Volume 43 Issue 8
Jul.  2022
Turn off MathJax
Article Contents
Abstract
References
Relative Articles
Article Navigation >  Journal of Kunming Medical University  > 2022  >  43(8): 66-71
Rui CUN, Meiling CHEN. Efficacy and Clinical Application of Flunarizine Combined with Ginkgo damo in Treatment of Senile Vertigo[J]. Journal of Kunming Medical University, 2022, 43(7): 116-120. doi: 10.12259/j.issn.2095-610X.S20220703
Citation: Rong ZHANG, Xingju SONG, Lin Duan, Qian LI, Xu CHEN. Effect of Butylphthalide on NIHSS and Hemorheology in Patients with Acute Cerebral Infarction[J]. Journal of Kunming Medical University, 2022, 43(8): 66-71. doi: 10.12259/j.issn.2095-610X.S20220810
shu

Effect of Butylphthalide on NIHSS and Hemorheology in Patients with Acute Cerebral Infarction

doi: 10.12259/j.issn.2095-610X.S20220810
  • 1.

    Dept. of Neurology

  • 2.

    Dept .of Neurosurgery，Kunming Second People’s Hospital， Kunming Yunnan 650041，China

  • Received Date: 2022-03-09
  • Publish Date: 2022-08-25
    Abstract
  •   Objective   To investigate the influence of butylphthalide on National Institute of Health stroke Scale （NIHSS） and hemorheology in patients with acute cerebral infarction.   Methods   A total of 66 patients with acute cerebral infarction admitted to the Department of Neurology of Kunming Second People’s Hospital from March 2020 to April 2021 were selected and divided into study group and control group by numerical random table method. The control group received routine treatment, and the research group was treated with butylphthalide on the basis of routine treatment as in the control group. Hemorheology, efficacy of the two groups before and after treatment, neurological deficit score and adverse reactions of daily living ability were detected and compared.   Results   After treatment, the total effective rate of the study group was higher than that of the control group, and the difference was statistically significant （P < 0.05）. After treatment, the NHISS score of the study group was lower than that of the control group, and the Barthel index was higher than that of the control group, with statistical significance （ P < 0.05）. After treatment, the hemorheology indexes （whole blood specific viscosity, plasma specific viscosity, hematocrit and platelet aggregation rate）in the study group were lower than those in the control group, and the differences were statistically significant （ P < 0.05）. There was no significant difference in the adverse reaction rate between the study group and the control group （ P > 0.05）.   