Efficacy and Prognosis of Levetiracetam Injection in the Treatment of Convulsive Status Epilepsy

Hao-hao WU; Jun-su YANG; Bao-gang HUANG; Shao-yong GUAN; Yan ZHENG; Hui-juan FAN

doi:10.12259/j.issn.2095-610X.S20211031

Volume 42 Issue 10

Oct. 2021

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Hao-hao WU, Jun-su YANG, Bao-gang HUANG, Shao-yong GUAN, Yan ZHENG, Hui-juan FAN. Efficacy and Prognosis of Levetiracetam Injection in the Treatment of Convulsive Status Epilepsy[J]. Journal of Kunming Medical University, 2021, 42(10): 151-156. doi: 10.12259/j.issn.2095-610X.S20211031

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Efficacy and Prognosis of Levetiracetam Injection in the Treatment of Convulsive Status Epilepsy

doi: 10.12259/j.issn.2095-610X.S20211031

Dept. of Neurology，Qujing No.1 Hospital，Yunnan Qujing 655000，China

Received Date: 2021-08-24
Available Online: 2021-10-29
Publish Date: 2021-10-30

Abstract

Abstract

Objective To analyze the control effect and prognosis of Levetiracetam injection on convulsive epileptic status （CSE）, in order to promote its clinical application. Methods A total of 80 CSE patients were enrolled in the Department of Neurology intensive Care Unit （NICU） of Qujing No.1 Hospital from September 2018 to April 2021. 40 patients in the Levetiracetam group （experimental group） and 40 patients in the Valproate group （control group） were randomly assigned to compare the efficacy, adverse reactions, EEG changes, Synek grading and prognosis. Results The effective control rate was 77.5% in the Levetiracetam group and 67.5% in the Valproate group, with no statistical difference between the two groups （P = 0.317）. The onset time of Levetiracetam group was shorter than that of Valproate group, and the difference between the two groups was statistically significant （P < 0.05）. Prognostic analysis: Univariate analysis showed that symptoms were not effectively controlled, successful control time ≥60 min, abnormal discharge in EEG, Synek grading and poor prognosis were significantly correlated （P < 0.05）. Multivariate Logitstic regression analysis showed that, Synek grade was negatively correlated with prognosis （β= -3.867, OR < 1）, and higher Synek grade was an independent risk factor and predictor of poor prognosis （P < 0.05）. Conclusion Levetiracetam injection can control CSE more quickly and effectively, which can be used in clinic. EEG analysis （EEG abnormal discharge and Synek grading） can provide a reliable basis for judging the prognosis of CSE.
- Levetiracetam injection,
- Convulsive status epilepticus,
- Brain function,
- Prognosis

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