Comparative Analysis of the Effects of Hydromorphone and Sufentanil on Early Postoperative Cognitive Function in Patients with Intravenous Controlled Analgesia after Radical Resection of Colorectal Cancer

Shiguo LI; Shulan JIAO

doi:10.12259/j.issn.2095-610X.S20220308

Volume 43 Issue 3

Mar. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > 43(3): 98-102

Shiguo LI, Shulan JIAO. Comparative Analysis of the Effects of Hydromorphone and Sufentanil on Early Postoperative Cognitive Function in Patients with Intravenous Controlled Analgesia after Radical Resection of Colorectal Cancer[J]. Journal of Kunming Medical University, 2022, 43(3): 98-102. doi: 10.12259/j.issn.2095-610X.S20220308

Citation:

Shiguo LI, Shulan JIAO. Comparative Analysis of the Effects of Hydromorphone and Sufentanil on Early Postoperative Cognitive Function in Patients with Intravenous Controlled Analgesia after Radical Resection of Colorectal Cancer[J]. Journal of Kunming Medical University, 2022, 43(3): 98-102. doi: 10.12259/j.issn.2095-610X.S20220308

Citation:

Shiguo LI, Shulan JIAO. Comparative Analysis of the Effects of Hydromorphone and Sufentanil on Early Postoperative Cognitive Function in Patients with Intravenous Controlled Analgesia after Radical Resection of Colorectal Cancer[J]. Journal of Kunming Medical University, 2022, 43(3): 98-102. doi: 10.12259/j.issn.2095-610X.S20220308

PDF( 662 KB)

Comparative Analysis of the Effects of Hydromorphone and Sufentanil on Early Postoperative Cognitive Function in Patients with Intravenous Controlled Analgesia after Radical Resection of Colorectal Cancer

doi: 10.12259/j.issn.2095-610X.S20220308

Shiguo LI^1
,,
Shulan JIAO²

1.
Dept. of Anesthesiology，Medical Center Hospital Of Qionglai City，Chengdu Sichuan 611500
2.
Dept. of Anesthesiology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2022-01-18
Available Online: 2022-02-18
Publish Date: 2022-03-22

Abstract

Abstract

Objective To compare the effects of hydromorphone and sufentanil on early postoperative cognitive function in patients with colorectal cancer. Methods Eighty-five patients with selective radical resection of colorectal cancerr （including laparoscopic surgery or open surgery） were randomly divided into hydromorphone group of 44 （H group） and sufentanil group of 41 （S group） by random number table method. Postoperative H group was treated with hydromorphone for intravenous analgesia. Group S was treated with sufentanil for intravenous analgesia. Visual analogue score （VAS） was recorded at 6, 12, 24, 48 h after surgery. The adverse reactions such as nausea, vomiting, skin itching, respiratory inhibition, hypotension and dizziness occurred within 48 hours after the operation were observed. Ramsay sedation score was recorded 24 hours after surgery. Mini-Mental State Examination （MMSE） scores were recorded at 1, 2, 3 d after the operation were recorded. Results There was no significant difference in postoperative VAS scores between the two groups （P > 0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups within 48 hours after surgery （P > 0.05）. There was no statistically significant difference in Ramsay sedation score at 24h after surgery between the two groups （P > 0.05）. There was a statistical difference in the postoperative MMSE score between the two groups （P < 0.05）. The incidence of postoperative cognitive dysfunction （POCD） in group H was 15.9% （7/44）, and group S 39% （16/41）. There was a statistical difference in the incidence of POCD between the two groups （P < 0.05）. The grouping factor was an independent one affecting the occurrence of POCD （OR = 3.307, P < 0.05）. Conclusions Hydromorphone and sufentanil are both safe and effective for intravenous controlled analgesia in patients after radical resection of colorectal cancer with no difference in analgesia. Compared with sufentanil, hydromorphone can significantly improve the cognitive impairment of patients after radical colon cancer.
- Hydromorphone,
- Sufentanil,
- Postoperative cognitive dysfunction,
- Patient-controlled intravenous analgesia

