sarica M A,et al. Systemic vasculitis in a patient with rhupus syndrome[J]. Reumatismo,2015,67(4):161-164.
[18]	Zaman S,Rahim M A,Sayami L A,et al. Libman-sacks endocarditis in a Bangladeshi patient suffering from rhupus[J]. Trop Doct,2019,49(4):309-311. doi: 10.1177/0049475519854623
[19]	Nizami M F,Sharma C B,Guria R T,et al. A rare case of rhupus syndrome with hashimoto's thyroiditis,associated adverse effect of drugs and i ncidental findings[J]. J Family Med Prim Care,2019,8(9):3048-3050. doi: 10.4103/jfmpc.jfmpc_568_19

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