Conclusion   The use of butylphthalide for the treatment of acute cerebral infarction patients is effective, with improvement in patients’ neurological functions and hemorheology indicators. It is safe and worthy of application and promotion.
    • FullText(HTML)
    • References(38)
  • [1]
    杨娟,赵晓晖,李锦师,等. 丁苯酞注射液治疗不同严重程度的大脑中动脉脑梗死患者的疗效[J]. 昆明医科大学学报,2019,40(4):101-106. doi: 10.3969/j.issn.1003-4706.2019.04.021
    [2]
    王亚亚,王俐婷,张兆辉. 急性脑梗死患者血小板、凝血-纤溶血清标志物水平变化及意义[J]. 卒中与神经疾病,2019,26(6):754-758.
    [3]
    孔令胜,刘丽艳,赵平,等. 丁苯酞对急性脑梗死重组组织型纤溶酶原激活物静脉溶栓后出血性转化的影响[J]. 中国新药与临床杂志,2020,39(4):225-230.
    [4]
    岳西华. 丁苯酞注射液联合依达拉奉对急性脑梗死患者 临床疗效神经及认知功能的影响[J]. 中国药物与临床,2020,20(21):3655-3657.
    [5]
    钱文忠,张富山,杨小旺,等. 血浆D-二聚体与急性脑梗死的相关性研究[J]. 现代临床医学,2017,43(2):127-128. doi: 10.11851/j.issn.1673-1557.2017.02.016
    [6]
    张应魏,贝宁,张润泽,等. 丁苯酞联合马来酸桂哌齐特对急性脑梗死患者脑血流及神经功能相关指标水平的影响[J]. 疑难病杂志,2021,20(3):217-221. doi: 10.3969/j.issn.1671-6450.2021.03.001
    [7]
    胡勇,徐文锐,李俊. 丁苯酞在急性脑梗死患者中的应用效果及对患者神经功能影响的观察[J]. 贵州医药,2018,42(6):707-709.
    [8]
    康琳,李颖,王希,等. 丁苯酞联合综合干预对脑梗死恢复 期患者治疗效果分析[J]. 长春中医药大学学报,2022,38(4):439-442.
    [9]
    查莹莹,王丽,盛飞,等. 丁苯酞联合依达拉奉治疗急性脑梗死的Meta-分析[J]. 药物评价研究,2018,41(02):322-327.
    [10]
    李法良,陈龙,李静宇. 美国国立卫生研究院卒中量表评分和格拉斯哥昏迷评分对急性脑梗死患者溶栓治疗后出血的预测价值[J]. 中华老年医学杂志,2022,41(2):158-161. doi: 10.3760/cma.j.issn.0254-9026.2022.02.007
    [11]
    张颖,王殷,宋征宇,等. 丁苯酞联合血塞通注射液对急性脑梗死早期患者氧化应激及脑血流动力学的影响[J]. 疑难病杂志,2022,21(3):247-251.
    [12]
    刘文莹. 丁苯肽联合依达拉奉治疗急性脑梗死的疗效观察[J]. 中国冶金工业医学杂志,2021,38(5):566-567.
    [13]
    赵晓晶,李群喜,刘英,等. 美国国立卫生院脑卒中量表评分与脑出血患者预后的相关性探讨[J]. 中国临床医生杂志,2019,47(6):712-714. doi: 10.3969/j.issn.2095-8552.2019.06.028
    [14]
    张孟涛,崔晓萍. 急性脑梗死采用丁苯酞治疗后NIHSS、Barthel指数评分和脑血管储备能力的临床研究[J]. 医药论坛杂志,2019,40(12):111-113.
    [15]
    Huang Y,Pan L,Wu T. Improvement of cerebral ischemia-reperfusion injury by L-3-n-butylphthalide through promoting angiogenesis[J]. Experimental Brain Research,2021,239(4):1-10.
    [16]
    谢昊霖,王莉梅,韩铭,等. 丁苯酞注射液对急性缺血性脑梗死患者神经功能影响的Meta分析[J]. 中国新药与临床杂志,2016,35(7):492-498.
    [17]
    张立攀,朱云亮. 丁苯酞软胶囊联合脑蛋白水解物对急性脑梗死患者NIHSS评分及Keap1-Nrf2/ARE信号传导通路的影响[J]. 河北医学,2020,26(9):1454-1460. doi: 10.3969/j.issn.1006-6233.2020.09.012
    [18]
    李敏,黎玉环,熊光润,等. sss急性脑梗死患者血清组织蛋白酶S和血小板反应蛋白-1的表达及意义[J]. 昆明医科大学学报,2019,40(9):101-105.
    [19]
    孙维,菅志飞,张希洲. 丁苯酞联合血栓通治疗急性脑梗 死临床研究[J]. 中国药业,2022,31(2):97-99.
