Effect of Butylphthalide on NIHSS and Hemorheology in Patients with Acute Cerebral Infarction

Rong ZHANG; Xingju SONG; Lin Duan; Qian LI; Xu CHEN

doi:10.12259/j.issn.2095-610X.S20220810

Volume 43 Issue 8

Jul. 2022

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Rong ZHANG, Xingju SONG, Lin Duan, Qian LI, Xu CHEN. Effect of Butylphthalide on NIHSS and Hemorheology in Patients with Acute Cerebral Infarction[J]. Journal of Kunming Medical University, 2022, 43(8): 66-71. doi: 10.12259/j.issn.2095-610X.S20220810

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Rong ZHANG, Xingju SONG, Lin Duan, Qian LI, Xu CHEN. Effect of Butylphthalide on NIHSS and Hemorheology in Patients with Acute Cerebral Infarction[J]. Journal of Kunming Medical University, 2022, 43(8): 66-71. doi: 10.12259/j.issn.2095-610X.S20220810

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Effect of Butylphthalide on NIHSS and Hemorheology in Patients with Acute Cerebral Infarction

doi: 10.12259/j.issn.2095-610X.S20220810

1.
Dept. of Neurology
2.
Dept .of Neurosurgery，Kunming Second People’s Hospital， Kunming Yunnan 650041，China

Received Date: 2022-03-09
Publish Date: 2022-08-25

Abstract

Abstract

Objective To investigate the influence of butylphthalide on National Institute of Health stroke Scale （NIHSS） and hemorheology in patients with acute cerebral infarction. Methods A total of 66 patients with acute cerebral infarction admitted to the Department of Neurology of Kunming Second People’s Hospital from March 2020 to April 2021 were selected and divided into study group and control group by numerical random table method. The control group received routine treatment, and the research group was treated with butylphthalide on the basis of routine treatment as in the control group. Hemorheology, efficacy of the two groups before and after treatment, neurological deficit score and adverse reactions of daily living ability were detected and compared. Results After treatment, the total effective rate of the study group was higher than that of the control group, and the difference was statistically significant （P < 0.05）. After treatment, the NHISS score of the study group was lower than that of the control group, and the Barthel index was higher than that of the control group, with statistical significance （ P < 0.05）. After treatment, the hemorheology indexes （whole blood specific viscosity, plasma specific viscosity, hematocrit and platelet aggregation rate）in the study group were lower than those in the control group, and the differences were statistically significant （ P < 0.05）. There was no significant difference in the adverse reaction rate between the study group and the control group （ P > 0.05）. Conclusion The use of butylphthalide for the treatment of acute cerebral infarction patients is effective, with improvement in patients’ neurological functions and hemorheology indicators. It is safe and worthy of application and promotion.
- Acute cerebral infarction,
- Butyl phthalide,
- Neurological impairment,
- Hemorheology,
- Clinical efficacy,
- Adverse reactions

