Immunological Characteristics of Patients with Active and Nonactive Pulmonary Tuberculosis

Lingjun SHEN; Lin WANG; Zhiqiang MA; Xing LIU; Haiwen LI; Ge WANG; Wenming LI; Pengju LUO

doi:10.12259/j.issn.2095-610X.S20220821

Volume 43 Issue 8

Jul. 2022

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Lingjun SHEN, Lin WANG, Zhiqiang MA, Xing LIU, Haiwen LI, Ge WANG, Wenming LI, Pengju LUO. Immunological Characteristics of Patients with Active and Nonactive Pulmonary Tuberculosis[J]. Journal of Kunming Medical University, 2022, 43(8): 122-126. doi: 10.12259/j.issn.2095-610X.S20220821

Citation:

Lingjun SHEN, Lin WANG, Zhiqiang MA, Xing LIU, Haiwen LI, Ge WANG, Wenming LI, Pengju LUO. Immunological Characteristics of Patients with Active and Nonactive Pulmonary Tuberculosis[J]. Journal of Kunming Medical University, 2022, 43(8): 122-126. doi: 10.12259/j.issn.2095-610X.S20220821

Citation:

Lingjun SHEN, Lin WANG, Zhiqiang MA, Xing LIU, Haiwen LI, Ge WANG, Wenming LI, Pengju LUO. Immunological Characteristics of Patients with Active and Nonactive Pulmonary Tuberculosis[J]. Journal of Kunming Medical University, 2022, 43(8): 122-126. doi: 10.12259/j.issn.2095-610X.S20220821

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Immunological Characteristics of Patients with Active and Nonactive Pulmonary Tuberculosis

doi: 10.12259/j.issn.2095-610X.S20220821

Dept. of Integrated tuberculosis，The 3rd People’s Hospital of Kunming/The Clinical Medical Center for Infectious Diseases of Yunnan，Kunming Yunnan 650301，China

Received Date: 2022-03-28
Publish Date: 2022-08-25

Abstract

Abstract

Objective To investigate the characteristics and significance of immune function in patients with active and non-active pulmonary tuberculosis. Methods A total of 78 patients with active tuberculosis treated in Kunming Third People’s Hospital from January 2020 to January 2021 were enrolled as the control group, and 28 patients with non-active tuberculosis were enrolled as the observation group. The expression levels of antibodies and cytokines and immune cell production in the two groups were analyzed. Results Compared with the control group, the levels of IFN-γ and IL-6 in observation group were decreased, and the differences were statistically significant （P < 0.05）. There was no significant difference in the levels of IgG, IgA, IgM and other 10 cytokines including IL-1, IL-2, IL-4, IL-5, IL-8 （ P > 0.05）; CD3 ⁺T, CD4⁺T, CD8⁺T cells and CD4⁺/CD8⁺ increased, the absolute numbers of lymphocytes and NK cells decreased, and the differences were statistically significant （P < 0.05）, while the absolute numbers of B cells showed no significant difference （ P > 0.05）. Conclusion Cytokines IFN-γ, IL-6 and lymphocyte subsets can be used as reference indicators of immune function in patients with inactive pulmonary tuberculosis, and have certain guiding significance for active relapse of tuberculosis.
- Active tuberculosis,
- Non-active tuberculosis,
- Immune status

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References(27)

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