    [20]
    杨君君,陈颖,李伟,等. 丁苯酞联合依诺肝素钠对急性脑梗死纤溶系统和血液流变学的影响[J]. 心脑血管病防治,2020,20(2):207-210. doi: 10.3969/j.issn.1009-816x.2020.02.024
    [21]
    唐艳艳. 丁苯酞与依达拉奉联合用药方案治疗急性脑梗死的临床有效性和安全性评估[J]. 中国实用医药,2019,14(36):97-99.
    [22]
    李萍,胡文霞,翟宏江. 急性脑梗死患者发病后不同时间窗内接受静脉溶栓治疗的疗效比较[J]. 神经损伤与功能重建,2020,15(2):114-115.
    [23]
    徐鹏,侯双兴. 丁苯酞注射液联合针刺对急性脑梗死患者临床疗效观察[J]. 武警医学,2021,32(12):1043-1047.
    [24]
    Jiang X,Gu Q,Jiang Z,et al. Effect of family-centered nursing based on timing it right framework in patients with acute cerebral infarction[J]. American Journal of Translational Research,2021,13(4):3147-3155.
    [25]
    马蓉,徐弘扬,杨锡彤,等. 依达拉奉治疗急性脑梗死的临床疗效观察[J]. 山西医药杂志,2019,48(8):911-913.
    [26]
    尤晓涵,杨淼,明霞光,等. 盐酸川芎嗪注射液联合丁苯酞软胶囊治疗急性脑梗死疗效及对患者血液流变学影响[J]. 陕西中医,2020,41(6):743-745,757. doi: 10.3969/j.issn.1000-7369.2020.06.012
    [27]
    刘明月,胡建荣,姜晋灵,等. 丁苯酞对急性脑梗死患者神经功能及脑血管储备功能的影响[J]. 实用中西医结合临床,2021,21(7):94-96.
    [28]
    王琴,孔伟丽,吕康,等. 甘露醇注射液联合丁苯酞注射液对急性脑梗死患者治疗效果、氧化应激反应的影响[J]. 解放军医药杂志,2021,33(7):96-99,104. doi: 10.3969/j.issn.2095-140X.2021.07.022
    [29]
    Huang P,He X Y,Xu M. Effect of argatroban injection on clinical efficacy in patients with acute cerebral infarction:Preliminary findings[J]. European Neurology,2021,84(1):1-5. doi: 10.1159/000514265
    [30]
    吕虎,范从华,王晓伟. 丁苯酞联合阿替普酶静脉溶栓治疗对急性脑梗死患者神经功能和日常生活能力的影响[J]. 贵州医科大学学报,2020,45(12):1484-1488.
    [31]
    韩丽丽,项蓉,刘万根,等. Solitaire AB支架取栓术联合替罗非班和丁苯酞对急性脑梗死患者神经功能和炎性因子的影响[J]. 中国临床研究,2020,33(4):488-492.
    [32]
    杨东娜,张涤,于佳佳. 丁苯酞注射液联合依达拉奉对老年急性脑梗死患者细胞因子、血管内皮功能和氧化应激的影响[J]. 中国老年学杂志,2021,41(3):477-480.
    [33]
    Chen Z,Chen X,Fei S,et al. Effect of butylphthalide on cerebral infarction rats and its mechanism based on AMPK/eNOS/NF-κB(p65) signal pathway[J]. Latin American Journal of Pharmacy,2020,39(4):739-746.
    [34]
    甘馨,刘德浪,燕垚旬. 祛风导痰汤联合丁苯酞对急性脑梗死患者溶栓后神经功能恢复及NLR、PLR、血清NSE、S100蛋白的影响[J]. 中国中医急症,2021,30(8):1370-1373,1377. doi: 10.3969/j.issn.1004-745X.2021.08.013
    [35]
    Zeng J,Wang F,Feng H,et al. Influencing factors of recanalization after intravenous thrombolysis with urokinase in acute cerebral infarction patients[J]. European Neurology,2020,83(2):1-5.
    [36]
    郝锋利,徐巧绒,赵志茹. 丁苯酞联合依达拉奉治疗急性脑梗死的效果及对患者神经功能的影响[J]. 临床医学研究与实践,2019,4(22):27-29.
    [37]
    杨柳,黄军. 丁苯酞注射液联合依达拉奉治疗急性脑梗死的价值[J]. 中外医学研究,2022,20(12):18-21.
    [38]
    高文勇,艾艳萍,李姣,等. 丁苯酞联合巴曲酶治疗进展性急性脑梗死患者效果及作用机制[J]. 河北医药,2022,44(3):416-419.
    • Relative Articles(20)