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References

[1]	杨娟,赵晓晖,李锦师,等. 丁苯酞注射液治疗不同严重程度的大脑中动脉脑梗死患者的疗效[J]. 昆明医科大学学报,2019,40(4):101-106. doi: 10.3969/j.issn.1003-4706.2019.04.021
[2]	王亚亚,王俐婷,张兆辉. 急性脑梗死患者血小板、凝血-纤溶血清标志物水平变化及意义[J]. 卒中与神经疾病,2019,26(6):754-758.
[3]	孔令胜,刘丽艳,赵平,等. 丁苯酞对急性脑梗死重组组织型纤溶酶原激活物静脉溶栓后出血性转化的影响[J]. 中国新药与临床杂志,2020,39(4):225-230.
[4]	岳西华. 丁苯酞注射液联合依达拉奉对急性脑梗死患者临床疗效神经及认知功能的影响[J]. 中国药物与临床,2020,20(21):3655-3657.
[5]	钱文忠,张富山,杨小旺,等. 血浆D-二聚体与急性脑梗死的相关性研究[J]. 现代临床医学,2017,43(2):127-128. doi: 10.11851/j.issn.1673-1557.2017.02.016
[6]	张应魏,贝宁,张润泽,等. 丁苯酞联合马来酸桂哌齐特对急性脑梗死患者脑血流及神经功能相关指标水平的影响[J]. 疑难病杂志,2021,20(3):217-221. doi: 10.3969/j.issn.1671-6450.2021.03.001
[7]	胡勇,徐文锐,李俊. 丁苯酞在急性脑梗死患者中的应用效果及对患者神经功能影响的观察[J]. 贵州医药,2018,42(6):707-709.
[8]	康琳,李颖,王希,等. 丁苯酞联合综合干预对脑梗死恢复期患者治疗效果分析[J]. 长春中医药大学学报,2022,38(4):439-442.
[9]	查莹莹,王丽,盛飞,等. 丁苯酞联合依达拉奉治疗急性脑梗死的Meta-分析[J]. 药物评价研究,2018,41(02):322-327.
[10]	李法良,陈龙,李静宇. 美国国立卫生研究院卒中量表评分和格拉斯哥昏迷评分对急性脑梗死患者溶栓治疗后出血的预测价值[J]. 中华老年医学杂志,2022,41(2):158-161. doi: 10.3760/cma.j.issn.0254-9026.2022.02.007
[11]	张颖,王殷,宋征宇,等. 丁苯酞联合血塞通注射液对急性脑梗死早期患者氧化应激及脑血流动力学的影响[J]. 疑难病杂志,2022,21(3):247-251.
[12]	刘文莹. 丁苯肽联合依达拉奉治疗急性脑梗死的疗效观察[J]. 中国冶金工业医学杂志,2021,38(5):566-567.
[13]	赵晓晶,李群喜,刘英,等. 美国国立卫生院脑卒中量表评分与脑出血患者预后的相关性探讨[J]. 中国临床医生杂志,2019,47(6):712-714. doi: 10.3969/j.issn.2095-8552.2019.06.028
[14]	张孟涛,崔晓萍. 急性脑梗死采用丁苯酞治疗后NIHSS、Barthel指数评分和脑血管储备能力的临床研究[J]. 医药论坛杂志,2019,40(12):111-113.
[15]	Huang Y,Pan L,Wu T. Improvement of cerebral ischemia-reperfusion injury by L-3-n-butylphthalide through promoting angiogenesis[J]. Experimental Brain Research,2021,239(4):1-10.
[16]	谢昊霖,王莉梅,韩铭,等. 丁苯酞注射液对急性缺血性脑梗死患者神经功能影响的Meta分析[J]. 中国新药与临床杂志,2016,35(7):492-498.
[17]	张立攀,朱云亮. 丁苯酞软胶囊联合脑蛋白水解物对急性脑梗死患者NIHSS评分及Keap1-Nrf2/ARE信号传导通路的影响[J]. 河北医学,2020,26(9):1454-1460. doi: 10.3969/j.issn.1006-6233.2020.09.012
[18]	李敏,黎玉环,熊光润,等. sss急性脑梗死患者血清组织蛋白酶S和血小板反应蛋白-1的表达及意义[J]. 昆明医科大学学报,2019,40(9):101-105.
[19]	孙维,菅志飞,张希洲. 丁苯酞联合血栓通治疗急性脑梗死临床研究[J]. 中国药业,2022,31(2):97-99.
[20]	杨君君,陈颖,李伟,等. 丁苯酞联合依诺肝素钠对急性脑梗死纤溶系统和血液流变学的影响[J]. 心脑血管病防治,2020,20(2):207-210. doi: 10.3969/j.issn.1009-816x.2020.02.024
[21]	唐艳艳. 丁苯酞与依达拉奉联合用药方案治疗急性脑梗死的临床有效性和安全性评估[J]. 中国实用医药,2019,14(36):97-99.