FullText(HTML)

References(17)

References

[1]	Schenning K J,Murchison C F,Mattek N C,et al. Sex and genetic differences in postoperative cognitive dysfunction:a longitudinal cohort analysis[J]. Biol Sex Differ,2019,10(1):14. doi: 10.1186/s13293-019-0228-8
[2]	王建生,李仕国,牟宏宇. 不同麻醉、镇痛方法对行全关节成形术老年患者术后早期认知功能的影响[J]. 山东医药,2014,54(21):79-81.
[3]	Kristek G,Radoš I,Kristek D,et al. Influence of postoperative analgesia on systemic inflammatory response and postoperative cognitive dysfunction after femoral fractures surgery:a randomized controlled trial[J]. Reg Anesth Pain Med,2019,44(1):59-68. doi: 10.1136/rapm-2018-000023
[4]	Kurita G P,Sjøgren P,Ekholm O,et al. Prevalence and predictors of cognitive dysfunction in opioid-treated patients with cancer:a multinational study[J]. J Clin Oncol,2011,29(10):1297-303. doi: 10.1200/JCO.2010.32.6884
[5]	Yang Y,Wu J,Li H,et al. Prospective investigation of intravenous patient-controlled analgesia with hydromorphone or sufentanil:impact on mood,opioid adverse effects,and recovery[J]. BMC Anesthesiol,2018,18(1):37. doi: 10.1186/s12871-018-0500-1
[6]	王晓伟,孙天胜,张建政,等. 美国麻醉医师协会分级对老年髋部骨折患者预后的预测作用[J]. 中华创伤杂志,2020,12(1):31-33. doi: 10.3760/cma.j.issn.1001-8050.2020.01.008
[7]	金平,陆凤娇,杨园园,等. 氢吗啡酮用于患儿术后父母控制静脉镇痛的效果[J]. 中华麻醉学杂志,2017,37(8):947-950. doi: 10.3760/cma.j.issn.0254-1416.2017.08.013
[8]	杨琳,魏冬霞,杨璞静. PVP和PKP治疗老年性骨质疏松性椎体压缩性骨折的疗效观察与护理[J]. 护理实践与研究,2019,16(2):108-110. doi: 10.3969/j.issn.1672-9676.2019.02.043
[9]	冯晓潞,蔡越,赵丽,等. 右美托咪定不同给药方式对胃癌根治术老年患者认知功能及Ramsay镇静评分的影响[J]. 肿瘤研究与临床,2021,22(5):102-106.
[10]	姚素红,潘雪红,蔡敏慧. 叙事护理联合整体护理对老年痴呆患者MMSE评分、精神状态及日常生活能力的影响[J]. 国际护理学杂志,2021,42(19):76-79.
[11]	Kang B M,Kim H J,Kye B H,et al. Multicenter,randomized single-port versus multiport laparoscopic surgery (SIMPLE) trial in colon cancer:an interim analysis[J]. Surg Endosc,2018,32(3):1540-1549. doi: 10.1007/s00464-017-5842-0
[12]	Oviedo-Joekes E,Guh D,Brissette S,et al. Hydromorphone compared with diacetylmorphine for long-term opioid dependence:A randomized clinical trial[J]. JAMA Psychiatry,2016,73(5):447-455. doi: 10.1001/jamapsychiatry.2016.0109
[13]	Mazer-Amirshahi M,Motov S,Nelson L S. Hydromorphone use for acute pain:Misconceptions,controversies,and risks[J]. J Opioid Manag,2018,14(1):61-71. doi: 10.5055/jom.2018.0430
[14]	M ü ller J,Nowak S,Vogelgesang A,et al. Evaluating mechanisms of postoperative delirium and cognitive dysfunction following elective spine surgery in elderly patients (CONFESS):Protocol for a prospective observational trial[J]. JMIR Res Protoc,2020,9(2):e15488. doi: 10.2196/15488
[15]	Wang L,Johnston B,Kaushal A,et al. Ketamine added to morphine or hydromorphone patient-controlled analgesia for acute postoperative pain in adults:A systematic review and meta-analysis of randomized trials[J]. Can J Anaesth,2016,63(3):311-325. doi: 10.1007/s12630-015-0551-4
[16]	刘冬. κ阿片受体激动剂通过PKA-CREB信号通路对大鼠体外循环术后认知功能的保护作用[D]. 锦州: 锦州医科大学硕士学位论文, 2018.
[17]	郑翔. κ阿片受体激动剂通过CAP信号通路对体外循环大鼠术后认知功能的保护作用[D]. 大连: 大连医科大学硕士学位论文, 2017.