  • Relative Articles

    [1] Kun WANG, Jun PU, Dongbo LI, Tao YANG. Efficacy of Microvascular Decompression for Moderate to Severe Hemifacial Spasm and the Influencing Factors of Delayed Resolution. Journal of Kunming Medical University, 2024, 45(10): 50-54.  doi: 10.12259/j.issn.2095-610X.S20241008
    [2] Wenxiu XU, Xiaofeng MO, Xiangmin YANG, Silu YANG, Fan WU, Te LI. Application of Logistic Regression and Decision Tree Model in Prediction of Adverse Reactions of Iodinated Contrast Medium. Journal of Kunming Medical University, 2024, 45(9): 70-75.  doi: 10.12259/j.issn.2095-610X.S20240911
    [3] Zhen XU, Yu LING, Sixiang LIU, Yu SONG, Yang PENG, Jingjing SUN. Adverse Reactions of Vaccine Vaccination in Children with Special Health Conditions in Kunming and Countermeasures. Journal of Kunming Medical University, 2024, 45(3): 141-145.  doi: 10.12259/j.issn.2095-610X.S20240321
    [4] Li DONG, Rongping NING, Qiongyi XIAO. Value of Multimodal Ultrasonography Combined with Clinical Indicators in Predicting the Progression of Ischemic Stroke. Journal of Kunming Medical University, 2024, 45(3): 166-173.  doi: 10.12259/j.issn.2095-610X.S20240325
    [5] Xiaopei LV, Shuai YUAN. The Effect of Butylphthalide on Cognitive Dysfunction after the Stroke Caused by Cerebral Small Vessel Disease and Its Effect on Cerebral Blood Perfusion. Journal of Kunming Medical University, 2023, 44(9): 143-147.  doi: 10.12259/j.issn.2095-610X.S20230922
    [6] Linling ZHU, Chenggang WANG, Hongliang YANG, Xiangling WEN. Observation of the Curative Effect of Enlarged and Opened Middle Turbinate Combined with Nerve Branch Block in Patients with Refractory Sinusitis. Journal of Kunming Medical University, 2022, 43(9): 96-100.  doi: 10.12259/j.issn.2095-610X.S20220919
    [7] Na LI, Jie CHEN, Ji LUO, Yong-gang CHEN, Jiang-li PENG, Ming-li YU, Sheng-hao LI. Retrospective Analysis of 376 Cases of Adverse Reactions to Antituberculosis Drug. Journal of Kunming Medical University, 2021, 42(4): 117-121.  doi: 10.12259/j.issn.2095-610X.S20210422
    [8] Zhao Xi Juan , Yang Ming Ying , He Yin , Qian Yang Feng , Tao Shi Qi , Zhang Jiang , Su Yan . . Journal of Kunming Medical University, 2020, 41(03): 174-178.
    [9] Guo An Li , Fu Chang Bi , Yang Xiao Qing , Zhang Shi Mei , Shi Zheng Juan . . Journal of Kunming Medical University, 2019, 40(12): 97-102.
    [10] Yang Juan , Zhao Xiao Hui , Li Jin Shi , Liu Hui Qin , Wang Ling Ling , Ren Hai Bing , Wang Si Si , Yan Jing , Sui Hai Jing . . Journal of Kunming Medical University, 2019, 40(04): 101-106.
    [11] Li Min , Li Yu Huan , Xiong Guang Run , Zheng Yong Qiang . . Journal of Kunming Medical University, 2019, 40(09): 101-105.
    [12] Xie Mu Xi Kai Mai Er ·Ao Bu Li Ka Si Mu , Tu Er Xun Na Yi ·Ai Hai Ti , Yang He Yin . . Journal of Kunming Medical University, 2019, 40(09): 23-28.
    [13] Tang Jia Hua . Influence of Autologuous Blood Transfusion on Hemorheology and Fracture Healing in Patients Undergoing Spinal Operation. Journal of Kunming Medical University,
    [14] Li Fei . Effect of Celebrex on the Hemorheology and Levels of Inflammatory Factors in Patients with Delayed Fracture Healing. Journal of Kunming Medical University,
    [15] He Feng Die . The Changes of Serum CRP， IL-2， MCP-1 and Hemorheology of Patients with Pelvic Inflammatory Disease. Journal of Kunming Medical University,
    [16] Gui Qi . . Journal of Kunming Medical University,
    [17] Zhang Li Juan . . Journal of Kunming Medical University,
    [18] Li Fu Ning . . Journal of Kunming Medical University,
    [19] . The Clinical Analysis of 60 Cases of Adverse Reactions caused by Blood Transfusion. Journal of Kunming Medical University,
    [20] . . Journal of Kunming Medical University,
    • Supplements(0)
    • Cited By

  • Cited by

    Periodical cited type(5)

    1. 陈安莉. 氟桂利嗪结合银杏达莫方案用于老年眩晕症患者的效果观察. 婚育与健康. 2025(04): 97-99 .
    2. 迟凯扬，赵洪运. 镇肝熄风汤联合氟桂利嗪对肝阳上亢型眩晕患者临床疗效及血流动力学指标的影响. 临床医学工程. 2024(11): 1347-1348 .
    3. 金赢政，井睿智，李金江. 天麻钩藤饮联合针灸治疗后循环缺血性眩晕临床研究. 新中医. 2023(22): 53-58 .
    4. 任淑珍，陈友芹，刘艳丽. 耳后注射倍他司汀联合氟桂利嗪治疗外周性眩晕的临床效果及对血流速度的影响. 实用中西医结合临床. 2023(20): 102-105 .
    5. 王凌燕，曹国军，龚甜，周诗晶. 银杏达莫注射液联合前列地尔治疗椎-基底动脉供血不足眩晕症患者的疗效及对血流动力学的影响. 湖南师范大学学报(医学版). 2023(06): 92-96 .

