Distribution Characteristics of <i>MTHFR 677C &gt; T</i> Gene Polymorphism in Pregnant Women and Its Correlation with Hypertension during Pregnancy

Ting PI; Yue-qin LIANG; Li DING; Ling YANG; Ying-ying XIANG

doi:10.12259/j.issn.2095-610X.S20210215

Volume 42 Issue 2

Mar. 2021

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Ting PI, Yue-qin LIANG, Li DING, Ling YANG, Ying-ying XIANG. Distribution Characteristics of MTHFR 677C > T Gene Polymorphism in Pregnant Women and Its Correlation with Hypertension during Pregnancy[J]. Journal of Kunming Medical University, 2021, 42(2): 86-90. doi: 10.12259/j.issn.2095-610X.S20210215

Citation:

Ting PI, Yue-qin LIANG, Li DING, Ling YANG, Ying-ying XIANG. Distribution Characteristics of MTHFR 677C > T Gene Polymorphism in Pregnant Women and Its Correlation with Hypertension during Pregnancy[J]. Journal of Kunming Medical University, 2021, 42(2): 86-90. doi: 10.12259/j.issn.2095-610X.S20210215

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Distribution Characteristics of MTHFR 677C > T Gene Polymorphism in Pregnant Women and Its Correlation with Hypertension during Pregnancy

doi: 10.12259/j.issn.2095-610X.S20210215

1.
Dept. of Pharmacy
2.
Dept. of Obstetrics
3.
Dept. of Stomatology Yan’an Hospital of Kunming City，Kunming Yunnan 650051，China

Received Date: 2020-11-06
Publish Date: 2021-03-05

Abstract

Abstract

Objective To inverstigate the association between methylenetetrahydrofolate reductase （MTHFR）677C > T gene polymorphism and pregnancy induced hypertension in pregnant women. Methods Ninety HDCP patients who underwent prenatal examination in Yan'an Hospital of Kunming City from October 2016 to September 2017 were selected as the experimental group, and 2386 pregnant women without HDCP were selected as the control group. The correlation between the polymorphism of MTHFR 677C > T gene and the experimental group and the control group was analyzed by digital fluorescence molecular hybridization（DFMH）. Results The genotype frequencies of MTHFR 677C > T CT were 52.22% in the experimental group and 44.38% in the control group. There was no significant difference between the two groups（P > 0.05）. The frequency of mutant T allele was 37.22% in the experimental group and 37.07% in the control group. There was no significant difference between the two groups（P > 0.0）. Conclusion The 677C > T polymorphism of MTHFR gene may not be a risk factor for HDCP, and may not be associated with the occurrence of HDCP, but it may also result from the limitation of retrospective study
- Methylenetetrahydrofolate reductase（MTHFR）,
- Hypertensive disorder complication pregnancy,
- Folic acid,
- Polymorphism,
- Individualization

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References(19)

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