Volume 43 Issue 1
Jan.  2022
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Tingting YU, Dongling LI, Hongying WANG, Lihua LI, Dong PU, Kunli WU. Investigations on the Infection, Immunity and Drug Resistance of Newly-treated Cases of HIV in Kunming[J]. Journal of Kunming Medical University, 2022, 43(1): 138-143. doi: 10.12259/j.issn.2095-610X.S20220133
Citation: Tingting YU, Dongling LI, Hongying WANG, Lihua LI, Dong PU, Kunli WU. Investigations on the Infection, Immunity and Drug Resistance of Newly-treated Cases of HIV in Kunming[J]. Journal of Kunming Medical University, 2022, 43(1): 138-143. doi: 10.12259/j.issn.2095-610X.S20220133

Investigations on the Infection, Immunity and Drug Resistance of Newly-treated Cases of HIV in Kunming

doi: 10.12259/j.issn.2095-610X.S20220133
  • Received Date: 2021-12-10
    Available Online: 2021-12-20
  • Publish Date: 2022-01-15
  •   Objective  To investigate the infection, immunity, and drug resistance of newly-treated HIV cases in Kunming. The clinical characteristics and virological characteristics were jointly analyzed, so as to provide a basis to determine the ease of treatment and individualized solutions for antiviral precision treatment.   Method  The HIV-RNA , HCV-RNA, HBV-DNA, CD4 cell count, ALT, AST, Hb, PLT, ALB, HIV typing and resistance testing in 200 cases of newly-treated cases of HIV were detected before the therapy.  Result  The mainly infection route of newly-treated cases of HIV in Kunming was the heterosexual transmission, accounting for 80.5%, and MSM people also occupied a certain proportion (6.5%). Youth and seniors accounted for 25%. CD4 level was negatively correlated with viral load in newly-treated cases of HIV in Kunming (r = -0.58, P < 0.05), and 83 cases of them suffered from the opportunistic concurrent infection. HIV subtype had the highest proportion with CRF08_BC subtype in newly-treated cases of HIV in Kunming (27.5%). A total of 7 infected persons were detected resistance mutation sites in 200 newly-treated cases of HIV in Kunming. Primary resistance rate was 3.5%.   Conclusion  New features of HIV spreading in Kunming have emerged. The route of transmission has changed from intravenous drug use to heterosexual transmission. Increasing proportion of MSM population, adolescents and the Elderly. HIV subtypes have unique distribution characteristics in Kunming. The overall immune status is low. Primary resistance rate is 3.5%.
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  • [1]
    中国共产党中央委员会,中华人民共和国国务院. "健康中国2030"规划纲要[J]. 中国实用乡村医生杂志,2017,24(7):1-12. doi: 10.3969/j.issn.1672-7185.2017.07.002
    [2]
    国务院办公厅. 国务院办公厅关于印发中国遏制与防治艾滋病“十三五”行动计划的通知[EB/OL]. (2017-01-19) [2017-02-05]. http://www.gov.cn/zhengce/content/2017-02/05/content_5165514.htm
    [3]
    孟莛,李文. 人才织就中国防艾网[J]. 中国卫生人才,2019,251(3):15.
    [4]
    范雄智,刘仲琦,程伟彬,等. 男男性行为人群同伴社会网络规范对其HIV检测行为的影响[J]. 中华疾病控制杂志,2018,22(1):38-41.
    [5]
    江河,朱秋映,蓝光华,等. 广西壮族自治区艾滋病抗病毒治疗患者CD4+T淋巴细胞动态趋势及影响因素分析[J]. 中华流行病学杂志,2015,36(10):1125-1128. doi: 10.3760/cma.j.issn.0254-6450.2015.10.019
    [6]
    World Health Organization. . HIV drug resistance report 2017 [EB/OL]. (2017). https://apps.who.int/iris/handle/10665/255896.
    [7]
    Wittkop L,G ü nthard H F,De W F,et al. Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project):A European multicohort study[J]. Lancet Infect Dis,2011,11(5):363-371. doi: 10.1016/S1473-3099(11)70032-9
    [8]
    UNAIDS. End inequalities. End AIDS. Global AIDS strategy 2021-2026[EB/OL]. (2021). https://www.unaids.org/en/Global-AIDS-Strategy-2021-2026.
    [9]
    钟敏,李韩平,李惠琴,等. 云南省2012年人类免疫缺陷病毒感染者和艾滋病患者抗病毒治疗失败基因型耐药情况分析[J]. 中华传染病杂志,2015,33(1):30-33.
    [10]
    陈鹏,李丰,朱三梅,等. 湖南省株洲市 2008-2018年报告的老年HIV/AIDS病例流行特征[J]. 中国热带医学,2019,19(9):868-871,880.
    [11]
    吕松琴,黄山,李晓非,等. 昆明地区健康成年人外周血T淋巴细胞亚群参考区间调查[J]. 临床检验杂志,2017,35(4):310-313.
    [12]
    胡永芳,王鹏森,刘家秀,等. 重庆市HIV/AIDS病人首次病毒载量和CD4+T淋巴细胞检测结果及相关性[J]. 中国艾滋病性病,2014,20(11):812-814.
    [13]
    He Xiang,Xing Hui,Ruan Yuhua,et al. A comprehensive mapping of HIV-1 genotypes in various risk groups and regions across china based on a nationwide molecular epidemiologic survey[J]. PLoS One,2012,7(10):e47289. doi: 10.1371/journal.pone.0047289
    [14]
    李健健,李惠琴,李敬云等. 云南省2012-2014年HIV-1流行毒株亚型分布特征[J]. 中国艾滋病性病,2016,22(3):145-149.
    [15]
    Lataillade M,Chiarella J,Yang R,et al. Prevalence and clinical significance of HIV drug resistance mutations by ultradeep sequencing in antiretroviral-naive subjects in the CASTLE study[J]. PLoS One,2010,5(6):e10952. doi: 10.1371/journal.pone.0010952
    [16]
    Jordan M R,Bennett D E,Bertagnolio S,et al. World Health Organization surveys to monitor HIV drug resistance prevention and associated factors in sentinel antiretroviral treatment sites[J]. Antivir Ther,2008,13(2):15-23.
    [17]
    Diane E Bennett, Mark Myatt, Silvia Bertagnolio, et al. Recommendations for surveillance of transmitted HIV drug resistance in countries scaling up antiretroviral treatment[J]. Antivir Ther, 2008, 13 (Suppl 2): 25-36.
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