    Other cited types(0)

  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-0400.250.50.7511.25
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 38.7 %FULLTEXT: 38.7 %META: 60.8 %META: 60.8 %PDF: 0.5 %PDF: 0.5 %FULLTEXTMETAPDF
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 4.3 %其他: 4.3 %其他: 0.0 %其他: 0.0 %China: 3.8 %China: 3.8 %Falkenstein: 0.1 %Falkenstein: 0.1 %Rochester: 0.1 %Rochester: 0.1 %San Lorenzo: 0.0 %San Lorenzo: 0.0 %上海: 8.8 %上海: 8.8 %东京: 0.2 %东京: 0.2 %东莞: 0.2 %东莞: 0.2 %丽水: 0.1 %丽水: 0.1 %乌鲁木齐: 0.0 %乌鲁木齐: 0.0 %保定: 0.0 %保定: 0.0 %信阳: 0.0 %信阳: 0.0 %六安: 0.1 %六安: 0.1 %内华达: 0.0 %内华达: 0.0 %内华达州: 0.0 %内华达州: 0.0 %北京: 20.0 %北京: 20.0 %十堰: 0.3 %十堰: 0.3 %南京: 0.1 %南京: 0.1 %南宁: 0.2 %南宁: 0.2 %南昌: 0.0 %南昌: 0.0 %南通: 0.1 %南通: 0.1 %南阳: 0.0 %南阳: 0.0 %博阿努瓦: 0.0 %博阿努瓦: 0.0 %卡拉奇: 0.1 %卡拉奇: 0.1 %台州: 0.2 %台州: 0.2 %哈尔滨: 0.1 %哈尔滨: 0.1 %哥伦布: 0.0 %哥伦布: 0.0 %嘉兴: 0.1 %嘉兴: 0.1 %大连: 0.0 %大连: 0.0 %天津: 0.7 %天津: 0.7 %安那罕: 0.0 %安那罕: 0.0 %宣城: 0.2 %宣城: 0.2 %常州: 0.1 %常州: 0.1 %平顶山: 0.0 %平顶山: 0.0 %广州: 0.1 %广州: 0.1 %张家口: 0.2 %张家口: 0.2 %成都: 0.0 %成都: 0.0 %扬州: 0.4 %扬州: 0.4 %无锡: 0.1 %无锡: 0.1 %昆明: 0.3 %昆明: 0.3 %杭州: 0.4 %杭州: 0.4 %格兰特县: 0.0 %格兰特县: 0.0 %武汉: 0.0 %武汉: 0.0 %沈阳: 0.1 %沈阳: 0.1 %沧州: 0.0 %沧州: 0.0 %洛杉矶: 0.0 %洛杉矶: 0.0 %洛阳: 0.1 %洛阳: 0.1 %淄博: 0.0 %淄博: 0.0 %温州: 0.4 %温州: 0.4 %湖州: 0.3 %湖州: 0.3 %滨州: 0.0 %滨州: 0.0 %漯河: 1.6 %漯河: 1.6 %石家庄: 0.3 %石家庄: 0.3 %神农架: 0.1 %神农架: 0.1 %芒廷维尤: 5.6 %芒廷维尤: 5.6 %芝加哥: 0.1 %芝加哥: 0.1 %苏州: 0.0 %苏州: 0.0 %茂名: 0.0 %茂名: 0.0 %衡水: 0.1 %衡水: 0.1 %衢州: 0.3 %衢州: 0.3 %襄阳: 0.0 %襄阳: 0.0 %西宁: 1.5 %西宁: 1.5 %西雅图: 0.0 %西雅图: 0.0 %诺沃克: 0.1 %诺沃克: 0.1 %赤峰: 0.0 %赤峰: 0.0 %运城: 0.1 %运城: 0.1 %邯郸: 0.2 %邯郸: 0.2 %郑州: 0.1 %郑州: 0.1 %重庆: 0.0 %重庆: 0.0 %金华: 0.1 %金华: 0.1 %长沙: 0.8 %长沙: 0.8 %青岛: 0.5 %青岛: 0.5 %马赛: 0.0 %马赛: 0.0 %驻马店: 45.5 %驻马店: 45.5 %其他其他ChinaFalkensteinRochesterSan Lorenzo上海东京东莞丽水乌鲁木齐保定信阳六安内华达内华达州北京十堰南京南宁南昌南通南阳博阿努瓦卡拉奇台州哈尔滨哥伦布嘉兴大连天津安那罕宣城常州平顶山广州张家口成都扬州无锡昆明杭州格兰特县武汉沈阳沧州洛杉矶洛阳淄博温州湖州滨州漯河石家庄神农架芒廷维尤芝加哥苏州茂名衡水衢州襄阳西宁西雅图诺沃克赤峰运城邯郸郑州重庆金华长沙青岛马赛驻马店

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (4053) PDF downloads(28) Cited by(5)
    Proportional views
    Related

    Copyright © 《昆明医科大学学报》编辑部  滇ICP备00000000号-0

    Publishing: 昆明医科大学学报编辑部

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return