Recombinant Human Epidermal Growth Factor on the Repairing Effect of Sensitive Skin in High Altitude Areas in Yunnan Province

Qingzhu ZHOU; Zhuo GONG; Xian ZHAO; Boyan LIU; Wenli HUANG; Jia HE; Liu LIU; Pufei PU

doi:10.12259/j.issn.2095-610X.S20220627

Volume 43 Issue 6

Jun. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(6): 41-45

Qingzhu ZHOU, Zhuo GONG, Xian ZHAO, Boyan LIU, Wenli HUANG, Jia HE, Liu LIU, Pufei PU. Recombinant Human Epidermal Growth Factor on the Repairing Effect of Sensitive Skin in High Altitude Areas in Yunnan Province[J]. Journal of Kunming Medical University, 2022, 43(6): 41-45. doi: 10.12259/j.issn.2095-610X.S20220627

Citation:

Qingzhu ZHOU, Zhuo GONG, Xian ZHAO, Boyan LIU, Wenli HUANG, Jia HE, Liu LIU, Pufei PU. Recombinant Human Epidermal Growth Factor on the Repairing Effect of Sensitive Skin in High Altitude Areas in Yunnan Province[J]. Journal of Kunming Medical University, 2022, 43(6): 41-45. doi: 10.12259/j.issn.2095-610X.S20220627

Citation:

Qingzhu ZHOU, Zhuo GONG, Xian ZHAO, Boyan LIU, Wenli HUANG, Jia HE, Liu LIU, Pufei PU. Recombinant Human Epidermal Growth Factor on the Repairing Effect of Sensitive Skin in High Altitude Areas in Yunnan Province[J]. Journal of Kunming Medical University, 2022, 43(6): 41-45. doi: 10.12259/j.issn.2095-610X.S20220627

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Recombinant Human Epidermal Growth Factor on the Repairing Effect of Sensitive Skin in High Altitude Areas in Yunnan Province

doi: 10.12259/j.issn.2095-610X.S20220627

Dept. of Plastic Surgery of Kunming First People’s Hospital，Kunming Yunnan 650000，China

Received Date: 2022-03-19
Available Online: 2022-06-08
Publish Date: 2022-06-30

Abstract

Abstract

Objective To observe the repairing effect of recombinant human epidermal growth factor （EGF） on sensitive skin in high altitude area of Yunnan province. Methods This study retrospectively analyzed 100 cases of sensitive skin female patients aged 20 to 60 years old from Yunnan in our institution from March 2021 to September 2021, accompanied by redness, itching, red blood streaks, stains, enlarged pores and other symptoms. The subjects were divided into control group （n = 25）, experiment group 1 （n = 25）, experiment group 2 （n = 25）, experiment group 3 （n = 25）. All the 4 groups were injected 14mg/ml non-crosslinked sodium hyaluronate 2ml into the dermis of the whole face with DermaShine model 1 generation electronic injection, once every 30 days for 5 consecutive times, experimental group 1 was injected with 10000 units of EGF solution each time, experimental group 2 was injected with 5000 units of EGF solution each time, experimental group 3 was injected with 2500 solution units of EGF each time. VISIA skin analysis apparatus was used for data analysis before and after injection, and patients' skin sensitivity self-assessment data, doctor's objective score data and VISIA red zone feature count data were recorded before injection, after 1 injection, 2 injections, 3 injections, 4 injections and 5 injections respectively. All data were collected for statistical analysis. The improvement of skin texture, color and pore was compared before and after injection . Results Data analysis results showed that, 1. The repairing effect of sensitive skin in the experimental group was significantly higher than that in the control group （P < 0.05）. 2. The self-assessment of skin sensitivity and the objective score of doctors in the experimental group was significantly higher than that in the control group （P < 0.05）. 3. The repair effect rate of experimental group 1 was significantly higher than that in experimental group 2 and experimental group 3 （P < 0.05）. 4. The experimental group improved the skin spots, wrinkles and pores. Conclusion EGF can effectively repair sensitive skin in high altitude area of Yunnan province, and provide a new clinical idea for skin treatment in Yunnan province.
- Recombinant human epidermal growth factor,
- Non-crosslinked sodium hyaluronate,
- High altitude area,
- Sensitive skin,
- Repair

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References(10)

References

[1]	周平,陈宗瑜. 云南高原紫外辐射强度变化时空特征分析[J]. 自然资源学报,2008,23(3):488-493.
[2]	pandel R,poljak B,Godic A,et al. Skin photoaging and the role of antioxidants in its prevention[J]. ISRN Dermatol,2013,68(5):1-11.
[3]	刘媛, 李福民, 廖金凤, 段西凌, 皮肤光老化机制研究进展[J], 临床皮肤科杂志, 2016, 45（6）: 479-481
[4]	poon F,Kang S,Chien A L. Mechanisms and treatments of pho- toaging[J]. Photodermatology,Photodermatol Photoimmunol Pho-tomed,2015,31(2):65-74. doi: 10.1111/phpp.12145
[5]	刘玮, 皮肤屏障功能解析[J], 中国皮肤性病学杂志, 2008（12）: 758-761
[6]	Mao Y,Ma J,Xia Y,et al. The overexpression of epidermal growth factor(EGF) in HaCaT cells promotes the proliferation,migration,invasion and transdifferentiation to epidermal stem cell immunophenotyping of adipose-derived stem cells (ADSCs)[J]. Int J Stem Cells,2020,3(1):93-103.
[7]	廖勇, 赵紫荆, 再生医学在医疗美容领域的研究进展[J], 实用皮肤病学杂志, 2021, 14（1）: 39-43
[8]	杨蓉娅, 夏志宽等, 电子注射（水光疗法）专家共识[J], 实用皮肤病学杂志, 2018, 11（2）: 65-67
[9]	何黎, 郑捷, 马慧群, 中国敏感性皮肤诊治专家共识[J], 中国皮肤性病学志, 2017, 31（1）: 1-4
[10]	Raj N,Voegeli R,Rawlings AV,et al. A fundamental investigation into aspects of the physiology and biochemistry of the stratum corneum in subjects with sensitive skin[J]. Int J Cosmet Sci,2017,39(1):2-10. doi: 10.1111/ics.12334

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