Clinical Features and Related Prognostic Factors of 88 Cases of Duodenal Adenocarcinoma

Zhengqin GENG; Lin XIE; Hongli SONG; Rong LI; Yedan LIAO; Xueqi ZhANG; Jiadai TANG

doi:10.12259/j.issn.2095-610X.S20220109

Volume 43 Issue 1

Jan. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(1): 53-58

Zhengqin GENG, Lin XIE, Hongli SONG, Rong LI, Yedan LIAO, Xueqi ZhANG, Jiadai TANG. Clinical Features and Related Prognostic Factors of 88 Cases of Duodenal Adenocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(1): 53-58. doi: 10.12259/j.issn.2095-610X.S20220109

Citation:

Zhengqin GENG, Lin XIE, Hongli SONG, Rong LI, Yedan LIAO, Xueqi ZhANG, Jiadai TANG. Clinical Features and Related Prognostic Factors of 88 Cases of Duodenal Adenocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(1): 53-58. doi: 10.12259/j.issn.2095-610X.S20220109

Citation:

Zhengqin GENG, Lin XIE, Hongli SONG, Rong LI, Yedan LIAO, Xueqi ZhANG, Jiadai TANG. Clinical Features and Related Prognostic Factors of 88 Cases of Duodenal Adenocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(1): 53-58. doi: 10.12259/j.issn.2095-610X.S20220109

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Clinical Features and Related Prognostic Factors of 88 Cases of Duodenal Adenocarcinoma

doi: 10.12259/j.issn.2095-610X.S20220109

1.
Dept.of Gastrointestinal Oncology，Yunnan Cancer Hospital/The Third Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118
2.
Dept. of Gynecology，Qujing Maternal and Child Health Hospital，Qujing Yunnan 655000，China

Received Date: 2021-12-08
Available Online: 2021-12-20
Publish Date: 2022-01-15

Abstract

Abstract

Objective To analyze the clinical characteristics and related prognostic factors of patients with duodenal adenocarcinoma. Methods 88 patients with duodenal adenocarcinoma who were pathologically diagnosed and admitted to Yunnan Cancer Hospital from January 2010 to December 2019 were studied retrospectively. The Kaplan-Meier method was used to evaluate the survival status of patients, the Log-rank test was used for univariate analysis, and the Cox proportional hazard regression model was used for multivariate analysis to screen out the relevant risk factors affecting the prognosis of patients with duodenal adenocarcinoma. Results The age range of 88 patients with duodenal adenocarcinoma: 23-79 years old, with an average age of 54.83 years old, male to female ratio: 1.44∶1. Survival analysis showed that the median survival time of patients with and without metastasis of duodenal adenocarcinoma was 14 months and 19 months respectively, the prognosis of patients with metastasis was worse than those without metastasis （P < 0.05）. Univariate analysis showed that the presence or absence of metastasis, primary tumor diameter, clinical stage, chemotherapy regimens, types of chemotherapy drugs, surgical methods, Hp infection, CEA, CA199, AST/ALT, NKC, PLT, LMR were related to the prognosis of duodenal adenocarcinoma patients （P < 0.05）. Cox multivariate analysis suggested that metastasis, Hp （+）, CA199 > 27 U/mL were the independent risk factors affecting the prognosis of patients with duodenal adenocarcinoma （P < 0.05）, and radical surgery was the duodenal Beneficial factors for the prognosis of patients with adenocarcinoma （P < 0.05）. Conclusion The prognosis of duodenal adenocarcinoma with metastasis is extremely poor, and early close monitoring is needed. Clinically, the prognosis of patients can be predicted by four indicators of metastasis, surgical method, Hp infection, and CA199.
- Duodenal adenocarcinoma,
- Clinical features,
- Prognosis

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