Research Progress of Akkermansia Muciniphila and Obesity-related Metabolic Diseases

Hongjiang ZHOU; Juan TANG; Lei LIANG; Xin NIAN

doi:10.12259/j.issn.2095-610X.S20220143

Volume 43 Issue 1

Jan. 2022

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Hongjiang ZHOU, Juan TANG, Lei LIANG, Xin NIAN. Research Progress of Akkermansia Muciniphila and Obesity-related Metabolic Diseases[J]. Journal of Kunming Medical University, 2022, 43(1): 157-162. doi: 10.12259/j.issn.2095-610X.S20220143

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Hongjiang ZHOU, Juan TANG, Lei LIANG, Xin NIAN. Research Progress of Akkermansia Muciniphila and Obesity-related Metabolic Diseases[J]. Journal of Kunming Medical University, 2022, 43(1): 157-162. doi: 10.12259/j.issn.2095-610X.S20220143

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Research Progress of Akkermansia Muciniphila and Obesity-related Metabolic Diseases

doi: 10.12259/j.issn.2095-610X.S20220143

Dept. of Endocrinology，The 1st Affiliated Hospital of Kunming Medical University， Kunming Yunnan 650032，China

Received Date: 2021-12-24
Available Online: 2022-01-15
Publish Date: 2022-01-15

Abstract

Abstract

The intestinal microbiota plays a vital role in regulating host immunity and energy metabolism, and is related to the occurrence of obesity, diabetes, and cardiovascular diseases. At present, various animal models and human studies have proved that Akkermansia muciniphila （Akkermansia muciniphila/A. muciniphila） levels are negatively correlated with the occurrence of metabolic diseases such as obesity, diabetes, obese liver disease, and atherosclerosis. A. muciniphila has broad prospects in the treatment of metabolic disorders by increasing the thickness of the intestinal mucus layer, reducing systemic inflammation, improving glucose tolerance and insulin resistance, and is considered to be a new generation of therapeutic drugs. This article systematically reviews the basic mechanism of the interaction between A. muciniphila and metabolic diseases and hosts.
- Akkermansia muciniphila,
- Intestinal barrier,
- Systemic inflammation,
- Insulin resistance

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References(45)

References

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