[22]	李萍,胡文霞,翟宏江. 急性脑梗死患者发病后不同时间窗内接受静脉溶栓治疗的疗效比较[J]. 神经损伤与功能重建,2020,15(2):114-115.
[23]	徐鹏,侯双兴. 丁苯酞注射液联合针刺对急性脑梗死患者临床疗效观察[J]. 武警医学,2021,32(12):1043-1047.
[24]	Jiang X,Gu Q,Jiang Z,et al. Effect of family-centered nursing based on timing it right framework in patients with acute cerebral infarction[J]. American Journal of Translational Research,2021,13(4):3147-3155.
[25]	马蓉,徐弘扬,杨锡彤,等. 依达拉奉治疗急性脑梗死的临床疗效观察[J]. 山西医药杂志,2019,48(8):911-913.
[26]	尤晓涵,杨淼,明霞光,等. 盐酸川芎嗪注射液联合丁苯酞软胶囊治疗急性脑梗死疗效及对患者血液流变学影响[J]. 陕西中医,2020,41(6):743-745,757. doi: 10.3969/j.issn.1000-7369.2020.06.012
[27]	刘明月,胡建荣,姜晋灵,等. 丁苯酞对急性脑梗死患者神经功能及脑血管储备功能的影响[J]. 实用中西医结合临床,2021,21(7):94-96.
[28]	王琴,孔伟丽,吕康,等. 甘露醇注射液联合丁苯酞注射液对急性脑梗死患者治疗效果、氧化应激反应的影响[J]. 解放军医药杂志,2021,33(7):96-99,104. doi: 10.3969/j.issn.2095-140X.2021.07.022
[29]	Huang P,He X Y,Xu M. Effect of argatroban injection on clinical efficacy in patients with acute cerebral infarction:Preliminary findings[J]. European Neurology,2021,84(1):1-5. doi: 10.1159/000514265
[30]	吕虎,范从华,王晓伟. 丁苯酞联合阿替普酶静脉溶栓治疗对急性脑梗死患者神经功能和日常生活能力的影响[J]. 贵州医科大学学报,2020,45(12):1484-1488.
[31]	韩丽丽,项蓉,刘万根,等. Solitaire AB支架取栓术联合替罗非班和丁苯酞对急性脑梗死患者神经功能和炎性因子的影响[J]. 中国临床研究,2020,33(4):488-492.
[32]	杨东娜,张涤,于佳佳. 丁苯酞注射液联合依达拉奉对老年急性脑梗死患者细胞因子、血管内皮功能和氧化应激的影响[J]. 中国老年学杂志,2021,41(3):477-480.
[33]	Chen Z,Chen X,Fei S,et al. Effect of butylphthalide on cerebral infarction rats and its mechanism based on AMPK/eNOS/NF-κB(p65) signal pathway[J]. Latin American Journal of Pharmacy,2020,39(4):739-746.
[34]	甘馨,刘德浪,燕垚旬. 祛风导痰汤联合丁苯酞对急性脑梗死患者溶栓后神经功能恢复及NLR、PLR、血清NSE、S100蛋白的影响[J]. 中国中医急症,2021,30(8):1370-1373,1377. doi: 10.3969/j.issn.1004-745X.2021.08.013
[35]	Zeng J,Wang F,Feng H,et al. Influencing factors of recanalization after intravenous thrombolysis with urokinase in acute cerebral infarction patients[J]. European Neurology,2020,83(2):1-5.
[36]	郝锋利,徐巧绒,赵志茹. 丁苯酞联合依达拉奉治疗急性脑梗死的效果及对患者神经功能的影响[J]. 临床医学研究与实践,2019,4(22):27-29.
[37]	杨柳,黄军. 丁苯酞注射液联合依达拉奉治疗急性脑梗死的价值[J]. 中外医学研究,2022,20(12):18-21.
[38]	高文勇,艾艳萍,李姣,等. 丁苯酞联合巴曲酶治疗进展性急性脑梗死患者效果及作用机制[J]. 河北医药,2022,44(3):416-419.

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