Relative Articles(20)

Relative Articles

[1]	Li-yuan AN, Bing LI, Gang SU. Effects of Different Doses of Ulinastatinon Postoperative Cognitive Function and HMGB1 in Elderly Patients. Journal of Kunming Medical University, 2021, 42(7): 121-125. doi: 10.12259/j.issn.2095-610X.S20210720
[2]	Dan-ni ZHANG, Xia-guang DUAN, Chun-guang HAO, Xiao-jun ZHI, Hai-feng ZHU, Zai-qing HUANG. Anesthetic Effects and Mechanism of Hydromorphone Combined with Propofol on Colorectal Dilatation Model. Journal of Kunming Medical University, 2021, 42(7): 25-30. doi: 10.12259/j.issn.2095-610X.S20210705
[3]	Li Rui , Si Yong Yu , Lu Ming Liang , Cai Ying . . Journal of Kunming Medical University, 2020, 41(07): 116-120.
[4]	Dinesh Kumar Shrestha, Liu Ping , Zhang Fu Rong . . Journal of Kunming Medical University, 2019, 40(10): 109-112.
[5]	Han Juan , Xu Hong . . Journal of Kunming Medical University, 2018, 39(10): 68-71.
[6]	Chen Xue Qiang , Huang Chun Gui , Yu Li Xian , Yang Yun Li . The Effect of PCSA with Parecoxib Sodium and Sufentanil on the Postoperative Delirium in Patients after the Spinal Surgery. Journal of Kunming Medical University, 2018, 39(01): 92-95.
[7]	Duan Er Yun , Jiao Shu Lan , Yang Jian . . Journal of Kunming Medical University, 2018, 39(10): 79-83.
[8]	Zhang Min Li , Shen Zhong Ming , Zhu Sha , Zhang Juan Juan . The Effect of Dezocine Analgesia on Cognitive Function of Patients after Gynecological Laparoscopic Surgery. Journal of Kunming Medical University, 2016, 37(12): 107-110.
[9]	Pang Jia Ning , Liu Jing Song , Li Xi , Wang Li Zhu , Zhang Xi Hua . Early Analgesic Effect of Continuous Femoral Nerve Block for Total Knee Arthroplasty. Journal of Kunming Medical University, 2016, 37(11): 64-69.
[10]	Liu Qing Hua . The Effect of Propofor Combined with Shufen on Analgesia，Analepsia and Adverse Reactions of Laparoscopic Myomectomy. Journal of Kunming Medical University,
[11]	Wen Kai Lan . . Journal of Kunming Medical University,
[12]	Tang Ling Ling . . Journal of Kunming Medical University,
[13]	Tang Ling Ling . . Journal of Kunming Medical University,
[14]	Qu Qi Cai . . Journal of Kunming Medical University,
[15]	Li Cui Lin . . Journal of Kunming Medical University,
[16]	Zhao Min . . Journal of Kunming Medical University,
[17]	Zhao Xiao Hong . . Journal of Kunming Medical University,
[18]	Liu Shu Qing . . Journal of Kunming Medical University,
[19]	Jiang Hai Xia . . Journal of Kunming Medical University,
[20]	. Clinical Observation of Remifentanil for Postoperative Analgesia Safety and Efficacy in ICU Patients after Operation. Journal of Kunming Medical University,