Volume 43 Issue 6
Jun.  2022
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Article Navigation >  Journal of Kunming Medical University  > 2022  >  43(6): 13-18
Rui CUN, Meiling CHEN. Efficacy and Clinical Application of Flunarizine Combined with Ginkgo damo in Treatment of Senile Vertigo[J]. Journal of Kunming Medical University, 2022, 43(7): 116-120. doi: 10.12259/j.issn.2095-610X.S20220703
Citation: Jingling LI, Kunbin KE, Zhencheng WANG, Deqiang QIN, Hao LI. A Preliminary Study of CASR/VDR/PTH1R Signaling Pathway in the Pathogenesis of Calcium-containing Kidney Stones[J]. Journal of Kunming Medical University, 2022, 43(6): 13-18. doi: 10.12259/j.issn.2095-610X.S20220609
shu

A Preliminary Study of CASR/VDR/PTH1R Signaling Pathway in the Pathogenesis of Calcium-containing Kidney Stones

doi: 10.12259/j.issn.2095-610X.S20220609

  • Dept. of Urinary Surgery，The First Affiliated Hospital of Kunming Medical University， Kunming Yunnan 650032，China

  • Received Date: 2022-03-08
    Available Online: 2022-06-07
  • Publish Date: 2022-06-30
    Abstract
  •   Objective  To study the role and mechanism of CASR, VDR, PTH1R and other genes in the occurrence of calcium-containing kidney stones.   Methods  The renal medulla of patients with renal calculi was selected as the experimental group, and the normal renal medulla of patients with renal tumors was selected as the control group. The mRNA expression and protein level of CASR, VDR and PTH1R in renal solid tissue were detected by q-PCR, WB and immunofluorescence, respectively.   Results  There was no significant difference in the expression levels of CASR and PTH1R gene mRNA in the hydronephrotic medulla and the normal medulla of renal tumor （P > 0.05）. The difference of VDR gene mRNA expression in hydronephrotic medulla and normal medulla of renal tumor was statistically significant （P < 0.05）.  Conclusion  CASR, VDR, and PTH1R are involved in the occurrence of calcium-containing kidney stones, and may participate in the mechanism of calcium-containing kidney stones through the CASR/VDR/PTH1R signaling pathway.
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